raf1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Raf-1 proto-oncogene, serine/threonine kinase|This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5894)
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Genes

83 genes co-occuring with the biological term raf1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADCY6 adenylate cyclase 6
ADD1 adducin 1 (alpha)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALOX15 arachidonate 15-lipoxygenase
ASCL1 achaete-scute family bHLH transcription factor 1
BAD BCL2-associated agonist of cell death
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BIRC7 baculoviral IAP repeat containing 7
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCC3 BRCA1/BRCA2-containing complex, subunit 3
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CD209 CD209 molecule
CLEC7A C-type lectin domain family 7, member A
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB2IP erbb2 interacting protein
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FOXM1 forkhead box M1
GRB10 growth factor receptor-bound protein 10
HRAS Harvey rat sarcoma viral oncogene homolog
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IL6 interleukin 6
KLF10 Kruppel-like factor 10
KRAS Kirsten rat sarcoma viral oncogene homolog
KSR1 kinase suppressor of ras 1
LAMC2 laminin, gamma 2
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
LCK LCK proto-oncogene, Src family tyrosine kinase
LSP1 lymphocyte-specific protein 1
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MIR195 microRNA 195
MIR7-1 microRNA 7-1
MIR7-2 microRNA 7-2
MIR7-3 microRNA 7-3
MKRN2 makorin ring finger protein 2
NEK10 NIMA-related kinase 10
NF2 neurofibromin 2 (merlin)
NOS1 nitric oxide synthase 1 (neuronal)
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PAQR3 progestin and adipoQ receptor family member III
PDCD6 programmed cell death 6
PDE8A phosphodiesterase 8A
PEBP1 phosphatidylethanolamine binding protein 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PPP5C protein phosphatase 5, catalytic subunit
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RMDN3 regulator of microtubule dynamics 3
SHOC2 soc-2 suppressor of clear homolog (C. elegans)
SOS1 son of sevenless homolog 1 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK3 serine/threonine kinase 3
SYK spleen tyrosine kinase
TNF tumor necrosis factor
VEGFA vascular endothelial growth factor A
WISP1 WNT1 inducible signaling pathway protein 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase