raloxifene-2738 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the raloxifene-2738 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM2 ADAM metallopeptidase domain 2
ADRA1A adrenoceptor alpha 1A
ALDOAP2 aldolase A, fructose-bisphosphate pseudogene 2
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALOX15B arachidonate 15-lipoxygenase, type B
C14ORF105 chromosome 14 open reading frame 105
C7ORF26 chromosome 7 open reading frame 26
C8A complement component 8, alpha polypeptide
CALD1 caldesmon 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP5 caspase 5, apoptosis-related cysteine peptidase
CD5 CD5 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CLDN3 claudin 3
CLEC10A C-type lectin domain family 10, member A
CNN1 calponin 1, basic, smooth muscle
COL19A1 collagen, type XIX, alpha 1
CRH corticotropin releasing hormone
CSHL1 chorionic somatomammotropin hormone-like 1
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein)
EBF2 early B-cell factor 2
FERMT1 fermitin family member 1
FGFR2 fibroblast growth factor receptor 2
FLJ11292
FRMPD1 FERM and PDZ domain containing 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GBP1 guanylate binding protein 1, interferon-inducible
GLRA2 glycine receptor, alpha 2
GNAS GNAS complex locus
GRM4 glutamate receptor, metabotropic 4
GSTA3 glutathione S-transferase alpha 3
HAMP hepcidin antimicrobial peptide
HEG1 heart development protein with EGF-like domains 1
HIST1H2BJ histone cluster 1, H2bj
HLA-DOA major histocompatibility complex, class II, DO alpha
HOXA6 homeobox A6
HOXD13 homeobox D13
HSPB6 heat shock protein, alpha-crystallin-related, B6
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
JPH3 junctophilin 3
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KIF1C kinesin family member 1C
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT81 keratin 81, type II
KSR1 kinase suppressor of ras 1
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LMF1 lipase maturation factor 1
MBNL2 muscleblind-like splicing regulator 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MRPS18C mitochondrial ribosomal protein S18C
MYLK myosin light chain kinase
NCOR2 nuclear receptor corepressor 2
NLGN1 neuroligin 1
NMUR1 neuromedin U receptor 1
NPPB natriuretic peptide B
NRG1 neuregulin 1
OSBP2 oxysterol binding protein 2
PADI4 peptidyl arginine deiminase, type IV
PBOV1 prostate and breast cancer overexpressed 1
PCDHGB6 protocadherin gamma subfamily B, 6
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POM121L9P POM121 transmembrane nucleoporin-like 9, pseudogene
PRDM12 PR domain containing 12
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RAPSN receptor-associated protein of the synapse
RBP3 retinol binding protein 3, interstitial
RBPMS RNA binding protein with multiple splicing
RGS4 regulator of G-protein signaling 4
RHO rhodopsin
RIMS2 regulating synaptic membrane exocytosis 2
RPLP2 ribosomal protein, large, P2
SCN2B sodium channel, voltage gated, type II beta subunit
SEZ6L seizure related 6 homolog (mouse)-like
SIM2 single-minded family bHLH transcription factor 2
SMR3A submaxillary gland androgen regulated protein 3A
SMR3B submaxillary gland androgen regulated protein 3B
SNCG synuclein, gamma (breast cancer-specific protein 1)
SPAG8 sperm associated antigen 8
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
SUGCT succinyl-CoA:glutarate-CoA transferase
SYT5 synaptotagmin V
THRA thyroid hormone receptor, alpha
TJP3 tight junction protein 3
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLX3 T-cell leukemia homeobox 3
TMEM212 transmembrane protein 212
TRIM2 tripartite motif containing 2
TRIO trio Rho guanine nucleotide exchange factor
ZNF415 zinc finger protein 415
ZNF44 zinc finger protein 44

decreased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADORA3 adenosine A3 receptor
AMDHD2 amidohydrolase domain containing 2
ANKRD55 ankyrin repeat domain 55
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARMCX4 armadillo repeat containing, X-linked 4
ASPN asporin
ATHL1 ATH1, acid trehalase-like 1 (yeast)
C11ORF21 chromosome 11 open reading frame 21
C16ORF45 chromosome 16 open reading frame 45
C17ORF53 chromosome 17 open reading frame 53
C8ORF44 chromosome 8 open reading frame 44
CCDC57 coiled-coil domain containing 57
CCDC71 coiled-coil domain containing 71
CD300C CD300c molecule
CD37 CD37 molecule
CDK20 cyclin-dependent kinase 20
CEP70 centrosomal protein 70kDa
CFP complement factor properdin
CHM choroideremia (Rab escort protein 1)
CLCN5 chloride channel, voltage-sensitive 5
CLEC2D C-type lectin domain family 2, member D
CNR2 cannabinoid receptor 2 (macrophage)
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
DCAF13 DDB1 and CUL4 associated factor 13
DHRS11 dehydrogenase/reductase (SDR family) member 11
DNM3 dynamin 3
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EFNA3 ephrin-A3
EFNA4 ephrin-A4
EMILIN2 elastin microfibril interfacer 2
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
F13A1 coagulation factor XIII, A1 polypeptide
FAM127B family with sequence similarity 127, member B
FAM131A family with sequence similarity 131, member A
FBXO22 F-box protein 22
FKBP9 FK506 binding protein 9, 63 kDa
FOXO4 forkhead box O4
FSTL3 follistatin-like 3 (secreted glycoprotein)
GCH1 GTP cyclohydrolase 1
GK3P glycerol kinase 3 pseudogene
GRPR gastrin-releasing peptide receptor
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HLA-DMA major histocompatibility complex, class II, DM alpha
INCENP inner centromere protein antigens 135/155kDa
INF2 inverted formin, FH2 and WH2 domain containing
LIG4 ligase IV, DNA, ATP-dependent
LIN7A lin-7 homolog A (C. elegans)
LIN7B lin-7 homolog B (C. elegans)
LZTS3 leucine zipper, putative tumor suppressor family member 3
MDM4 MDM4, p53 regulator
MEP1B meprin A, beta
MMP9 matrix metallopeptidase 9
MTL5 metallothionein-like 5, testis-specific (tesmin)
MXD3 MAX dimerization protein 3
NCALD neurocalcin delta
NFE2L3 nuclear factor, erythroid 2-like 3
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NMB neuromedin B
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PARP12 poly (ADP-ribose) polymerase family, member 12
PCBP4 poly(rC) binding protein 4
PCDHGB5 protocadherin gamma subfamily B, 5
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRR7 proline rich 7 (synaptic)
RIN1 Ras and Rab interactor 1
RNF122 ring finger protein 122
RRAGB Ras-related GTP binding B
SCN10A sodium channel, voltage gated, type X alpha subunit
SERINC5 serine incorporator 5
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC35F6 solute carrier family 35, member F6
SLPI secretory leukocyte peptidase inhibitor
SMAD5 SMAD family member 5
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SYNJ2BP synaptojanin 2 binding protein
TBL1Y transducin (beta)-like 1, Y-linked
TET3 tet methylcytosine dioxygenase 3
THBS3 thrombospondin 3
TMEM53 transmembrane protein 53
TPM3 tropomyosin 3
TRIM25 tripartite motif containing 25
TXLNG taxilin gamma
URGCP upregulator of cell proliferation
VN1R1 vomeronasal 1 receptor 1
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR62 WD repeat domain 62
YY2 YY2 transcription factor
ZFHX4 zinc finger homeobox 4
ZNF155 zinc finger protein 155
ZNF34 zinc finger protein 34
ZNF510 zinc finger protein 510
ZNF778 zinc finger protein 778
ZNHIT2 zinc finger, HIT-type containing 2