raloxifene-5759 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the raloxifene-5759 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
AAMDC adipogenesis associated, Mth938 domain containing
ACAN aggrecan
ADD2 adducin 2 (beta)
AGO4 argonaute RISC catalytic component 4
AKAP1 A kinase (PRKA) anchor protein 1
ANGPTL4 angiopoietin-like 4
AQP4 aquaporin 4
ARPIN actin-related protein 2/3 complex inhibitor
ARRB1 arrestin, beta 1
ATP9A ATPase, class II, type 9A
BCL3 B-cell CLL/lymphoma 3
BMP7 bone morphogenetic protein 7
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C17ORF59 chromosome 17 open reading frame 59
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CFAP69 cilia and flagella associated protein 69
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CIB2 calcium and integrin binding family member 2
CLTA clathrin, light chain A
CNTFR ciliary neurotrophic factor receptor
CPNE7 copine VII
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DAPK2 death-associated protein kinase 2
DRD2 dopamine receptor D2
EGR2 early growth response 2
EPB41L5 erythrocyte membrane protein band 4.1 like 5
F13A1 coagulation factor XIII, A1 polypeptide
FAM212B family with sequence similarity 212, member B
FGFR2 fibroblast growth factor receptor 2
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
HBS1L HBS1-like translational GTPase
HDC histidine decarboxylase
HPCAL4 hippocalcin like 4
IL2RG interleukin 2 receptor, gamma
INO80D INO80 complex subunit D
INSIG1 insulin induced gene 1
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
KLF6 Kruppel-like factor 6
KRT34 keratin 34, type I
KRT38 keratin 38, type I
LENEP lens epithelial protein
LIME1 Lck interacting transmembrane adaptor 1
LMO1 LIM domain only 1 (rhombotin 1)
MAP2K5 mitogen-activated protein kinase kinase 5
MCOLN3 mucolipin 3
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTMR3 myotubularin related protein 3
MTMR8 myotubularin related protein 8
N4BP1 NEDD4 binding protein 1
NCAN neurocan
NPPA natriuretic peptide A
ODAM odontogenic, ameloblast asssociated
PACS1 phosphofurin acidic cluster sorting protein 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE4D phosphodiesterase 4D, cAMP-specific
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRKG2 protein kinase, cGMP-dependent, type II
RAB6A RAB6A, member RAS oncogene family
RBMS2 RNA binding motif, single stranded interacting protein 2
RGS17 regulator of G-protein signaling 17
RNF43 ring finger protein 43
RNF6 ring finger protein (C3H2C3 type) 6
RPL10L ribosomal protein L10-like
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
RUNX1 runt-related transcription factor 1
SCNN1G sodium channel, non voltage gated 1 gamma subunit
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SIGLEC6 sialic acid binding Ig-like lectin 6
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SP1 Sp1 transcription factor
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
STAB1 stabilin 1
TCP11 t-complex 11, testis-specific
TEF thyrotrophic embryonic factor
TFEB transcription factor EB
TRPC4 transient receptor potential cation channel, subfamily C, member 4
TUBA8 tubulin, alpha 8
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
USP29 ubiquitin specific peptidase 29
VCX2 variable charge, X-linked 2
YIPF2 Yip1 domain family, member 2
ZBTB17 zinc finger and BTB domain containing 17
ZNF76 zinc finger protein 76
ZSCAN32 zinc finger and SCAN domain containing 32

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACKR3 atypical chemokine receptor 3
AFAP1 actin filament associated protein 1
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ANP32A-IT1 ANP32A intronic transcript 1
ANXA2P3 annexin A2 pseudogene 3
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARL14 ADP-ribosylation factor-like 14
C11ORF71 chromosome 11 open reading frame 71
C1R complement component 1, r subcomponent
C7ORF43 chromosome 7 open reading frame 43
CA8 carbonic anhydrase VIII
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCDC94 coiled-coil domain containing 94
CHM choroideremia (Rab escort protein 1)
CHMP6 charged multivesicular body protein 6
COBL cordon-bleu WH2 repeat protein
COCH cochlin
CREB5 cAMP responsive element binding protein 5
CXCL3 chemokine (C-X-C motif) ligand 3
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DENND2D DENN/MADD domain containing 2D
DEPTOR DEP domain containing MTOR-interacting protein
DNAL4 dynein, axonemal, light chain 4
DOK5 docking protein 5
EFNB1 ephrin-B1
EGF epidermal growth factor
EGFL7 EGF-like-domain, multiple 7
ELP6 elongator acetyltransferase complex subunit 6
ERCC4 excision repair cross-complementation group 4
ERN2 endoplasmic reticulum to nucleus signaling 2
FAIM Fas apoptotic inhibitory molecule
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGF13 fibroblast growth factor 13
FGL1 fibrinogen-like 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GRAMD1C GRAM domain containing 1C
HAS2 hyaluronan synthase 2
HIST1H2AI histone cluster 1, H2ai
HIST1H2BM histone cluster 1, H2bm
HOXC13 homeobox C13
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFNA14 interferon, alpha 14
IPO8 importin 8
IRAK4 interleukin-1 receptor-associated kinase 4
JMJD4 jumonji domain containing 4
KIAA1462 KIAA1462
KLK5 kallikrein-related peptidase 5
KRT31 keratin 31, type I
L2HGDH L-2-hydroxyglutarate dehydrogenase
LINS lines homolog (Drosophila)
LMNB1 lamin B1
LRRC6 leucine rich repeat containing 6
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MANEA mannosidase, endo-alpha
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MOXD1 monooxygenase, DBH-like 1
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MUC3A mucin 3A, cell surface associated
MX1 MX dynamin-like GTPase 1
MXD3 MAX dimerization protein 3
NDP Norrie disease (pseudoglioma)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NME5 NME/NM23 family member 5
NPFFR1 neuropeptide FF receptor 1
NRTN neurturin
OLFML2A olfactomedin-like 2A
P3H2 prolyl 3-hydroxylase 2
PCDHGB5 protocadherin gamma subfamily B, 5
PLCD1 phospholipase C, delta 1
PRAMEF11 PRAME family member 11
PTK7 protein tyrosine kinase 7 (inactive)
RAB3A RAB3A, member RAS oncogene family
RARS arginyl-tRNA synthetase
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
SCN10A sodium channel, voltage gated, type X alpha subunit
SDC3 syndecan 3
SETBP1 SET binding protein 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TMC5 transmembrane channel-like 5
TNNI3 troponin I type 3 (cardiac)
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TUBA3C tubulin, alpha 3c
WDR78 WD repeat domain 78
ZBTB22 zinc finger and BTB domain containing 22
ZBTB39 zinc finger and BTB domain containing 39
ZNF350 zinc finger protein 350
ZNF428 zinc finger protein 428
ZNF552 zinc finger protein 552
ZNF768 zinc finger protein 768