ranitidine-2088 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the ranitidine-2088 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADAM5 ADAM metallopeptidase domain 5 (pseudogene)
AHI1 Abelson helper integration site 1
AIRE autoimmune regulator
AK1 adenylate kinase 1
ANXA2P1 annexin A2 pseudogene 1
APLP2 amyloid beta (A4) precursor-like protein 2
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATP9A ATPase, class II, type 9A
C1QL1 complement component 1, q subcomponent-like 1
CALD1 caldesmon 1
CCDC64 coiled-coil domain containing 64
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHGA chromogranin A
CNOT4 CCR4-NOT transcription complex, subunit 4
CREB5 cAMP responsive element binding protein 5
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1
DHRS9 dehydrogenase/reductase (SDR family) member 9
DLX2 distal-less homeobox 2
DMTN dematin actin binding protein
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DOK4 docking protein 4
ERCC4 excision repair cross-complementation group 4
ESRRA estrogen-related receptor alpha
FABP3 fatty acid binding protein 3, muscle and heart
FLJ22184
FN1 fibronectin 1
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GMEB1 glucocorticoid modulatory element binding protein 1
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR85 G protein-coupled receptor 85
GSTA3 glutathione S-transferase alpha 3
HAL histidine ammonia-lyase
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HIC2 hypermethylated in cancer 2
HIST1H1E histone cluster 1, H1e
HIST1H4D histone cluster 1, H4d
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HOOK1 hook microtubule-tethering protein 1
KDM5C lysine (K)-specific demethylase 5C
LBX1 ladybird homeobox 1
LINC00341 long intergenic non-protein coding RNA 341
LOC729164 hCG1732469
LPPR4 lipid phosphate phosphatase-related protein type 4
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene
LYPD3 LY6/PLAUR domain containing 3
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MCL1 myeloid cell leukemia 1
MCM9 minichromosome maintenance complex component 9
MIIP migration and invasion inhibitory protein
MKL1 megakaryoblastic leukemia (translocation) 1
MRAS muscle RAS oncogene homolog
MTCP1 mature T-cell proliferation 1
NOP14-AS1 NOP14 antisense RNA 1
ORM1 orosomucoid 1
PACS1 phosphofurin acidic cluster sorting protein 1
PAX4 paired box 4
PIP prolactin-induced protein
PPP1R7 protein phosphatase 1, regulatory subunit 7
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
REST RE1-silencing transcription factor
RIBC2 RIB43A domain with coiled-coils 2
RNF126P1 ring finger protein 126 pseudogene 1
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
RUNX3 runt-related transcription factor 3
SBNO1 strawberry notch homolog 1 (Drosophila)
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SERGEF secretion regulating guanine nucleotide exchange factor
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SMG7 SMG7 nonsense mediated mRNA decay factor
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SPTBN2 spectrin, beta, non-erythrocytic 2
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
SUGP1 SURP and G patch domain containing 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TACC1 transforming, acidic coiled-coil containing protein 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFA transforming growth factor, alpha
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TLR2 toll-like receptor 2
TMEM231 transmembrane protein 231
TMEM63A transmembrane protein 63A
TRIM23 tripartite motif containing 23
TRIM25 tripartite motif containing 25
USF2 upstream transcription factor 2, c-fos interacting
USP12 ubiquitin specific peptidase 12
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae)
WDR1 WD repeat domain 1
WIPI2 WD repeat domain, phosphoinositide interacting 2
ZNF286A zinc finger protein 286A
ZNF480 zinc finger protein 480
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
C19ORF54 chromosome 19 open reading frame 54
CBR1 carbonyl reductase 1
CCDC68 coiled-coil domain containing 68
CDK5RAP2 CDK5 regulatory subunit associated protein 2
COBL cordon-bleu WH2 repeat protein
CPSF3L cleavage and polyadenylation specific factor 3-like
CXCL2 chemokine (C-X-C motif) ligand 2
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DOCK1 dedicator of cytokinesis 1
ERAP2 endoplasmic reticulum aminopeptidase 2
ERMP1 endoplasmic reticulum metallopeptidase 1
FAM179B family with sequence similarity 179, member B
FER fer (fps/fes related) tyrosine kinase
FOXC1 forkhead box C1
GMIP GEM interacting protein
GMPPA GDP-mannose pyrophosphorylase A
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPATCH3 G patch domain containing 3
HCG4 HLA complex group 4 (non-protein coding)
HEATR3 HEAT repeat containing 3
HOXB9 homeobox B9
HP1BP3 heterochromatin protein 1, binding protein 3
IP6K2 inositol hexakisphosphate kinase 2
IRF2 interferon regulatory factor 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KIAA0922 KIAA0922
LIG4 ligase IV, DNA, ATP-dependent
LMNB2 lamin B2
LOC730101 uncharacterized LOC730101
MAN2C1 mannosidase, alpha, class 2C, member 1
MED22 mediator complex subunit 22
METTL2B methyltransferase like 2B
MON1B MON1 secretory trafficking family member B
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NMB neuromedin B
NMRK1 nicotinamide riboside kinase 1
NOD1 nucleotide-binding oligomerization domain containing 1
NPM3 nucleophosmin/nucleoplasmin 3
NR2C2 nuclear receptor subfamily 2, group C, member 2
NTHL1 nth endonuclease III-like 1 (E. coli)
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3
NVL nuclear VCP-like
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OLFML2A olfactomedin-like 2A
OSMR oncostatin M receptor
PARPBP PARP1 binding protein
PCF11 PCF11 cleavage and polyadenylation factor subunit
PCSK7 proprotein convertase subtilisin/kexin type 7
PHKG2 phosphorylase kinase, gamma 2 (testis)
PIEZO1 piezo-type mechanosensitive ion channel component 1
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLA2G15 phospholipase A2, group XV
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCD1 phospholipase C, delta 1
PLEKHA6 pleckstrin homology domain containing, family A member 6
POLR1E polymerase (RNA) I polypeptide E, 53kDa
PTDSS2 phosphatidylserine synthase 2
PTGES2 prostaglandin E synthase 2
RNF123 ring finger protein 123
RPAP2 RNA polymerase II associated protein 2
RPP25 ribonuclease P/MRP 25kDa subunit
RUSC2 RUN and SH3 domain containing 2
SAMD9 sterile alpha motif domain containing 9
SCAMP4 secretory carrier membrane protein 4
SCAMP5 secretory carrier membrane protein 5
SERINC5 serine incorporator 5
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLC35E3 solute carrier family 35, member E3
STAG3 stromal antigen 3
STRN4 striatin, calmodulin binding protein 4
SYNPO synaptopodin
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TESK2 testis-specific kinase 2
THOC6 THO complex 6
TLN1 talin 1
TMEM183A transmembrane protein 183A
TMEM242 transmembrane protein 242
TPST2 tyrosylprotein sulfotransferase 2
TRAPPC2 trafficking protein particle complex 2
TRIP10 thyroid hormone receptor interactor 10
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TSPYL4 TSPY-like 4
TUBG2 tubulin, gamma 2
UBXN6 UBX domain protein 6
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF280D zinc finger protein 280D
ZNF551 zinc finger protein 551
ZNF767P zinc finger family member 767, pseudogene
ZNF8 zinc finger protein 8
ZW10 zw10 kinetochore protein