ranitidine-2251 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the ranitidine-2251 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AIM1L absent in melanoma 1-like
ALOX15B arachidonate 15-lipoxygenase, type B
ATN1 atrophin 1
BHMT2 betaine--homocysteine S-methyltransferase 2
BMP10 bone morphogenetic protein 10
BMP8A bone morphogenetic protein 8a
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD53 CD53 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDRT1 CMT1A duplicated region transcript 1
CELA2A chymotrypsin-like elastase family, member 2A
CFAP69 cilia and flagella associated protein 69
CLCN6 chloride channel, voltage-sensitive 6
CLDN18 claudin 18
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CSF1R colony stimulating factor 1 receptor
CTSZ cathepsin Z
CXORF21 chromosome X open reading frame 21
DNAI2 dynein, axonemal, intermediate chain 2
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DNASE1L2 deoxyribonuclease I-like 2
DOC2B double C2-like domains, beta
ELL elongation factor RNA polymerase II
EN1 engrailed homeobox 1
EPAS1 endothelial PAS domain protein 1
ERN2 endoplasmic reticulum to nucleus signaling 2
GLS glutaminase
GPR182 G protein-coupled receptor 182
GYG2 glycogenin 2
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HMG20B high mobility group 20B
HOXB2 homeobox B2
IFIH1 interferon induced with helicase C domain 1
IFT54 intraflagellar transport 54
IL1RN interleukin 1 receptor antagonist
ITGA9 integrin, alpha 9
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4
JMJD6 jumonji domain containing 6
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
KIAA1109 KIAA1109
KIF25 kinesin family member 25
KLF12 Kruppel-like factor 12
KLF6 Kruppel-like factor 6
KNG1 kininogen 1
KRT15 keratin 15, type I
KRT23 keratin 23, type I
KSR1 kinase suppressor of ras 1
LMO1 LIM domain only 1 (rhombotin 1)
LRP12 low density lipoprotein receptor-related protein 12
LRRN3 leucine rich repeat neuronal 3
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MARK4 MAP/microtubule affinity-regulating kinase 4
MON2 MON2 homolog (S. cerevisiae)
MPZ myelin protein zero
NTF3 neurotrophin 3
OPRK1 opioid receptor, kappa 1
PGR progesterone receptor
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PLAC4 placenta-specific 4
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLK3 polo-like kinase 3
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRAMEF10 PRAME family member 10
PRB1 proline-rich protein BstNI subfamily 1
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB2A RAB2A, member RAS oncogene family
RAB3B RAB3B, member RAS oncogene family
RAB40AL RAB40A, member RAS oncogene family-like
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAD52 RAD52 homolog (S. cerevisiae)
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RNF126P1 ring finger protein 126 pseudogene 1
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SNCG synuclein, gamma (breast cancer-specific protein 1)
SOS2 son of sevenless homolog 2 (Drosophila)
STAT2 signal transducer and activator of transcription 2, 113kDa
TAOK2 TAO kinase 2
TJAP1 tight junction associated protein 1 (peripheral)
TM4SF4 transmembrane 4 L six family member 4
TNPO2 transportin 2
TP53I11 tumor protein p53 inducible protein 11
TRAF3IP3 TRAF3 interacting protein 3
VIPR1 vasoactive intestinal peptide receptor 1
VNN2 vanin 2
WSCD1 WSC domain containing 1
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF175 zinc finger protein 175
ZNF771 zinc finger protein 771

decreased expression

Symbol Name
ACSL4 acyl-CoA synthetase long-chain family member 4
ADM adrenomedullin
AHNAK2 AHNAK nucleoprotein 2
ALPK1 alpha-kinase 1
ALS2CL ALS2 C-terminal like
ARMC4 armadillo repeat containing 4
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BAHCC1 BAH domain and coiled-coil containing 1
BGLAP bone gamma-carboxyglutamate (gla) protein
C1ORF105 chromosome 1 open reading frame 105
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CALML5 calmodulin-like 5
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCNT1 cyclin T1
CD80 CD80 molecule
CD82 CD82 molecule
CDK18 cyclin-dependent kinase 18
CDKL3 cyclin-dependent kinase-like 3
CHRM3 cholinergic receptor, muscarinic 3
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLCN5 chloride channel, voltage-sensitive 5
CLDN15 claudin 15
CNTN1 contactin 1
COPZ2 coatomer protein complex, subunit zeta 2
CRELD1 cysteine-rich with EGF-like domains 1
DGAT1 diacylglycerol O-acyltransferase 1
DNAH17 dynein, axonemal, heavy chain 17
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DUSP2 dual specificity phosphatase 2
ERCC6 excision repair cross-complementation group 6
EXOC6B exocyst complex component 6B
FAM76A family with sequence similarity 76, member A
FBXL7 F-box and leucine-rich repeat protein 7
FBXO2 F-box protein 2
FLJ11710 uncharacterized protein FLJ11710
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GLB1L2 galactosidase, beta 1-like 2
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GRB7 growth factor receptor-bound protein 7
HIST1H2BC histone cluster 1, H2bc
IL12RB1 interleukin 12 receptor, beta 1
ITGA10 integrin, alpha 10
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KAT2A K(lysine) acetyltransferase 2A
KDM8 lysine (K)-specific demethylase 8
KIAA0894 KIAA0894 protein
KIAA1107 KIAA1107
KLF2 Kruppel-like factor 2
KRT13 keratin 13, type I
LARP6 La ribonucleoprotein domain family, member 6
LINC00339 long intergenic non-protein coding RNA 339
LMO2 LIM domain only 2 (rhombotin-like 1)
MALL mal, T-cell differentiation protein-like
MAPK12 mitogen-activated protein kinase 12
MBTD1 mbt domain containing 1
MFSD11 major facilitator superfamily domain containing 11
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MTCP1 mature T-cell proliferation 1
NIPAL2 NIPA-like domain containing 2
NME5 NME/NM23 family member 5
NOD1 nucleotide-binding oligomerization domain containing 1
NOL12 nucleolar protein 12
NUPL2 nucleoporin like 2
OLFML2A olfactomedin-like 2A
OSGIN1 oxidative stress induced growth inhibitor 1
PCSK7 proprotein convertase subtilisin/kexin type 7
PLA2G3 phospholipase A2, group III
PLEKHA6 pleckstrin homology domain containing, family A member 6
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRAMEF11 PRAME family member 11
PRDM16 PR domain containing 16
PRR4 proline rich 4 (lacrimal)
PYHIN1 pyrin and HIN domain family, member 1
RAB30 RAB30, member RAS oncogene family
RAB3A RAB3A, member RAS oncogene family
RNF43 ring finger protein 43
RPH3AL rabphilin 3A-like (without C2 domains)
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRAGB Ras-related GTP binding B
S100A9 S100 calcium binding protein A9
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC44A1 solute carrier family 44 (choline transporter), member 1
SMIM14 small integral membrane protein 14
TAOK1 TAO kinase 1
TBKBP1 TBK1 binding protein 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TFF2 trefoil factor 2
TMEM45A transmembrane protein 45A
TRIM36 tripartite motif containing 36
WDR62 WD repeat domain 62
ZIC3 Zic family member 3
ZNF408 zinc finger protein 408
ZNF652 zinc finger protein 652
ZNF816 zinc finger protein 816
ZNF862 zinc finger protein 862