rb1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description retinoblastoma 1|The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5925)
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Genes

42 genes co-occuring with the biological term rb1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AGO2 argonaute RISC catalytic component 2
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
CCND1 cyclin D1
CCND2 cyclin D2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDK8 cyclin-dependent kinase 8
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
E2F1 E2F transcription factor 1
ESR1 estrogen receptor 1
GADD45A growth arrest and DNA-damage-inducible, alpha
HLX H2.0-like homeobox
HUS1 HUS1 checkpoint homolog (S. pombe)
KEAP1 kelch-like ECH-associated protein 1
KMT2D lysine (K)-specific methyltransferase 2D
LIMD1 LIM domains containing 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MGMT O-6-methylguanine-DNA methyltransferase
MIR106A microRNA 106a
MIR215 microRNA 215
MIRLET7A1 microRNA let-7a-1
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NFE2L2 nuclear factor, erythroid 2-like 2
PER2 period circadian clock 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R26P1 protein phosphatase 1, regulatory subunit 26 pseudogene 1
PRMT5 protein arginine methyltransferase 5
PTEN phosphatase and tensin homolog
RB1 retinoblastoma 1
RB1CC1 RB1-inducible coiled-coil 1
RBL1 retinoblastoma-like 1
RBL2 retinoblastoma-like 2
SMYD2 SET and MYND domain containing 2
TBX2 T-box 2
TP53 tumor protein p53