rcc Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A carcinoma arising from the renal parenchyma. The incidence of renal cell carcinoma has increased by 35% from 1973 to 1991. There is a strong correlation between cigarette smoking and the development of renal cell carcinoma. The clinical presentation includes : hematuria, flank pain and a palpable lumbar mass. A high percentage of renal cell carcinomas are diagnosed when an ultrasound is performed for other purposes. Diagnostic procedures include: ultra sound, intravenous pyelography and computed tomography (CT). Radical nephrectomy is the standard intervention procedure. Renal cell carcinoma is generally considered to be resistant to radiation treatment and chemotherapy.|A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma. (Experimental Factor Ontology, EFO_0000681)
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Genes

175 genes co-occuring with the biological term rcc in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALOX15B arachidonate 15-lipoxygenase, type B
AP1M2 adaptor-related protein complex 1, mu 2 subunit
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AXL AXL receptor tyrosine kinase
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BSG basigin (Ok blood group)
C19ORF33 chromosome 19 open reading frame 33
CA9 carbonic anhydrase IX
CARD10 caspase recruitment domain family, member 10
CAV1 caveolin 1, caveolae protein, 22kDa
CBX5 chromobox homolog 5
CCL2 chemokine (C-C motif) ligand 2
CCL7 chemokine (C-C motif) ligand 7
CCNA2 cyclin A2
CCNB1 cyclin B1
CCR2 chemokine (C-C motif) receptor 2
CD40 CD40 molecule, TNF receptor superfamily member 5
CDK2 cyclin-dependent kinase 2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
COL1A1 collagen, type I, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CRP C-reactive protein, pentraxin-related
CSF1 colony stimulating factor 1 (macrophage)
CSF1R colony stimulating factor 1 receptor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL16 chemokine (C-X-C motif) ligand 16
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
EBAG9 estrogen receptor binding site associated, antigen, 9
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EGLN3 egl-9 family hypoxia-inducible factor 3
ELAVL1 ELAV like RNA binding protein 1
EPAS1 endothelial PAS domain protein 1
ESRP1 epithelial splicing regulatory protein 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FGF2 fibroblast growth factor 2 (basic)
FGFR3 fibroblast growth factor receptor 3
FLNA filamin A, alpha
FN1 fibronectin 1
FRZB frizzled-related protein
FXYD5 FXYD domain containing ion transport regulator 5
GAS6 growth arrest-specific 6
GJB1 gap junction protein, beta 1, 32kDa
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GOLPH3 golgi phosphoprotein 3 (coat-protein)
GRM1 glutamate receptor, metabotropic 1
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HAVCR2 hepatitis A virus cellular receptor 2
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HK2 hexokinase 2
HPN hepsin
HSPA1B heat shock 70kDa protein 1B
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IL16 interleukin 16
IL4R interleukin 4 receptor
IRF8 interferon regulatory factor 8
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JADE1 jade family PHD finger 1
JAK2 Janus kinase 2
KDR kinase insert domain receptor
KISS1R KISS1 receptor
KLLN killin, p53-regulated DNA replication inhibitor
KRAS Kirsten rat sarcoma viral oncogene homolog
LEF1 lymphoid enhancer-binding factor 1
LTF lactotransferrin
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene)
MAPK8 mitogen-activated protein kinase 8
MAPKAP1 mitogen-activated protein kinase associated protein 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MIR100 microRNA 100
MIR101-1 microRNA 101-1
MIR1291 microRNA 1291
MIR143 microRNA 143
MIR145 microRNA 145
MIR185 microRNA 185
MIR192 microRNA 192
MIR194-1 microRNA 194-1
MIR194-2 microRNA 194-2
MIR199A1 microRNA 199a-1
MIR21 microRNA 21
MIR215 microRNA 215
MIR508 microRNA 508
MIR509-3 microRNA 509-3
MIR7-1 microRNA 7-1
MIR7-2 microRNA 7-2
MIR7-3 microRNA 7-3
MIRLET7A1 microRNA let-7a-1
MLH1 mutL homolog 1
MME membrane metallo-endopeptidase
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP7 matrix metallopeptidase 7
MSH2 mutS homolog 2
MTDH metadherin
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEFH neurofilament, heavy polypeptide
NOV nephroblastoma overexpressed
NOX4 NADPH oxidase 4
PAX2 paired box 2
PAX8 paired box 8
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PEBP1 phosphatidylethanolamine binding protein 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PROM2 prominin 2
PRSS8 protease, serine, 8
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTMA prothymosin, alpha
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
ROR2 receptor tyrosine kinase-like orphan receptor 2
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
RUNX3 runt-related transcription factor 3
RXRA retinoid X receptor, alpha
SDC4 syndecan 4
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SEMG1 semenogelin I
SFRP1 secreted frizzled-related protein 1
SFRP2 secreted frizzled-related protein 2
SHH sonic hedgehog
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC38A3 solute carrier family 38, member 3
SLC39A10 solute carrier family 39 (zinc transporter), member 10
SPAG4 sperm associated antigen 4
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK11 serine/threonine kinase 11
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TFE3 transcription factor binding to IGHM enhancer 3
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
THBS1 thrombospondin 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TRPC4 transient receptor potential cation channel, subfamily C, member 4
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum)
TYMS thymidylate synthetase
UNC5C unc-5 homolog C (C. elegans)
VEGFA vascular endothelial growth factor A
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VTCN1 V-set domain containing T cell activation inhibitor 1
WNT3A wingless-type MMTV integration site family, member 3A
WNT7A wingless-type MMTV integration site family, member 7A
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZEB2 zinc finger E-box binding homeobox 2