receptor internalization Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane. (Gene Ontology, GO_0031623)
External Link http://amigo.geneontology.org/amigo/term/GO:0031623
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Genes

57 genes participating in the receptor internalization biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AP2M1 adaptor-related protein complex 2, mu 1 subunit
ARR3 arrestin 3, retinal (X-arrestin)
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
C1D C1D nuclear receptor corepressor
CALCA calcitonin-related polypeptide alpha
CALCRL calcitonin receptor-like
CAV1 caveolin 1, caveolae protein, 22kDa
CAV3 caveolin 3
CD36 CD36 molecule (thrombospondin receptor)
CD81 CD81 molecule
CD9 CD9 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CLTC clathrin, heavy chain (Hc)
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR1 chemokine (C-X-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
DNM1 dynamin 1
DNM2 dynamin 2
DNM3 dynamin 3
DRD3 dopamine receptor D3
ENTREP1 endosomal transmembrane epsin interactor 1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
GHR growth hormone receptor
GRB2 growth factor receptor-bound protein 2
GRK2 G protein-coupled receptor kinase 2
GRK3 G protein-coupled receptor kinase 3
GRK4 G protein-coupled receptor kinase 4
GTF2H2 general transcription factor IIH, polypeptide 2, 44kDa
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
ITCH itchy E3 ubiquitin protein ligase
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LMBRD1 LMBR1 domain containing 1
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
PICALM phosphatidylinositol binding clathrin assembly protein
RAB31 RAB31, member RAS oncogene family
RAB5A RAB5A, member RAS oncogene family
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RALB v-ral simian leukemia viral oncogene homolog B
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RAMP2 receptor (G protein-coupled) activity modifying protein 2
RAMP3 receptor (G protein-coupled) activity modifying protein 3
RNF7 ring finger protein 7
SCYL2 SCY1-like 2 (S. cerevisiae)
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX1 sorting nexin 1
SYK spleen tyrosine kinase
TFRC transferrin receptor