receptor-mediated endocytosis Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles. (Gene Ontology, GO_0006898)
External Link http://amigo.geneontology.org/amigo/term/GO:0006898
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Genes

137 genes participating in the receptor-mediated endocytosis biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ACE2 angiotensin I converting enzyme 2
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AMN amnion associated transmembrane protein
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
AP2A1 adaptor-related protein complex 2, alpha 1 subunit
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AP2M1 adaptor-related protein complex 2, mu 1 subunit
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
APOE apolipoprotein E
ARHGAP27 Rho GTPase activating protein 27
ARRB2 arrestin, beta 2
ASGR1 asialoglycoprotein receptor 1
C1D C1D nuclear receptor corepressor
CALCA calcitonin-related polypeptide alpha
CALCRL calcitonin receptor-like
CANX calnexin
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD36 CD36 molecule (thrombospondin receptor)
CD81 CD81 molecule
CD9 CD9 molecule
CLEC4M C-type lectin domain family 4, member M
CLEC9A C-type lectin domain family 9, member A
CLN3 ceroid-lipofuscinosis, neuronal 3
CLTA clathrin, light chain A
CLTB clathrin, light chain B
CLTC clathrin, heavy chain (Hc)
CLTCL1 clathrin, heavy chain-like 1
CTSL cathepsin L
CTTN cortactin
CUBN cubilin (intrinsic factor-cobalamin receptor)
CXCL16 chemokine (C-X-C motif) ligand 16
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR1 chemokine (C-X-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DLL1 delta-like 1 (Drosophila)
DMBT1 deleted in malignant brain tumors 1
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DNM1 dynamin 1
DNM2 dynamin 2
DNM3 dynamin 3
DPP4 dipeptidyl-peptidase 4
ENTREP1 endosomal transmembrane epsin interactor 1
EPS15 epidermal growth factor receptor pathway substrate 15
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCHO1 FCH domain only 1
FCHO2 FCH domain only 2
FCHSD2 FCH and double SH3 domains 2
FNBP1L formin binding protein 1-like
FOLR2 folate receptor 2 (fetal)
GAK cyclin G associated kinase
GAS7 growth arrest-specific 7
GHR growth hormone receptor
GPR107 G protein-coupled receptor 107
GRB2 growth factor receptor-bound protein 2
GRK2 G protein-coupled receptor kinase 2
GRK3 G protein-coupled receptor kinase 3
GRK4 G protein-coupled receptor kinase 4
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HIP1R huntingtin interacting protein 1 related
HSPG2 heparan sulfate proteoglycan 2
IGF2R insulin-like growth factor 2 receptor
INPP5F inositol polyphosphate-5-phosphatase F
INSR insulin receptor
ITCH itchy E3 ubiquitin protein ligase
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
LDLR low density lipoprotein receptor
LDLRAD3 low density lipoprotein receptor class A domain containing 3
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LMBR1L limb development membrane protein 1-like
LMBRD1 LMBR1 domain containing 1
LRP1B low density lipoprotein receptor-related protein 1B
LRP2 low density lipoprotein receptor-related protein 2
LRP3 low density lipoprotein receptor-related protein 3
M6PR mannose-6-phosphate receptor (cation dependent)
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MARCO macrophage receptor with collagenous structure
MICALL1 MICAL-like 1
MRC1 mannose receptor, C type 1
MSR1 macrophage scavenger receptor 1
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NLGN3 neuroligin 3
PDLIM7 PDZ and LIM domain 7 (enigma)
PI4KB phosphatidylinositol 4-kinase, catalytic, beta
PICALM phosphatidylinositol binding clathrin assembly protein
PIKFYVE phosphoinositide kinase, FYVE finger containing
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLA2R1 phospholipase A2 receptor 1, 180kDa
PLXNB2 plexin B2
PPT1 palmitoyl-protein thioesterase 1
RAB15 RAB15, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
RAB5A RAB5A, member RAS oncogene family
RAB9A RAB9A, member RAS oncogene family
RAB9B RAB9B, member RAS oncogene family
RABEPK Rab9 effector protein with kelch motifs
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RALB v-ral simian leukemia viral oncogene homolog B
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RAMP2 receptor (G protein-coupled) activity modifying protein 2
RAMP3 receptor (G protein-coupled) activity modifying protein 3
REPS1 RALBP1 associated Eps domain containing 1
RNASEK ribonuclease, RNase K
SCARB2 scavenger receptor class B, member 2
SCARF1 scavenger receptor class F, member 1
SCYL2 SCY1-like 2 (S. cerevisiae)
SFTPD surfactant protein D
SNAP91 synaptosomal-associated protein, 91kDa
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX1 sorting nexin 1
SNX9 sorting nexin 9
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STAB1 stabilin 1
STAB2 stabilin 2
STON1 stonin 1
STON2 stonin 2
SYK spleen tyrosine kinase
TFR2 transferrin receptor 2
TFRC transferrin receptor
TMEM108 transmembrane protein 108
TPCN2 two pore segment channel 2
VLDLR very low density lipoprotein receptor
WASF1 WAS protein family, member 1