regulation of ERK1 and ERK2 cascade Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. (Gene Ontology, GO_0070372)
External Link http://amigo.geneontology.org/amigo/term/GO:0070372
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Genes

224 genes participating in the regulation of ERK1 and ERK2 cascade biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACKR3 atypical chemokine receptor 3
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRA1A adrenoceptor alpha 1A
AGER advanced glycosylation end product-specific receptor
ALKAL1 ALK and LTK ligand 1
ALKAL2 ALK and LTK ligand 2
ALOX15 arachidonate 15-lipoxygenase
ANGPT1 angiopoietin 1
APELA apelin receptor early endogenous ligand
APIP APAF1 interacting protein
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
ARHGAP8 Rho GTPase activating protein 8
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
BMP2 bone morphogenetic protein 2
BMPER BMP binding endothelial regulator
BRAF B-Raf proto-oncogene, serine/threonine kinase
C5AR1 complement component 5a receptor 1
CALCR calcitonin receptor
CARD9 caspase recruitment domain family, member 9
CCL19 chemokine (C-C motif) ligand 19
CCL21 chemokine (C-C motif) ligand 21
CCL3 chemokine (C-C motif) ligand 3
CCN2 cellular communication network factor 2
CCR1 chemokine (C-C motif) receptor 1
CCR7 chemokine (C-C motif) receptor 7
CD36 CD36 molecule (thrombospondin receptor)
CD4 CD4 molecule
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
CIB1 calcium and integrin binding 1 (calmyrin)
CNKSR3 CNKSR family member 3
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSF1R colony stimulating factor 1 receptor
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL17 chemokine (C-X-C motif) ligand 17
DAB2IP DAB2 interacting protein
DDTL D-dopachrome tautomerase-like
DENND2B DENN domain containing 2B
DLG1 discs, large homolog 1 (Drosophila)
DSTYK dual serine/threonine and tyrosine protein kinase
DUSP10 dual specificity phosphatase 10
DUSP15 dual specificity phosphatase 15
DUSP28 dual specificity phosphatase 28
DUSP29 dual specificity phosphatase 29
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
DUSP9 dual specificity phosphatase 9
EGFR epidermal growth factor receptor
EMILIN1 elastin microfibril interfacer 1
EPHA2 EPH receptor A2
EPHA4 EPH receptor A4
EPHA7 EPH receptor A7
EPHB1 EPH receptor B1
EPHB2 EPH receptor B2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
EZR ezrin
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBLN1 fibulin 1
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FERMT2 fermitin family member 2
FFAR4 free fatty acid receptor 4
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGF1 fibroblast growth factor 1 (acidic)
FGF13 fibroblast growth factor 13
FGF19 fibroblast growth factor 19
FGF21 fibroblast growth factor 21
FGF4 fibroblast growth factor 4
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FGG fibrinogen gamma chain
FLCN folliculin
FLT4 fms-related tyrosine kinase 4
FN1 fibronectin 1
FPR2 formyl peptide receptor 2
FSHR follicle stimulating hormone receptor
GAREM1 GRB2 associated regulator of MAPK1 subtype 1
GAS6 growth arrest-specific 6
GBP1 guanylate binding protein 1, interferon-inducible
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GLIPR2 GLI pathogenesis-related 2
GPER1 G protein-coupled estrogen receptor 1
GPNMB glycoprotein (transmembrane) nmb
GPR183 G protein-coupled receptor 183
GPR55 G protein-coupled receptor 55
GSTP1 glutathione S-transferase pi 1
HAND2 heart and neural crest derivatives expressed 2
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGB1 high mobility group box 1
HRAS Harvey rat sarcoma viral oncogene homolog
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IAPP islet amyloid polypeptide
ICAM1 intercellular adhesion molecule 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL26 interleukin 26
ITGB1BP1 integrin beta 1 binding protein 1
KDR kinase insert domain receptor
LGALS9 lectin, galactoside-binding, soluble, 9
LMO3 LIM domain only 3 (rhombotin-like 2)
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAPK3 mitogen-activated protein kinase 3
MARCO macrophage receptor with collagenous structure
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MISO1 mitochondrial inner membrane subdomain organizer 1
MOCOS molybdenum cofactor sulfurase
MT3 metallothionein 3
MTURN maturin, neural progenitor differentiation regulator homolog (Xenopus)
NAMPT nicotinamide phosphoribosyltransferase
NDRG4 NDRG family member 4
NECAB2 N-terminal EF-hand calcium binding protein 2
NEK10 NIMA-related kinase 10
NOD2 nucleotide-binding oligomerization domain containing 2
NODAL nodal growth differentiation factor
NOTCH1 notch 1
NOTCH2 notch 2
NPNT nephronectin
NRG1 neuregulin 1
NRP1 neuropilin 1
NRXN1 neurexin 1
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
OPRM1 opioid receptor, mu 1
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PDE8A phosphodiesterase 8A
PDE8B phosphodiesterase 8B
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDGFC platelet derived growth factor C
PDGFD platelet derived growth factor D
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDZD2 PDZ domain containing 2
PHB1 prohibitin 1
PHB2 prohibitin 2
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G5 phospholipase A2, group V
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKCA protein kinase C, alpha
PRKCZ protein kinase C, zeta
PRKD2 protein kinase D2
PRXL2C peroxiredoxin like 2C
PSCA prostate stem cell antigen
PTK2B protein tyrosine kinase 2 beta
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRR protein tyrosine phosphatase, receptor type, R
PYCARD PYD and CARD domain containing
RAMP3 receptor (G protein-coupled) activity modifying protein 3
RANBP9 RAN binding protein 9
RAP1A RAP1A, member of RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGS14 regulator of G-protein signaling 14
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
RRAS related RAS viral (r-ras) oncogene homolog
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SACK1D scaffolding CK1 anchoring protein D
SCIMP SLP adaptor and CSK interacting membrane protein
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIRPA signal-regulatory protein alpha
SLAMF1 signaling lymphocytic activation molecule family member 1
SLC30A10 solute carrier family 30, member 10
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMAD4 SMAD family member 4
SPRED1 sprouty-related, EVH1 domain containing 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRED3 sprouty-related, EVH1 domain containing 3
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY3 sprouty homolog 3 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STYX serine/threonine/tyrosine interacting protein
SYK spleen tyrosine kinase
SYNJ2BP synaptojanin 2 binding protein
TEK TEK tyrosine kinase, endothelial
TGFB1 transforming growth factor, beta 1
TGFBR3 transforming growth factor, beta receptor III
THPO thrombopoietin
TIPE3 TNF alpha induced protein 8 like 3
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNIP1 TNFAIP3 interacting protein 1
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase
TREM2 triggering receptor expressed on myeloid cells 2
VEGFA vascular endothelial growth factor A
VEGFB vascular endothelial growth factor B
WNK2 WNK lysine deficient protein kinase 2
XBP1 X-box binding protein 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZDHHC17 zinc finger, DHHC-type containing 17