regulation of MAPK cascade Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade. (Gene Ontology, GO_0043408)
External Link http://amigo.geneontology.org/amigo/term/GO:0043408
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Genes

261 genes participating in the regulation of MAPK cascade biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADAM8 ADAM metallopeptidase domain 8
ADRA1A adrenoceptor alpha 1A
ADRA1B adrenoceptor alpha 1B
ADRA1D adrenoceptor alpha 1D
ADRA2A adrenoceptor alpha 2A
ADRA2B adrenoceptor alpha 2B
ADRA2C adrenoceptor alpha 2C
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGER advanced glycosylation end product-specific receptor
ALOX12B arachidonate 12-lipoxygenase, 12R type
APIP APAF1 interacting protein
APP amyloid beta (A4) precursor protein
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
AVPI1 arginine vasopressin-induced 1
AVPR1B arginine vasopressin receptor 1B
BCAR3 breast cancer anti-estrogen resistance 3
BMP2 bone morphogenetic protein 2
BUB1B-PAK6 BUB1B-PAK6 readthrough
CARTPT CART prepropeptide
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CAV3 caveolin 3
CCM2 cerebral cavernous malformation 2
CD24 CD24 molecule
CD4 CD4 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD81 CD81 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
CLEC7A C-type lectin domain family 7, member A
COPS5 COP9 signalosome subunit 5
CRIPTO3 cripto, EGF-CFC family member 3
CSF1R colony stimulating factor 1 receptor
CX3CL1 chemokine (C-X3-C motif) ligand 1
DAB2IP DAB2 interacting protein
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DHX33 DEAH (Asp-Glu-Ala-His) box polypeptide 33
DRD1 dopamine receptor D1
DRD5 dopamine receptor D5
DUSP12 dual specificity phosphatase 12
DUSP13B dual specificity phosphatase 13B
DUSP16 dual specificity phosphatase 16
DUSP19 dual specificity phosphatase 19
DUSP2 dual specificity phosphatase 2
DUSP28 dual specificity phosphatase 28
DUSP29 dual specificity phosphatase 29
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP8 dual specificity phosphatase 8
EDN1 endothelin 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EPGN epithelial mitogen
EPHA2 EPH receptor A2
EPHA7 EPH receptor A7
EPHA8 EPH receptor A8
EPHB1 EPH receptor B1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
ERP29 endoplasmic reticulum protein 29
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FASN fatty acid synthase
FCRL3 Fc receptor-like 3
FGF1 fibroblast growth factor 1 (acidic)
FGF10 fibroblast growth factor 10
FGF13 fibroblast growth factor 13
FGF16 fibroblast growth factor 16
FGF17 fibroblast growth factor 17
FGF18 fibroblast growth factor 18
FGF19 fibroblast growth factor 19
FGF20 fibroblast growth factor 20
FGF21 fibroblast growth factor 21
FGF22 fibroblast growth factor 22
FGF23 fibroblast growth factor 23
FGF3 fibroblast growth factor 3
FGF4 fibroblast growth factor 4
FGF5 fibroblast growth factor 5
FGF6 fibroblast growth factor 6
FGF7 fibroblast growth factor 7
FGF8 fibroblast growth factor 8 (androgen-induced)
FGF9 fibroblast growth factor 9
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FLT1 fms-related tyrosine kinase 1
FLT3 fms-related tyrosine kinase 3
FLT4 fms-related tyrosine kinase 4
FN1 fibronectin 1
FZD7 frizzled class receptor 7
GBA1 glucosylceramidase beta 1
GDF15 growth differentiation factor 15
GFRAL GDNF family receptor alpha like
GHRL ghrelin/obestatin prepropeptide
GPER1 G protein-coupled estrogen receptor 1
GPR101 G protein-coupled receptor 101
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPR37L1 G protein-coupled receptor 37 like 1
GRAP GRB2-related adaptor protein
GRAP2 GRB2-related adaptor protein 2
GRB2 growth factor receptor-bound protein 2
GREM1 gremlin 1, DAN family BMP antagonist
GRM4 glutamate receptor, metabotropic 4
GSDME gasdermin E
GSTP1 glutathione S-transferase pi 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGB1 high mobility group box 1
HRAS Harvey rat sarcoma viral oncogene homolog
IAPP islet amyloid polypeptide
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGFBP6 insulin-like growth factor binding protein 6
IL11 interleukin 11
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL6 interleukin 6
IL6R interleukin 6 receptor
INAVA innate immunity activator
INS insulin
INSR insulin receptor
IQGAP1 IQ motif containing GTPase activating protein 1
JCAD junctional cadherin 5 associated
KCTD11 potassium channel tetramerization domain containing 11
KDR kinase insert domain receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KSR1 kinase suppressor of ras 1
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
LAPTM5 lysosomal protein transmembrane 5
LAX1 lymphocyte transmembrane adaptor 1
LEP leptin
LGALS9 lectin, galactoside-binding, soluble, 9
LIF leukemia inhibitory factor
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LPAR1 lysophosphatidic acid receptor 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MADD MAP-kinase activating death domain
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MDFI MyoD family inhibitor
MDFIC MyoD family inhibitor domain containing
MDFIC2 MyoD family inhibitor domain containing 2
MEF2C myocyte enhancer factor 2C
MINK1 misshapen-like kinase 1
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MOCOS molybdenum cofactor sulfurase
MYDGF myeloid-derived growth factor
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NBR1 neighbor of BRCA1 gene 1
NEK10 NIMA-related kinase 10
NF1 neurofibromin 1
NOD2 nucleotide-binding oligomerization domain containing 2
NTF3 neurotrophin 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PAGE4 P antigen family, member 4 (prostate associated)
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PEBP1 phosphatidylethanolamine binding protein 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PELI2 pellino E3 ubiquitin protein ligase family member 2
PER1 period circadian clock 1
PHB2 prohibitin 2
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive)
PKN1 protein kinase N1
PKN2 protein kinase N2
PLA2G1B phospholipase A2, group IB (pancreas)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PP2D1 protein phosphatase 2C-like domain containing 1
PPARG peroxisome proliferator-activated receptor gamma
PPEF2 protein phosphatase, EF-hand calcium binding domain 2
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRDM11 PR domain containing 11
PRDM15 PR domain containing 15
PRKCD protein kinase C, delta
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRJ protein tyrosine phosphatase, receptor type, J
RAP2A RAP2A, member of RAS oncogene family
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RET ret proto-oncogene
RIT2 Ras-like without CAAX 2
RNASE3 ribonuclease, RNase A family, 3
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
RRAS related RAS viral (r-ras) oncogene homolog
RYK receptor-like tyrosine kinase
SACK1D scaffolding CK1 anchoring protein D
SBNO1 strawberry notch homolog 1 (Drosophila)
SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
SH2B3 SH2B adaptor protein 3
SH3GL2 SH3-domain GRB2-like 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHOC2 soc-2 suppressor of clear homolog (C. elegans)
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SMIM29 small integral membrane protein 29
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SOD1 superoxide dismutase 1, soluble
SOS1 son of sevenless homolog 1 (Drosophila)
SOX2 SRY (sex determining region Y)-box 2
SPNS1 spinster homolog 1 (Drosophila)
SPRED1 sprouty-related, EVH1 domain containing 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY3 sprouty homolog 3 (Drosophila)
STK24 serine/threonine kinase 24
STK4 serine/threonine kinase 4
STK40 serine/threonine kinase 40
STYX serine/threonine/tyrosine interacting protein
STYXL2 serine/threonine/tyrosine interacting like 2
SYK spleen tyrosine kinase
TAOK2 TAO kinase 2
TAOK3 TAO kinase 3
TBX1 T-box 1
TEK TEK tyrosine kinase, endothelial
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
TGFBR3 transforming growth factor, beta receptor III
THPO thrombopoietin
TLR9 toll-like receptor 9
TMEM106A transmembrane protein 106A
TNF tumor necrosis factor
TNIK TRAF2 and NCK interacting kinase
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase
TRIM5 tripartite motif containing 5
ULK4 unc-51 like kinase 4
VEGFA vascular endothelial growth factor A
VRK2 vaccinia related kinase 2
WDR54 WD repeat domain 54
WNT4 wingless-type MMTV integration site family, member 4
WNT5A wingless-type MMTV integration site family, member 5A
WWC1 WW and C2 domain containing 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZDHHC17 zinc finger, DHHC-type containing 17
ZNF622 zinc finger protein 622