regulation of defense response Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description Any process that modulates the frequency, rate or extent of a defense response. (Gene Ontology, GO_0031347)
External Link http://amigo.geneontology.org/amigo/term/GO:0031347
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Genes

104 genes participating in the regulation of defense response biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ACE2 angiotensin I converting enzyme 2
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
AGER advanced glycosylation end product-specific receptor
AGTR1 angiotensin II receptor, type 1
AHSG alpha-2-HS-glycoprotein
AKNA AT-hook transcription factor
ALOX15 arachidonate 15-lipoxygenase
ALOX5 arachidonate 5-lipoxygenase
ANXA1 annexin A1
APOE apolipoprotein E
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1
ARMH4 armadillo like helical domain containing 4
BCL6 B-cell CLL/lymphoma 6
BCL6B B-cell CLL/lymphoma 6, member B
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BRD4 bromodomain containing 4
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCR2 chemokine (C-C motif) receptor 2
CD300A CD300a molecule
CD300C CD300c molecule
CD300E CD300e molecule
CELF1 CUGBP, Elav-like family member 1
CMA1 chymase 1, mast cell
CYLD cylindromatosis (turban tumor syndrome)
DAGLB diacylglycerol lipase, beta
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
ELMOD2 ELMO/CED-12 domain containing 2
ERAP1 endoplasmic reticulum aminopeptidase 1
FBXL2 F-box and leucine-rich repeat protein 2
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FGR FGR proto-oncogene, Src family tyrosine kinase
FMNL1-AS1 FMNL1 antisense RNA 1
FOXP1 forkhead box P1
GATA6 GATA binding protein 6
GGT1 gamma-glutamyltransferase 1
GRN granulin
HCK HCK proto-oncogene, Src family tyrosine kinase
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
IFI16 interferon, gamma-inducible protein 16
IL1R1 interleukin 1 receptor, type I
IL20 interleukin 20
IL36R interleukin 36 receptor
IL37 interleukin 37
IRF1 interferon regulatory factor 1
JAK2 Janus kinase 2
LACC1 laccase (multicopper oxidoreductase) domain containing 1
LETMD1 LETM1 domain containing 1
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LRRC19 leucine rich repeat containing 19
MGLL monoglyceride lipase
MYD88 myeloid differentiation primary response 88
N4BP1 NEDD4 binding protein 1
NFE2L2 nuclear factor, erythroid 2-like 2
NLRP1 NLR family, pyrin domain containing 1
NLRP10 NLR family, pyrin domain containing 10
NLRP11 NLR family, pyrin domain containing 11
NLRP12 NLR family, pyrin domain containing 12
NLRP13 NLR family, pyrin domain containing 13
NLRP14 NLR family, pyrin domain containing 14
NLRP2 NLR family, pyrin domain containing 2
NLRP3 NLR family, pyrin domain containing 3
NLRP4 NLR family, pyrin domain containing 4
NLRP5 NLR family, pyrin domain containing 5
NLRP6 NLR family, pyrin domain containing 6
NLRP7 NLR family, pyrin domain containing 7
NLRP8 NLR family, pyrin domain containing 8
NLRP9 NLR family, pyrin domain containing 9
NOD2 nucleotide-binding oligomerization domain containing 2
NR1D2 nuclear receptor subfamily 1, group D, member 2
PARK7 parkinson protein 7
PGAP1 post-GPI attachment to proteins 1
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PTGES prostaglandin E synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PYCARD PYD and CARD domain containing
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RNF135 ring finger protein 135
SAMHD1 SAM domain and HD domain 1
SBNO2 strawberry notch homolog 2 (Drosophila)
SELE selectin E
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SETD6 SET domain containing 6
SHPK sedoheptulokinase
SPATA2 spermatogenesis associated 2
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TKFC triokinase/FMN cyclase
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNNC1 troponin C type 1 (slow)
TRAF3 TNF receptor-associated factor 3
TREM2 triggering receptor expressed on myeloid cells 2
UFL1 UFM1-specific ligase 1
USP18 ubiquitin specific peptidase 18
WNT5A wingless-type MMTV integration site family, member 5A
XCL1 chemokine (C motif) ligand 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZBP1 Z-DNA binding protein 1
ZMPSTE24 zinc metallopeptidase STE24