regulation of intracellular signal transduction Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description Any process that modulates the frequency, rate or extent of intracellular signal transduction. (Gene Ontology, GO_1902531)
External Link http://amigo.geneontology.org/amigo/term/GO:1902531
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Genes

303 genes participating in the regulation of intracellular signal transduction biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ABR active BCR-related
ACVR1 activin A receptor, type I
AGER advanced glycosylation end product-specific receptor
AKAP12 A kinase (PRKA) anchor protein 12
AKAP13 A kinase (PRKA) anchor protein 13
AKAP5 A kinase (PRKA) anchor protein 5
AKAP6 A kinase (PRKA) anchor protein 6
AKR1C3 aldo-keto reductase family 1, member C3
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALOX15 arachidonate 15-lipoxygenase
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANKRD54 ankyrin repeat domain 54
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARHGAP1 Rho GTPase activating protein 1
ARHGAP10 Rho GTPase activating protein 10
ARHGAP11A Rho GTPase activating protein 11A
ARHGAP11B Rho GTPase activating protein 11B
ARHGAP15 Rho GTPase activating protein 15
ARHGAP18 Rho GTPase activating protein 18
ARHGAP19 Rho GTPase activating protein 19
ARHGAP20 Rho GTPase activating protein 20
ARHGAP21 Rho GTPase activating protein 21
ARHGAP22 Rho GTPase activating protein 22
ARHGAP23 Rho GTPase activating protein 23
ARHGAP26 Rho GTPase activating protein 26
ARHGAP27 Rho GTPase activating protein 27
ARHGAP28 Rho GTPase activating protein 28
ARHGAP29 Rho GTPase activating protein 29
ARHGAP30 Rho GTPase activating protein 30
ARHGAP31 Rho GTPase activating protein 31
ARHGAP32 Rho GTPase activating protein 32
ARHGAP35 Rho GTPase activating protein 35
ARHGAP39 Rho GTPase activating protein 39
ARHGAP4 Rho GTPase activating protein 4
ARHGAP40 Rho GTPase activating protein 40
ARHGAP44 Rho GTPase activating protein 44
ARHGAP45 Rho GTPase activating protein 45
ARHGAP5 Rho GTPase activating protein 5
ARHGAP6 Rho GTPase activating protein 6
ARHGAP8 Rho GTPase activating protein 8
ARHGAP9 Rho GTPase activating protein 9
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARHGEF19 Rho guanine nucleotide exchange factor (GEF) 19
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
ATM ATM serine/threonine kinase
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
AURKA aurora kinase A
AURKB aurora kinase B
BCL3 B-cell CLL/lymphoma 3
BCR breakpoint cluster region
BMP6 bone morphogenetic protein 6
BOP1 block of proliferation 1
BUB1B-PAK6 BUB1B-PAK6 readthrough
CALM2 calmodulin 2 (phosphorylase kinase, delta)
CAPN3 calpain 3, (p94)
CD24 CD24 molecule
CDH5 cadherin 5, type 2 (vascular endothelium)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHN1 chimerin 1
CLEC6A C-type lectin domain family 6, member A
CLEC7A C-type lectin domain family 7, member A
CMKLR1 chemerin chemokine-like receptor 1
CPNE1 copine I
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRNN cornulin
CSF1R colony stimulating factor 1 receptor
CTNND1 catenin (cadherin-associated protein), delta 1
CYLD cylindromatosis (turban tumor syndrome)
DAB2IP DAB2 interacting protein
DAPK2 death-associated protein kinase 2
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DHRS3 dehydrogenase/reductase (SDR family) member 3
DIPK2A divergent protein kinase domain 2A
DLC1 DLC1 Rho GTPase activating protein
DLG1 discs, large homolog 1 (Drosophila)
DNMBP dynamin binding protein
DOCK2 dedicator of cytokinesis 2
DOCK3 dedicator of cytokinesis 3
DOCK8 dedicator of cytokinesis 8
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
ECT2 epithelial cell transforming 2
EDA ectodysplasin A
EFNA1 ephrin-A1
EP300 E1A binding protein p300
EPHA4 EPH receptor A4
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM13A family with sequence similarity 13, member A
FAM13B family with sequence similarity 13, member B
FBXL2 F-box and leucine-rich repeat protein 2
FBXO9 F-box protein 9
FGD1 FYVE, RhoGEF and PH domain containing 1
FGD2 FYVE, RhoGEF and PH domain containing 2
FGD3 FYVE, RhoGEF and PH domain containing 3
FGD4 FYVE, RhoGEF and PH domain containing 4
FGD5 FYVE, RhoGEF and PH domain containing 5
FGF1 fibroblast growth factor 1 (acidic)
FLCN folliculin
FSHR follicle stimulating hormone receptor
GBA1 glucosylceramidase beta 1
GBP1 guanylate binding protein 1, interferon-inducible
GBP7 guanylate binding protein 7
GMIP GEM interacting protein
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPAT3 glycerol-3-phosphate acyltransferase 3
GPHB5 glycoprotein hormone beta 5
GRAP GRB2-related adaptor protein
GRAP2 GRB2-related adaptor protein 2
GRB2 growth factor receptor-bound protein 2
HIPK2 homeodomain interacting protein kinase 2
HSPB1 heat shock 27kDa protein 1
IL1B interleukin 1, beta
ITFG2 integrin alpha FG-GAP repeat containing 2
ITGAV integrin, alpha V
ITSN1 intersectin 1 (SH3 domain protein)
JPT2 Jupiter microtubule associated homolog 2
KALRN kalirin, RhoGEF kinase
KAT6A K(lysine) acetyltransferase 6A
KCTD11 potassium channel tetramerization domain containing 11
KDR kinase insert domain receptor
KMT5A lysine methyltransferase 5A
LRRK2 leucine-rich repeat kinase 2
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP2K6 mitogen-activated protein kinase kinase 6
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MAPT microtubule-associated protein tau
MCF2 MCF.2 cell line derived transforming sequence
MCF2L MCF.2 cell line derived transforming sequence-like
MINK1 misshapen-like kinase 1
MLF1 myeloid leukemia factor 1
MOB3B MOB kinase activator 3B
MPZ myelin protein zero
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYO9A myosin IXA
MYO9B myosin IXB
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NEK8 NIMA-related kinase 8
NF2 neurofibromin 2 (merlin)
NGEF neuronal guanine nucleotide exchange factor
NLGN1 neuroligin 1
NLRP12 NLR family, pyrin domain containing 12
NOP2 NOP2 nucleolar protein
NOP53 NOP53 ribosome biogenesis factor
NUAK1 NUAK family, SNF1-like kinase, 1
NUAK2 NUAK family, SNF1-like kinase, 2
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
OPTN optineurin
PAK1IP1 PAK1 interacting protein 1
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDPK1 3-phosphoinositide dependent protein kinase 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PGAP1 post-GPI attachment to proteins 1
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PIDD1 p53-induced death domain protein 1
PIGBOS1 PIGB opposite strand 1
PIP4P1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive)
PKN1 protein kinase N1
PKN2 protein kinase N2
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4
PLEKHG4B pleckstrin homology domain containing, family G (with RhoGef domain) member 4B
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PLK3 polo-like kinase 3
PLPP3 phospholipid phosphatase 3
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPM1K protein phosphatase, Mg2+/Mn2+ dependent, 1K
PPM1N protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRDM11 PR domain containing 11
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRMT5 protein arginine methyltransferase 5
PRPF38B pre-mRNA processing factor 38B
PTEN phosphatase and tensin homolog
PTPMT1 protein tyrosine phosphatase, mitochondrial 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PYCARD PYD and CARD domain containing
RACGAP1 Rac GTPase activating protein 1
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RCN3 reticulocalbin 3, EF-hand calcium binding domain
REPS1 RALBP1 associated Eps domain containing 1
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
RGN regucalcin
RHOD ras homolog family member D
RHOF ras homolog family member F (in filopodia)
RHOU ras homolog family member U
RICTOR RPTOR independent companion of MTOR, complex 2
RIT2 Ras-like without CAAX 2
RNF34 ring finger protein 34, E3 ubiquitin protein ligase
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
RPF2 ribosome production factor 2 homolog (S. cerevisiae)
RPL11 ribosomal protein L11
RPL5 ribosomal protein L5
RRAGB Ras-related GTP binding B
RRAGC Ras-related GTP binding C
RRAS related RAS viral (r-ras) oncogene homolog
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACK1D scaffolding CK1 anchoring protein D
SAMD5 sterile alpha motif domain containing 5
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SASH3 SAM and SH3 domain containing 3
SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
SETD9 SET domain containing 9
SGK1 serum/glucocorticoid regulated kinase 1
SGMS1 sphingomyelin synthase 1
SH3BP1 SH3-domain binding protein 1
SHOC2 soc-2 suppressor of clear homolog (C. elegans)
SIRT1 sirtuin 1
SMIM29 small integral membrane protein 29
SMYD2 SET and MYND domain containing 2
SNW1 SNW domain containing 1
SPATA13 spermatogenesis associated 13
SPHK2 sphingosine kinase 2
SPRED1 sprouty-related, EVH1 domain containing 1
SPRED2 sprouty-related, EVH1 domain containing 2
SQSTM1 sequestosome 1
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
STARD13 StAR-related lipid transfer (START) domain containing 13
STK11 serine/threonine kinase 11
STK24 serine/threonine kinase 24
STK4 serine/threonine kinase 4
STK40 serine/threonine kinase 40
STYXL1 serine/threonine/tyrosine interacting-like 1
SUMO4 small ubiquitin-like modifier 4
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYDE2 synapse defective 1, Rho GTPase, homolog 2 (C. elegans)
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TAGAP T-cell activation RhoGTPase activating protein
TAOK3 TAO kinase 3
TBCK TBC1 domain containing kinase
TEK TEK tyrosine kinase, endothelial
TIAM1 T-cell lymphoma invasion and metastasis 1
TIAM2 T-cell lymphoma invasion and metastasis 2
TMBIM4 transmembrane BAX inhibitor motif containing 4
TMEM127 transmembrane protein 127
TNF tumor necrosis factor
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNIK TRAF2 and NCK interacting kinase
TP53RK TP53 regulating kinase
TRAF1 TNF receptor-associated factor 1
TRAF3 TNF receptor-associated factor 3
TRAF4 TNF receptor-associated factor 4
TRAF5 TNF receptor-associated factor 5
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TREM2 triggering receptor expressed on myeloid cells 2
TRIM6-TRIM34 TRIM6-TRIM34 readthrough
TRIO trio Rho guanine nucleotide exchange factor
TTI1 TELO2 interacting protein 1
UBE2N ubiquitin-conjugating enzyme E2N
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1
UFL1 UFM1-specific ligase 1
ULK4 unc-51 like kinase 4
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
USP2 ubiquitin specific peptidase 2
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
VRK2 vaccinia related kinase 2
VWF von Willebrand factor
WDR54 WD repeat domain 54
WNT5A wingless-type MMTV integration site family, member 5A
WWC1 WW and C2 domain containing 1
WWC2 WW and C2 domain containing 2
WWC3 WWC family member 3
ZFAND6 zinc finger, AN1-type domain 6