| Dataset | GO Biological Process Annotations 2015 |
| Category | structural or functional annotations |
| Type | biological process |
| Description | Any heritable epigenetic process that modulates the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya. (Gene Ontology, GO_0040030) |
| External Link | http://amigo.geneontology.org/amigo/term/GO:0040030 |
| Similar Terms | |
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2 genes participating in the regulation of molecular function, epigenetic biological process from the curated GO Biological Process Annotations 2015 dataset.
