regulation of neuron apoptotic process Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons. (Gene Ontology, GO_0043523)
External Link http://amigo.geneontology.org/amigo/term/GO:0043523
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Genes

130 genes participating in the regulation of neuron apoptotic process biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ADAM8 ADAM metallopeptidase domain 8
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AKT1S1 AKT1 substrate 1 (proline-rich)
APP amyloid beta (A4) precursor protein
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough
ATF4 activating transcription factor 4
ATP13A2 ATPase type 13A2
BACE1 beta-site APP-cleaving enzyme 1
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCL2 B-cell CLL/lymphoma 2
BDNF brain-derived neurotrophic factor
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP12 caspase 12 (gene/pseudogene)
CASP14 caspase 14, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP5 caspase 5, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCL3 chemokine (C-C motif) ligand 3
CDK5 cyclin-dependent kinase 5
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CFLAR CASP8 and FADD-like apoptosis regulator
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
CLCF1 cardiotrophin-like cytokine factor 1
CLN3 ceroid-lipofuscinosis, neuronal 3
CLU clusterin
CNTF ciliary neurotrophic factor
CNTFR ciliary neurotrophic factor receptor
CPEB4 cytoplasmic polyadenylation element binding protein 4
CRLF1 cytokine receptor-like factor 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DDIT3 DNA-damage-inducible transcript 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
EGLN1 egl-9 family hypoxia-inducible factor 1
EGLN2 egl-9 family hypoxia-inducible factor 2
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
EPHA7 EPH receptor A7
ERBB3 erb-b2 receptor tyrosine kinase 3
F2R coagulation factor II (thrombin) receptor
FAIM2 Fas apoptotic inhibitory molecule 2
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FGF20 fibroblast growth factor 20
FOXB1 forkhead box B1
FOXO3 forkhead box O3
FZD9 frizzled class receptor 9
GDNF glial cell derived neurotrophic factor
GRID2 glutamate receptor, ionotropic, delta 2
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
GRM4 glutamate receptor, metabotropic 4
GRN granulin
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
HSPG2 heparan sulfate proteoglycan 2
HTRA2 HtrA serine peptidase 2
IL27RA interleukin 27 receptor, alpha
IL6ST interleukin 6 signal transducer
ISL1 ISL LIM homeobox 1
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KDM2B lysine (K)-specific demethylase 2B
KIF14 kinesin family member 14
LGMN legumain
LIG4 ligase IV, DNA, ATP-dependent
MAG myelin associated glycoprotein
MCL1 myeloid cell leukemia 1
MDK midkine (neurite growth-promoting factor 2)
MEF2C myocyte enhancer factor 2C
MSH2 mutS homolog 2
MT3 metallothionein 3
NAE1 NEDD8 activating enzyme E1 subunit 1
NAIP NLR family, apoptosis inhibitory protein
NANOS1 nanos homolog 1 (Drosophila)
NDNF neuron-derived neurotrophic factor
NF1 neurofibromin 1
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NGF nerve growth factor (beta polypeptide)
NRBP2 nuclear receptor binding protein 2
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
NTF3 neurotrophin 3
NTF4 neurotrophin 4
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
PARK7 parkinson protein 7
PCSK9 proprotein convertase subtilisin/kexin type 9
PHB1 prohibitin 1
PINK1 PTEN induced putative kinase 1
PLA2G3 phospholipase A2, group III
POU4F1 POU class 4 homeobox 1
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPT1 palmitoyl-protein thioesterase 1
PRKCG protein kinase C, gamma
PRKCI protein kinase C, iota
PRKN parkin RBR E3 ubiquitin protein ligase
PRNP prion protein
PRODH proline dehydrogenase (oxidase) 1
PTK2B protein tyrosine kinase 2 beta
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RETREG1 reticulophagy regulator 1
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
SET SET nuclear proto-oncogene
SIGMAR1 sigma non-opioid intracellular receptor 1
SIX1 SIX homeobox 1
SIX4 SIX homeobox 4
SNX6 sorting nexin 6
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SRPK2 SRSF protein kinase 2
SYNGAP1 synaptic Ras GTPase activating protein 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFB2 transforming growth factor, beta 2
TGFB3 transforming growth factor, beta 3
TMBIM1 transmembrane BAX inhibitor motif containing 1
TNF tumor necrosis factor
TOX3 TOX high mobility group box family member 3
TREM2 triggering receptor expressed on myeloid cells 2
TRIM2 tripartite motif containing 2
TYRO3 TYRO3 protein tyrosine kinase
UBB ubiquitin B
UNC5B unc-5 homolog B (C. elegans)
VEGFB vascular endothelial growth factor B
VSTM2L V-set and transmembrane domain containing 2 like
WFS1 Wolfram syndrome 1 (wolframin)