regulation of smoothened signaling pathway Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description Any process that modulates the frequency, rate or extent of smoothened signaling. (Gene Ontology, GO_0008589)
External Link http://amigo.geneontology.org/amigo/term/GO:0008589
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Genes

54 genes participating in the regulation of smoothened signaling pathway biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ACTRT1 actin-related protein T1
ARMC9 armadillo repeat containing 9
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CIBAR1 CBY1 interacting BAR domain containing 1
CREBBP CREB binding protein
DCDC2 doublecortin domain containing 2
DHH desert hedgehog
DLG5 discs, large homolog 5 (Drosophila)
EVC Ellis van Creveld protein
FBXL17 F-box and leucine-rich repeat protein 17
FGFR2 fibroblast growth factor receptor 2
FUZ fuzzy planar cell polarity protein
GAS1 growth arrest-specific 1
GAS8 growth arrest-specific 8
GLI1 GLI family zinc finger 1
GLI3 GLI family zinc finger 3
GLIS2 GLIS family zinc finger 2
GPC3 glypican 3
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HHIP hedgehog interacting protein
IFT122 intraflagellar transport 122
IFT81 intraflagellar transport 81
IHH indian hedgehog
INTU inturned planar cell polarity protein
KCTD21 potassium channel tetramerization domain containing 21
KCTD6 potassium channel tetramerization domain containing 6
KIF7 kinesin family member 7
MEGF8 multiple EGF-like-domains 8
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase
MOSMO modulator of smoothened
NCOA2 nuclear receptor coactivator 2
OTX2 orthodenticle homeobox 2
PDCL phosducin-like
PTCH1 patched 1
PTCH2 patched 2
RAB34 RAB34, member RAS oncogene family
RACK1 receptor for activated C kinase 1
RORA RAR-related orphan receptor A
SFRP1 secreted frizzled-related protein 1
SHH sonic hedgehog
STK36 serine/threonine kinase 36
SUFU suppressor of fused homolog (Drosophila)
TEDC1 tubulin epsilon and delta complex 1
TEDC2 tubulin epsilon and delta complex 2
TTC23 tetratricopeptide repeat domain 23
TUBD1 tubulin, delta 1
TULP3 tubby like protein 3
TXNDC15 thioredoxin domain containing 15
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
ULK3 unc-51 like kinase 3
VCP valosin containing protein
WDR11 WD repeat domain 11
ZIC1 Zic family member 1