rela Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description v-rel avian reticuloendotheliosis viral oncogene homolog A|NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] (NCBI Entrez Gene Database, 5970)
Similar Terms
Downloads & Tools

Genes

61 genes co-occuring with the biological term rela in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AHR aryl hydrocarbon receptor
BMP4 bone morphogenetic protein 4
BRD4 bromodomain containing 4
CD28 CD28 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHUK conserved helix-loop-helix ubiquitous kinase
CMIP c-Maf inducing protein
COMMD1 copper metabolism (Murr1) domain containing 1
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR2 chemokine (C-X-C motif) receptor 2
DPF3 D4, zinc and double PHD fingers, family 3
ERBB2 erb-b2 receptor tyrosine kinase 2
FOXP3 forkhead box P3
HPSE heparanase
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL12A interleukin 12A
IL12B interleukin 12B
IL1B interleukin 1, beta
IL23A interleukin 23, alpha subunit p19
IL2RA interleukin 2 receptor, alpha
IL6 interleukin 6
KAT2A K(lysine) acetyltransferase 2A
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12
KLF2 Kruppel-like factor 2
MAPK14 mitogen-activated protein kinase 14
MEOX2 mesenchyme homeobox 2
MIR21 microRNA 21
MIR221 microRNA 221
MIR222 microRNA 222
MMP9 matrix metallopeptidase 9
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NMRAL1 NmrA-like family domain containing 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
OXTR oxytocin receptor
PIAS3 protein inhibitor of activated STAT, 3
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PYDC2 pyrin domain containing 2
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SETD6 SET domain containing 6
SETD7 SET domain containing (lysine methyltransferase) 7
SMAD7 SMAD family member 7
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5B signal transducer and activator of transcription 5B
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TGFB1 transforming growth factor, beta 1
TNC tenascin C
TNF tumor necrosis factor
TP53 tumor protein p53
TP63 tumor protein p63
WAS Wiskott-Aldrich syndrome
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YY1 YY1 transcription factor