renal cast Gene Set
Dataset
MPO Gene-Phenotype Associations
Category
disease or phenotype associations
Type
phenotype
Description
any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts) (Mammalian Phenotype Ontology , MP_0011402 )
External Link
http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0011402
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Genes
28 gene mutations causing the renal cast phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.
Symbol
Name
ACTN4
actinin, alpha 4
APRT
adenine phosphoribosyltransferase
ARHGDIA
Rho GDP dissociation inhibitor (GDI) alpha
ASIP
agouti signaling protein
BCL2L11
BCL2-like 11 (apoptosis facilitator)
C1GALT1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
CD151
CD151 molecule (Raph blood group)
COL4A3
collagen, type IV, alpha 3 (Goodpasture antigen)
FAS
Fas cell surface death receptor
FASLG
Fas ligand (TNF superfamily, member 6)
GLIS2
GLIS family zinc finger 2
GOLM1
golgi membrane protein 1
GRM1
glutamate receptor, metabotropic 1
HMOX1
heme oxygenase 1
MYO1E
myosin IE
NOS3
nitric oxide synthase 3 (endothelial cell)
NPHS2
nephrosis 2, idiopathic, steroid-resistant (podocin)
PCCA
propionyl CoA carboxylase, alpha polypeptide
PDSS2
prenyl (decaprenyl) diphosphate synthase, subunit 2
PRDX6
peroxiredoxin 6
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RET
ret proto-oncogene
SLC7A9
solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
TLR4
toll-like receptor 4
TNS1
tensin 1
TUSC2
tumor suppressor candidate 2
UOX
urate oxidase, pseudogene
WT1
Wilms tumor 1