repaglinide-6135 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the repaglinide-6135 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADORA3 adenosine A3 receptor
AHCYL2 adenosylhomocysteinase-like 2
AMACR alpha-methylacyl-CoA racemase
ANGEL2 angel homolog 2 (Drosophila)
APOE apolipoprotein E
AREG amphiregulin
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
AVIL advillin
BCAS1 breast carcinoma amplified sequence 1
BIN1 bridging integrator 1
C1ORF68 chromosome 1 open reading frame 68
C9ORF116 chromosome 9 open reading frame 116
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CAMK1D calcium/calmodulin-dependent protein kinase ID
CAV1 caveolin 1, caveolae protein, 22kDa
CCL20 chemokine (C-C motif) ligand 20
CD163 CD163 molecule
CDC50B cell division cycle 50 P4-ATPase accessory subunit B
CFAP70 cilia and flagella associated protein 70
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
COPE coatomer protein complex, subunit epsilon
DOC2A double C2-like domains, alpha
DPEP2 dipeptidase 2
EFNA5 ephrin-A5
ELAC2 elaC ribonuclease Z 2
EPN1 epsin 1
FGD2 FYVE, RhoGEF and PH domain containing 2
FKBP5 FK506 binding protein 5
FLT3 fms-related tyrosine kinase 3
FRS2 fibroblast growth factor receptor substrate 2
FST follistatin
FSTL4 follistatin-like 4
GPATCH4 G patch domain containing 4
GRIP2 glutamate receptor interacting protein 2
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HS6ST1 heparan sulfate 6-O-sulfotransferase 1
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
HYAL1 hyaluronoglucosaminidase 1
IL11 interleukin 11
IL1R2 interleukin 1 receptor, type II
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
IZUMO4 IZUMO family member 4
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KEL Kell blood group, metallo-endopeptidase
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LZTS1 leucine zipper, putative tumor suppressor 1
MARC1 mitochondrial amidoxime reducing component 1
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MMP19 matrix metallopeptidase 19
MYCNOS MYCN opposite strand
MYH14 myosin, heavy chain 14, non-muscle
NF2 neurofibromin 2 (merlin)
OSGIN2 oxidative stress induced growth inhibitor family member 2
OSMR oncostatin M receptor
PADI1 peptidyl arginine deiminase, type I
PAIP2B poly(A) binding protein interacting protein 2B
PDLIM5 PDZ and LIM domain 5
PER1 period circadian clock 1
PGLYRP1 peptidoglycan recognition protein 1
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRB4 proline-rich protein BstNI subfamily 4
PVR poliovirus receptor
REC8 REC8 meiotic recombination protein
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SAMD4A sterile alpha motif domain containing 4A
SCIN scinderin
SDC2 syndecan 2
SERHL2 serine hydrolase-like 2
SEZ6L seizure related 6 homolog (mouse)-like
SIRPA signal-regulatory protein alpha
SIRT3 sirtuin 3
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SP1 Sp1 transcription factor
SPRR1A small proline-rich protein 1A
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SV2A synaptic vesicle glycoprotein 2A
SWAP70 SWAP switching B-cell complex 70kDa subunit
TIGD6 tigger transposable element derived 6
TMCC1 transmembrane and coiled-coil domain family 1
TSC22D3 TSC22 domain family, member 3
TTC12 tetratricopeptide repeat domain 12
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
VNN3 vanin 3
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
WTAP Wilms tumor 1 associated protein
ZBTB16 zinc finger and BTB domain containing 16
ZER1 zyg-11 related, cell cycle regulator
ZNF205 zinc finger protein 205
ZNF224 zinc finger protein 224
ZNF484 zinc finger protein 484
ZNF518A zinc finger protein 518A

decreased expression

Symbol Name
ACVR1 activin A receptor, type I
ACYP1 acylphosphatase 1, erythrocyte (common) type
AKTIP AKT interacting protein
ALG12 ALG12, alpha-1,6-mannosyltransferase
ASB7 ankyrin repeat and SOCS box containing 7
ASPN asporin
C11ORF30 chromosome 11 open reading frame 30
C16ORF59 chromosome 16 open reading frame 59
C5 complement component 5
C9ORF9 chromosome 9 open reading frame 9
CA5BP1 carbonic anhydrase VB pseudogene 1
CAPN5 calpain 5
CCL2 chemokine (C-C motif) ligand 2
CD82 CD82 molecule
CDR2L cerebellar degeneration-related protein 2-like
CEP295 centrosomal protein 295kDa
CHMP1A charged multivesicular body protein 1A
COL15A1 collagen, type XV, alpha 1
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
CRABP2 cellular retinoic acid binding protein 2
CSRNP2 cysteine-serine-rich nuclear protein 2
CTNNBIP1 catenin, beta interacting protein 1
CXCR2 chemokine (C-X-C motif) receptor 2
CYSLTR1 cysteinyl leukotriene receptor 1
DUSP8 dual specificity phosphatase 8
DYM dymeclin
ERN2 endoplasmic reticulum to nucleus signaling 2
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM13B family with sequence similarity 13, member B
FKBP14 FK506 binding protein 14, 22 kDa
GMEB1 glucocorticoid modulatory element binding protein 1
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GSTZ1 glutathione S-transferase zeta 1
GUSBP3 glucuronidase, beta pseudogene 3
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BI histone cluster 1, H2bi
HIST1H2BN histone cluster 1, H2bn
HP haptoglobin
HRH1 histamine receptor H1
HSPA4L heat shock 70kDa protein 4-like
IFT81 intraflagellar transport 81
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KDM7A lysine (K)-specific demethylase 7A
KIAA0556 KIAA0556
KIAA0754 KIAA0754
LYPLA2P1 lysophospholipase II pseudogene 1
MED9 mediator complex subunit 9
MICALL2 MICAL-like 2
MRGBP MRG/MORF4L binding protein
NDE1 nudE neurodevelopment protein 1
NSUN6 NOP2/Sun domain family, member 6
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAQR6 progestin and adipoQ receptor family member VI
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PNPLA6 patatin-like phospholipase domain containing 6
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PSKH1 protein serine kinase H1
PYGB phosphorylase, glycogen; brain
RAB33B RAB33B, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
SETD1A SET domain containing 1A
SHPK sedoheptulokinase
SIDT1 SID1 transmembrane family, member 1
SIGLEC9 sialic acid binding Ig-like lectin 9
SLC38A6 solute carrier family 38, member 6
SNX6 sorting nexin 6
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STX5 syntaxin 5
TAS2R10 taste receptor, type 2, member 10
TICAM1 toll-like receptor adaptor molecule 1
TMEM53 transmembrane protein 53
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRPS1 trichorhinophalangeal syndrome I
TTBK2 tau tubulin kinase 2
TWSG1 twisted gastrulation BMP signaling modulator 1
UPB1 ureidopropionase, beta
USP18 ubiquitin specific peptidase 18
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBTB38 zinc finger and BTB domain containing 38
ZBTB39 zinc finger and BTB domain containing 39
ZBTB48 zinc finger and BTB domain containing 48
ZDHHC18 zinc finger, DHHC-type containing 18
ZFYVE16 zinc finger, FYVE domain containing 16
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZMAT3 zinc finger, matrin-type 3
ZMAT5 zinc finger, matrin-type 5
ZNF428 zinc finger protein 428
ZNF862 zinc finger protein 862