replisome Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins. (Gene Ontology, GO_0030894)
Similar Terms
Downloads & Tools

Genes

359 proteins co-occuring with the replisome cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
TRIM21 tripartite motif containing 21 2.03434
RPA2 replication protein A2, 32kDa 2.00765
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1 1.83338
RPA1 replication protein A1, 70kDa 1.83067
RFC1 replication factor C (activator 1) 1, 145kDa 1.75659
RFC4 replication factor C (activator 1) 4, 37kDa 1.74701
RFC5 replication factor C (activator 1) 5, 36.5kDa 1.73498
RFC3 replication factor C (activator 1) 3, 38kDa 1.72619
RAD51 RAD51 recombinase 1.72244
RFC2 replication factor C (activator 1) 2, 40kDa 1.70568
PCNA proliferating cell nuclear antigen 1.70322
XPA xeroderma pigmentosum, complementation group A 1.65393
RAD52 RAD52 homolog (S. cerevisiae) 1.59778
CD4 CD4 molecule 1.59372
CHEK1 checkpoint kinase 1 1.55254
ATM ATM serine/threonine kinase 1.44742
ATR ATR serine/threonine kinase 1.39796
FEN1 flap structure-specific endonuclease 1 1.3935
ATRIP ATR interacting protein 1.3763
DNA2 DNA replication helicase/nuclease 2 1.35758
WRN Werner syndrome, RecQ helicase-like 1.33087
ZNF35 zinc finger protein 35 1.32438
RPA3 replication protein A3, 14kDa 1.29639
LIG1 ligase I, DNA, ATP-dependent 1.23505
TIPIN TIMELESS interacting protein 1.22984
PRIM1 primase, DNA, polypeptide 1 (49kDa) 1.20808
CDC45 cell division cycle 45 1.19777
ERVW-1 endogenous retrovirus group W, member 1 1.19571
EXO1 exonuclease 1 1.17671
TOP1 topoisomerase (DNA) I 1.17517
PRKDC protein kinase, DNA-activated, catalytic polypeptide 1.15364
TP53 tumor protein p53 1.14904
TROVE2 TROVE domain family, member 2 1.14853
SSB Sjogren syndrome antigen B (autoantigen La) 1.1046
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 1.08933
RECQL RecQ helicase-like 1.06751
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 1.06296
PURB purine-rich element binding protein B 1.06195
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 1.06044
CLSPN claspin 1.05842
RPA4 replication protein A4, 30kDa 1.04532
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.01883
MCM7 minichromosome maintenance complex component 7 0.992693
MCM2 minichromosome maintenance complex component 2 0.985367
WDHD1 WD repeat and HMG-box DNA binding protein 1 0.970331
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 0.969848
ERCC5 excision repair cross-complementation group 5 0.969366
MCM10 minichromosome maintenance complex component 10 0.968401
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.957352
DMWD dystrophia myotonica, WD repeat containing 0.944482
SSBP1 single-stranded DNA binding protein 1, mitochondrial 0.939269
ERCC4 excision repair cross-complementation group 4 0.920449
RAD9A RAD9 homolog A (S. pombe) 0.919046
PLAT plasminogen activator, tissue 0.912045
H2AFX H2A histone family, member X 0.912045
NABP2 nucleic acid binding protein 2 0.895794
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.887936
IL24 interleukin 24 0.886551
ERCC1 excision repair cross-complementation group 1 0.885628
RAD17 RAD17 homolog (S. pombe) 0.873186
RMI1 RecQ mediated genome instability 1 0.872266
BRCA2 breast cancer 2, early onset 0.838728
TOPBP1 topoisomerase (DNA) II binding protein 1 0.838269
MRC1 mannose receptor, C type 1 0.834138
XPC xeroderma pigmentosum, complementation group C 0.831384
TERT telomerase reverse transcriptase 0.827712
TIMELESS timeless circadian clock 0.81257
RECQL4 RecQ protein-like 4 0.791939
PAPD7 PAP associated domain containing 7 0.787359
BLM Bloom syndrome, RecQ helicase-like 0.786444
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.779126
HSPA4 heat shock 70kDa protein 4 0.765893
SP100 SP100 nuclear antigen 0.761342
HSPG2 heparan sulfate proteoglycan 2 0.747737
LIG3 ligase III, DNA, ATP-dependent 0.747285
MLH1 mutL homolog 1 0.744574
UPRT uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) 0.723472
UNG uracil-DNA glycosylase 0.71768
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) 0.709251
TICAM2 toll-like receptor adaptor molecule 2 0.700863
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.690764
RAD50 RAD50 homolog (S. cerevisiae) 0.684644
CD79A CD79a molecule, immunoglobulin-associated alpha 0.682463
ATAD5 ATPase family, AAA domain containing 5 0.682027
KRAS Kirsten rat sarcoma viral oncogene homolog 0.672026
REV1 REV1, polymerase (DNA directed) 0.665962
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.657757
CDK2 cyclin-dependent kinase 2 0.656033
RAD23B RAD23 homolog B (S. cerevisiae) 0.656033
RFWD3 ring finger and WD repeat domain 3 0.65001
MSH2 mutS homolog 2 0.639717
RAD18 RAD18 E3 ubiquitin protein ligase 0.638861
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 0.629892
POT1 protection of telomeres 1 0.628613
KLK3 kallikrein-related peptidase 3 0.628187
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 0.626909
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa 0.623504
AICDA activation-induced cytidine deaminase 0.620529
POLL polymerase (DNA directed), lambda 0.620529
GLB1 galactosidase, beta 1 0.617982
LIG4 ligase IV, DNA, ATP-dependent 0.615013
POLH polymerase (DNA directed), eta 0.607818
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 0.60655
SERTAD3 SERTA domain containing 3 0.602752
HELB helicase (DNA) B 0.602331
TOP3A topoisomerase (DNA) III alpha 0.602331
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 0.600644
CD46 CD46 molecule, complement regulatory protein 0.592232
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 0.590133
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.589714
BRCA1 breast cancer 1, early onset 0.588456
SSBP3 single stranded DNA binding protein 3 0.587199
RBPMS2 RNA binding protein with multiple splicing 2 0.585105
GP2 glycoprotein 2 (zymogen granule membrane) 0.580504
RMI2 RecQ mediated genome instability 2 0.577164
PPAN peter pan homolog (Drosophila) 0.548122
EN1 engrailed homeobox 1 0.542764
RNF4 ring finger protein 4 0.528388
CTC1 CTS telomere maintenance complex component 1 0.528388
DBF4 DBF4 zinc finger 0.52225
HUS1 HUS1 checkpoint homolog (S. pombe) 0.517756
HIAT1 hippocampus abundant transcript 1 0.5149
PSCA prostate stem cell antigen 0.513677
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.513677
SPSB4 splA/ryanodine receptor domain and SOCS box containing 4 0.508383
RNASEH1 ribonuclease H1 0.508383
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G 0.50757
PRPH peripherin 0.500258
DNAH8 dynein, axonemal, heavy chain 8 0.492966
ADH6 alcohol dehydrogenase 6 (class V) 0.483273
ATPAF1 ATP synthase mitochondrial F1 complex assembly factor 1 0.480453
ARPP21 cAMP-regulated phosphoprotein, 21kDa 0.476831
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 0.475223
MCM8 minichromosome maintenance complex component 8 0.47442
POLB polymerase (DNA directed), beta 0.470807
HLTF helicase-like transcription factor 0.469604
CD40LG CD40 ligand 0.465998
TMEM11 transmembrane protein 11 0.463997
RPAIN RPA interacting protein 0.461199
MCMBP minichromosome maintenance complex binding protein 0.460001
DEFB127 defensin, beta 127 0.454019
NPTN neuroplastin 0.450836
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.449245
FANCD2 Fanconi anemia, complementation group D2 0.446862
ZNF830 zinc finger protein 830 0.442896
CD34 CD34 molecule 0.441708
CD58 CD58 molecule 0.438146
CDC6 cell division cycle 6 0.434985
CXADR coxsackie virus and adenovirus receptor 0.434591
PIF1 PIF1 5'-to-3' DNA helicase 0.433012
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.431829
DLX5 distal-less homeobox 5 0.430647
EN2 engrailed homeobox 2 0.428678
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 0.427104
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.424353
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.423567
GPR62 G protein-coupled receptor 62 0.42082
HN1 hematological and neurological expressed 1 0.414946
CAV2 caveolin 2 0.413382
FAM134B family with sequence similarity 134, member B 0.410649
CYB5R3 cytochrome b5 reductase 3 0.409869
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.409479
NABP1 nucleic acid binding protein 1 0.404415
CREB5 cAMP responsive element binding protein 5 0.392775
IL2 interleukin 2 0.391615
GP5 glycoprotein V (platelet) 0.381969
C10ORF2 chromosome 10 open reading frame 2 0.380814
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.379276
SPO11 SPO11 meiotic protein covalently bound to DSB 0.375434
GPR75 G protein-coupled receptor 75 0.37505
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.374666
CCNG1 cyclin G1 0.374283
RPAP1 RNA polymerase II associated protein 1 0.373516
PLG plasminogen 0.369684
SLX4 SLX4 structure-specific endonuclease subunit 0.367006
HRAS Harvey rat sarcoma viral oncogene homolog 0.363949
MMS22L MMS22-like, DNA repair protein 0.361659
CDKN2A cyclin-dependent kinase inhibitor 2A 0.360133
KCTD5 potassium channel tetramerization domain containing 5 0.35899
MDC1 mediator of DNA-damage checkpoint 1 0.358228
CDC7 cell division cycle 7 0.354042
CDA cytidine deaminase 0.350622
FAM120C family with sequence similarity 120C 0.350243
TYR tyrosinase 0.349484
FAM195A family with sequence similarity 195, member A 0.344178
HOXA13 homeobox A13 0.343421
FOS FBJ murine osteosarcoma viral oncogene homolog 0.341151
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.340773
QPCT glutaminyl-peptide cyclotransferase 0.339639
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 0.337751
MSH4 mutS homolog 4 0.329461
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.323825
ISG15 ISG15 ubiquitin-like modifier 0.32195
CENPV centromere protein V 0.321575
OR13H1 olfactory receptor, family 13, subfamily H, member 1 0.321575
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 0.321201
SPAG11A sperm associated antigen 11A 0.320451
KLHL7 kelch-like family member 7 0.319702
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.319328
NOG noggin 0.315212
OR10R2 olfactory receptor, family 10, subfamily R, member 2 0.307377
XPR1 xenotropic and polytropic retrovirus receptor 1 0.307004
CECR1 cat eye syndrome chromosome region, candidate 1 0.305143
UBA7 ubiquitin-like modifier activating enzyme 7 0.304027
PVRL4 poliovirus receptor-related 4 0.304027
TONSL tonsoku-like, DNA repair protein 0.30254
CENPB centromere protein B, 80kDa 0.301425
SPAG11B sperm associated antigen 11B 0.29586
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C 0.295119
NEIL1 nei endonuclease VIII-like 1 (E. coli) 0.292157
RECQL5 RecQ protein-like 5 0.290678
CDK1 cyclin-dependent kinase 1 0.289938
SPATA22 spermatogenesis associated 22 0.285876
MLH3 mutL homolog 3 0.284769
CRLF1 cytokine receptor-like factor 1 0.282926
POLI polymerase (DNA directed) iota 0.282558
CARTPT CART prepropeptide 0.280349
TNF tumor necrosis factor 0.278509
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 0.277774
GDE1 glycerophosphodiester phosphodiesterase 1 0.276671
FLT3LG fms-related tyrosine kinase 3 ligand 0.274468
ANXA2 annexin A2 0.274101
IGHV3-30 immunoglobulin heavy variable 3-30 0.272633
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 0.270068
MMP11 matrix metallopeptidase 11 0.268237
GPANK1 G patch domain and ankyrin repeats 1 0.26385
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 0.26385
SUB1 SUB1 homolog (S. cerevisiae) 0.263485
MGME1 mitochondrial genome maintenance exonuclease 1 0.262755
TRH thyrotropin-releasing hormone 0.261296
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.258745
NUCLEOLIN nucleolin multifunctional protein 0.256197
PARP1 poly (ADP-ribose) polymerase 1 0.256197
PDGFB platelet-derived growth factor beta polypeptide 0.255107
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 0.253291
RRH retinal pigment epithelium-derived rhodopsin homolog 0.251114
BCAS2 breast carcinoma amplified sequence 2 0.250751
DHFR dihydrofolate reductase 0.250751
SGK2 serum/glucocorticoid regulated kinase 2 0.249302
HFM1 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) 0.247492
SHKBP1 SH3KBP1 binding protein 1 0.244962
RNASEH2B ribonuclease H2, subunit B 0.243158
GPR132 G protein-coupled receptor 132 0.242797
BMP4 bone morphogenetic protein 4 0.241716
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 0.239916
CD209 CD209 molecule 0.239197
LDB1 LIM domain binding 1 0.238478
HELQ helicase, POLQ-like 0.236683
PSEN2 presenilin 2 0.234533
TSPO translocator protein (18kDa) 0.234533
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.234174
TTK TTK protein kinase 0.233459
LACTB lactamase, beta 0.233101
ZNF77 zinc finger protein 77 0.232386
USP1 ubiquitin specific peptidase 1 0.229176
JMJD6 jumonji domain containing 6 0.228819
MEX3D mex-3 RNA binding family member D 0.228108
TCTA T-cell leukemia translocation altered 0.226331
JUND jun D proto-oncogene 0.225976
GINS4 GINS complex subunit 4 (Sld5 homolog) 0.224913
A2M alpha-2-macroglobulin 0.223497
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase 0.222436
PALB2 partner and localizer of BRCA2 0.221378
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 0.217861
ALPPL2 alkaline phosphatase, placental-like 2 0.217511
ALPL alkaline phosphatase, liver/bone/kidney 0.21716
ALPP alkaline phosphatase, placental 0.21681
IL17C interleukin 17C 0.21681
MRGPRD MAS-related GPR, member D 0.21646
SSBP2 single-stranded DNA binding protein 2 0.21124
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.209169
PARK2 parkin RBR E3 ubiquitin protein ligase 0.206766
FUBP3 far upstream element (FUSE) binding protein 3 0.206082
SERTAD1 SERTA domain containing 1 0.205399
AK7 adenylate kinase 7 0.204039
IFNA1 interferon, alpha 1 0.203361
SETD8 SET domain containing (lysine methyltransferase) 8 0.202346
DTYMK deoxythymidylate kinase (thymidylate kinase) 0.201672
MDK midkine (neurite growth-promoting factor 2) 0.196339
HLA-B major histocompatibility complex, class I, B 0.193719
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.19307
ICAM1 intercellular adhesion molecule 1 0.191777
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 0.18859
DDB1 damage-specific DNA binding protein 1, 127kDa 0.187333
ERCC2 excision repair cross-complementation group 2 0.186087
RTEL1 regulator of telomere elongation helicase 1 0.185469
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 0.182723
YBX1 Y box binding protein 1 0.181823
MUS81 MUS81 structure-specific endonuclease subunit 0.181524
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 0.181524
TXN thioredoxin 0.178588
BTNL2 butyrophilin-like 2 0.178588
HBE1 hemoglobin, epsilon 1 0.178011
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.177724
NANS N-acetylneuraminic acid synthase 0.177154
UIMC1 ubiquitin interaction motif containing 1 0.17687
POLM polymerase (DNA directed), mu 0.176024
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 0.174361
H2AFB1 H2A histone family, member B1 0.173273
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 0.172735
MX2 MX dynamin-like GTPase 2 0.172468
H2AFB2 H2A histone family, member B2 0.170888
NEIL2 nei endonuclease VIII-like 2 (E. coli) 0.170629
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 0.169859
KLHL12 kelch-like family member 12 0.168349
PRTN3 proteinase 3 0.168101
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.167611
TYMS thymidylate synthetase 0.167125
IFI16 interferon, gamma-inducible protein 16 0.166405
PLRG1 pleiotropic regulator 1 0.165932
ALX4 ALX homeobox 4 0.165697
ZNF24 zinc finger protein 24 0.165463
CCR3 chemokine (C-C motif) receptor 3 0.163641
HLA-C major histocompatibility complex, class I, C 0.1632
WNT9A wingless-type MMTV integration site family, member 9A 0.16233
MIR93 microRNA 93 0.16233
DBT dihydrolipoamide branched chain transacylase E2 0.161484
NTPCR nucleoside-triphosphatase, cancer-related 0.161275
CALR calreticulin 0.161068
IL10 interleukin 10 0.160863
SIRT6 sirtuin 6 0.160863
POLN polymerase (DNA directed) nu 0.160658
GCOM1 GRINL1A complex locus 1 0.160456
NBN nibrin 0.159658
HAUS3 HAUS augmin-like complex, subunit 3 0.159658
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.159462
NLRP5 NLR family, pyrin domain containing 5 0.158692
FST follistatin 0.157218
SRSF1 serine/arginine-rich splicing factor 1 0.156863
CDK7 cyclin-dependent kinase 7 0.139265
RLIM ring finger protein, LIM domain interacting 0.139222
WDR11 WD repeat domain 11 0.139179
PPP4R2 protein phosphatase 4, regulatory subunit 2 0.139091
GALK1 galactokinase 1 0.139058
TRIM24 tripartite motif containing 24 0.138913
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.13873
RPL23 ribosomal protein L23 0.138601
ATAD3C ATPase family, AAA domain containing 3C 0.138433
SYCP1 synaptonemal complex protein 1 0.138397
LCT lactase 0.138112
MSH3 mutS homolog 3 0.137998
RPAP3 RNA polymerase II associated protein 3 0.137564
C4A complement component 4A (Rodgers blood group) 0.137551
MSH6 mutS homolog 6 0.137332
SSNA1 Sjogren syndrome nuclear autoantigen 1 0.137207
ADAT2 adenosine deaminase, tRNA-specific 2 0.137207
SENP6 SUMO1/sentrin specific peptidase 6 0.137178
DSCC1 DNA replication and sister chromatid cohesion 1 0.137164
PPP1R10 protein phosphatase 1, regulatory subunit 10 0.137122
PASK PAS domain containing serine/threonine kinase 0.136979
RNF8 ring finger protein 8, E3 ubiquitin protein ligase 0.136877
RAD51D RAD51 paralog D 0.136611
RPL39 ribosomal protein L39 0.136596
RBBP8 retinoblastoma binding protein 8 0.136566
STK39 serine threonine kinase 39 0.136414
PML promyelocytic leukemia 0.136322
TPH1 tryptophan hydroxylase 1 0.136307
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 0.136307
CSN2 casein beta 0.135847