represses Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

462 genes co-occuring with the biological term represses in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
AES amino-terminal enhancer of split
AGO2 argonaute RISC catalytic component 2
AHSG alpha-2-HS-glycoprotein
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ANGPTL1 angiopoietin-like 1
ANGPTL3 angiopoietin-like 3
APP amyloid beta (A4) precursor protein
AR androgen receptor
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASXL2 additional sex combs like transcriptional regulator 2
ATF2 activating transcription factor 2
ATF3 activating transcription factor 3
ATXN3 ataxin 3
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BAMBI BMP and activin membrane-bound inhibitor
BANP BTG3 associated nuclear protein
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCR breakpoint cluster region
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
BEND3 BEN domain containing 3
BHLHE41 basic helix-loop-helix family, member e41
BIK BCL2-interacting killer (apoptosis-inducing)
BIRC5 baculoviral IAP repeat containing 5
BMI1 BMI1 proto-oncogene, polycomb ring finger
BMP7 bone morphogenetic protein 7
BP1 Blood pressure QTL 1
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BSG basigin (Ok blood group)
C11ORF30 chromosome 11 open reading frame 30
CA2 carbonic anhydrase II
CAB39 calcium binding protein 39
CALR calreticulin
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CARM1 coactivator-associated arginine methyltransferase 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBX3 chromobox homolog 3
CBX7 chromobox homolog 7
CC2D1B coiled-coil and C2 domain containing 1B
CCND1 cyclin D1
CCND3 cyclin D3
CCNG2 cyclin G2
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CDCP1 CUB domain containing protein 1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH13 cadherin 13
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN3 cyclin-dependent kinase inhibitor 3
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CELF1 CUGBP, Elav-like family member 1
CFLAR CASP8 and FADD-like apoptosis regulator
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIC capicua transcriptional repressor
CNOT1 CCR4-NOT transcription complex, subunit 1
COL2A1 collagen, type II, alpha 1
CPSF3 cleavage and polyadenylation specific factor 3, 73kDa
CREB1 cAMP responsive element binding protein 1
CREB3 cAMP responsive element binding protein 3
CREBBP CREB binding protein
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTBP1 C-terminal binding protein 1
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1
DACH1 dachshund family transcription factor 1
DAPK1 death-associated protein kinase 1
DCLK1 doublecortin-like kinase 1
DEFB1 defensin, beta 1
DEFB4A defensin, beta 4A
DLX4 distal-less homeobox 4
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DUSP1 dual specificity phosphatase 1
E2F1 E2F transcription factor 1
E2F6 E2F transcription factor 6
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EHMT2 euchromatic histone-lysine N-methyltransferase 2
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EIF5 eukaryotic translation initiation factor 5
ELAVL1 ELAV like RNA binding protein 1
ELK1 ELK1, member of ETS oncogene family
EP300 E1A binding protein p300
EP400 E1A binding protein p400
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC6 excision repair cross-complementation group 6
ERF Ets2 repressor factor
ERN2 endoplasmic reticulum to nucleus signaling 2
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETV4 ets variant 4
EYA2 EYA transcriptional coactivator and phosphatase 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM134B family with sequence similarity 134, member B
FANCA Fanconi anemia, complementation group A
FAS Fas cell surface death receptor
FBXO32 F-box protein 32
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGF19 fibroblast growth factor 19
FGF2 fibroblast growth factor 2 (basic)
FGFR1 fibroblast growth factor receptor 1
FMR1 fragile X mental retardation 1
FOXA2 forkhead box A2
FOXL2 forkhead box L2
FOXM1 forkhead box M1
FOXO3 forkhead box O3
GCSAM germinal center-associated, signaling and motility
GDF15 growth differentiation factor 15
GFI1 growth factor independent 1 transcription repressor
GLI2 GLI family zinc finger 2
GLS glutaminase
GNRHR gonadotropin-releasing hormone receptor
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GSC goosecoid homeobox
GSK3B glycogen synthase kinase 3 beta
GSTA1 glutathione S-transferase alpha 1
GSTP1 glutathione S-transferase pi 1
HAMP hepcidin antimicrobial peptide
HBB hemoglobin, beta
HBP1 HMG-box transcription factor 1
HCRT hypocretin (orexin) neuropeptide precursor
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HDAC4 histone deacetylase 4
HDAC5 histone deacetylase 5
HDAC7 histone deacetylase 7
HDAC9 histone deacetylase 9
HES1 hes family bHLH transcription factor 1
HES5 hes family bHLH transcription factor 5
HEXIM1 hexamethylene bis-acetamide inducible 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIPK2 homeodomain interacting protein kinase 2
HK2 hexokinase 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMMR hyaluronan-mediated motility receptor (RHAMM)
HMOX1 heme oxygenase 1
HNF1A HNF1 homeobox A
HNF1B HNF1 homeobox B
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HNRNPL heterogeneous nuclear ribonucleoprotein L
HOXA10 homeobox A10
HOXA11 homeobox A11
HOXD4 homeobox D4
HSF1 heat shock transcription factor 1
HTATSF1 HIV-1 Tat specific factor 1
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFNG interferon, gamma
IFRD1 interferon-related developmental regulator 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL15 interleukin 15
IL17A interleukin 17A
IL18 interleukin 18
IL1B interleukin 1, beta
IL33 interleukin 33
IL6 interleukin 6
IL7 interleukin 7
ING4 inhibitor of growth family, member 4
IRF1 interferon regulatory factor 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
IRF3 interferon regulatory factor 3
IRF8 interferon regulatory factor 8
IRS2 insulin receptor substrate 2
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JDP2 Jun dimerization protein 2
JMJD1C jumonji domain containing 1C
JUN jun proto-oncogene
JUP junction plakoglobin
KAT2A K(lysine) acetyltransferase 2A
KAT5 K(lysine) acetyltransferase 5
KDM1A lysine (K)-specific demethylase 1A
KDM2A lysine (K)-specific demethylase 2A
KDM4A lysine (K)-specific demethylase 4A
KDM5B lysine (K)-specific demethylase 5B
KLF10 Kruppel-like factor 10
KLF11 Kruppel-like factor 11
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRAS Kirsten rat sarcoma viral oncogene homolog
KSR1 kinase suppressor of ras 1
KSR2 kinase suppressor of ras 2
LATS2 large tumor suppressor kinase 2
LDLR low density lipoprotein receptor
LEF1 lymphoid enhancer-binding factor 1
LIN28A lin-28 homolog A (C. elegans)
LIN28B lin-28 homolog B (C. elegans)
LMO2 LIM domain only 2 (rhombotin-like 1)
MAF1 MAF1 homolog (S. cerevisiae)
MALT1 MALT1 paracaspase
MAML1 mastermind-like 1 (Drosophila)
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MAPT microtubule-associated protein tau
MBD2 methyl-CpG binding domain protein 2
MCPH1 microcephalin 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MECP2 methyl CpG binding protein 2
MED28 mediator complex subunit 28
MEF2A myocyte enhancer factor 2A
MIR124-1 microRNA 124-1
MIR128-1 microRNA 128-1
MIR138-1 microRNA 138-1
MIR143 microRNA 143
MIR145 microRNA 145
MIR146A microRNA 146a
MIR150 microRNA 150
MIR155 microRNA 155
MIR16-1 microRNA 16-1
MIR17HG miR-17-92 cluster host gene
MIR193B microRNA 193b
MIR196A1 microRNA 196a-1
MIR199A1 microRNA 199a-1
MIR200C microRNA 200c
MIR204 microRNA 204
MIR21 microRNA 21
MIR210 microRNA 210
MIR214 microRNA 214
MIR22 microRNA 22
MIR224 microRNA 224
MIR23A microRNA 23a
MIR302A microRNA 302a
MIR30A microRNA 30a
MIR31 microRNA 31
MIR432 microRNA 432
MIR451A microRNA 451a
MIR483 microRNA 483
MIR503 microRNA 503
MIR5787 microRNA 5787
MIR605 microRNA 605
MIR8485 microRNA 8485
MIR96 microRNA 96
MITF microphthalmia-associated transcription factor
MKL1 megakaryoblastic leukemia (translocation) 1
MMP1 matrix metallopeptidase 1
MMP13 matrix metallopeptidase 13
MMP2 matrix metallopeptidase 2
MRPL13 mitochondrial ribosomal protein L13
MST1R macrophage stimulating 1 receptor
MTA1 metastasis associated 1
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOG myogenin (myogenic factor 4)
MZF1 myeloid zinc finger 1
NANOG Nanog homeobox
NCOA3 nuclear receptor coactivator 3
NCOR1 nuclear receptor corepressor 1
NELFE negative elongation factor complex member E
NES nestin
NF1 neurofibromin 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NNMT nicotinamide N-methyltransferase
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae)
NOTCH1 notch 1
NPAS2 neuronal PAS domain protein 2
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR1I3 nuclear receptor subfamily 1, group I, member 3
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR5A1 nuclear receptor subfamily 5, group A, member 1
OVOL2 ovo-like zinc finger 2
PARP9 poly (ADP-ribose) polymerase family, member 9
PATL1 protein associated with topoisomerase II homolog 1 (yeast)
PAX3 paired box 3
PAX6 paired box 6
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDYN prodynorphin
PEBP1 phosphatidylethanolamine binding protein 1
PHB prohibitin
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
PIAS1 protein inhibitor of activated STAT, 1
PIAS2 protein inhibitor of activated STAT, 2
PIAS4 protein inhibitor of activated STAT, 4
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PKD2 polycystic kidney disease 2 (autosomal dominant)
PLK1 polo-like kinase 1
PLSCR1 phospholipid scramblase 1
PML promyelocytic leukemia
PODXL podocalyxin-like
POLR1B polymerase (RNA) I polypeptide B, 128kDa
PON1 paraoxonase 1
POU2F1 POU class 2 homeobox 1
POU2F3 POU class 2 homeobox 3
POU3F2 POU class 3 homeobox 2
POU5F1 POU class 5 homeobox 1
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PRDM1 PR domain containing 1, with ZNF domain
PRF1 perforin 1 (pore forming protein)
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCA protein kinase C, alpha
PROP1 PROP paired-like homeobox 1
PROX1 prospero homeobox 1
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTBP1 polypyrimidine tract binding protein 1
PTEN phosphatase and tensin homolog
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTH parathyroid hormone
PTK2 protein tyrosine kinase 2
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPRC protein tyrosine phosphatase, receptor type, C
PTTG1 pituitary tumor-transforming 1
RARA retinoic acid receptor, alpha
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REST RE1-silencing transcription factor
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RHOA ras homolog family member A
RHOB ras homolog family member B
RNASET2 ribonuclease T2
RNF20 ring finger protein 20, E3 ubiquitin protein ligase
RSF1 remodeling and spacing factor 1
RSPO1 R-spondin 1
RUNX1 runt-related transcription factor 1
RUNX2 runt-related transcription factor 2
RUNX3 runt-related transcription factor 3
RXRA retinoid X receptor, alpha
SAFB scaffold attachment factor B
SALL1 spalt-like transcription factor 1
SALL4 spalt-like transcription factor 4
SAP30 Sin3A-associated protein, 30kDa
SATB1 SATB homeobox 1
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SF1 splicing factor 1
SFRP1 secreted frizzled-related protein 1
SHBG sex hormone-binding globulin
SIM2 single-minded family bHLH transcription factor 2
SIRT1 sirtuin 1
SIRT4 sirtuin 4
SKI SKI proto-oncogene
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SLIT2 slit homolog 2 (Drosophila)
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMAD5 SMAD family member 5
SMC1A structural maintenance of chromosomes 1A
SNAI1 snail family zinc finger 1
SNAI2 snail family zinc finger 2
SOCS3 suppressor of cytokine signaling 3
SOX17 SRY (sex determining region Y)-box 17
SOX2 SRY (sex determining region Y)-box 2
SOX3 SRY (sex determining region Y)-box 3
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SP1 Sp1 transcription factor
SPI1 Spi-1 proto-oncogene
SPP1 secreted phosphoprotein 1
SRY sex determining region Y
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUFU suppressor of fused homolog (Drosophila)
SUMO1 small ubiquitin-like modifier 1
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TAL1 T-cell acute lymphocytic leukemia 1
TBX21 T-box 21
TBX3 T-box 3
TCEA1 transcription elongation factor A (SII), 1
TCERG1 transcription elongation regulator 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TH tyrosine hydroxylase
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TP53 tumor protein p53
TP63 tumor protein p63
TP73 tumor protein p73
TRAF3 TNF receptor-associated factor 3
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM22 tripartite motif containing 22
TRIM33 tripartite motif containing 33
TRPM3 transient receptor potential cation channel, subfamily M, member 3
UBE2I ubiquitin-conjugating enzyme E2I
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VTRNA2-1 vault RNA 2-1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
WISP2 WNT1 inducible signaling pathway protein 2
WNT1 wingless-type MMTV integration site family, member 1
XPO1 exportin 1
YBX1 Y box binding protein 1
YY1 YY1 transcription factor
ZBTB33 zinc finger and BTB domain containing 33
ZBTB38 zinc finger and BTB domain containing 38
ZBTB4 zinc finger and BTB domain containing 4
ZBTB47 zinc finger and BTB domain containing 47
ZBTB7A zinc finger and BTB domain containing 7A
ZBTB7B zinc finger and BTB domain containing 7B
ZBTB8A zinc finger and BTB domain containing 8A
ZEB1 zinc finger E-box binding homeobox 1
ZEB2 zinc finger E-box binding homeobox 2
ZNF24 zinc finger protein 24
ZNF268 zinc finger protein 268
ZNF395 zinc finger protein 395