requiring Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

147 genes co-occuring with the biological term requiring in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ACTA1 actin, alpha 1, skeletal muscle
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADRB1 adrenoceptor beta 1
AGER advanced glycosylation end product-specific receptor
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
ANGPTL2 angiopoietin-like 2
ANGPTL3 angiopoietin-like 3
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ATF6 activating transcription factor 6
ATR ATR serine/threonine kinase
ATXN3 ataxin 3
AVPR2 arginine vasopressin receptor 2
BBS2 Bardet-Biedl syndrome 2
BRAF B-Raf proto-oncogene, serine/threonine kinase
CA2 carbonic anhydrase II
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBX5 chromobox homolog 5
CCND1 cyclin D1
CCR2 chemokine (C-C motif) receptor 2
CD209 CD209 molecule
CD22 CD22 molecule
CD226 CD226 molecule
CD4 CD4 molecule
CTGF connective tissue growth factor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DACH1 dachshund family transcription factor 1
DIAPH1 diaphanous-related formin 1
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
DYNLL1 dynein, light chain, LC8-type 1
E2F1 E2F transcription factor 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EIF2A eukaryotic translation initiation factor 2A, 65kDa
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EPB41 erythrocyte membrane protein band 4.1
EPHB1 EPH receptor B1
ERCC4 excision repair cross-complementation group 4
ERN1 endoplasmic reticulum to nucleus signaling 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAS Fas cell surface death receptor
FGF23 fibroblast growth factor 23
FKRP fukutin related protein
FMO3 flavin containing monooxygenase 3
FMR1 fragile X mental retardation 1
FOXP3 forkhead box P3
FZD4 frizzled class receptor 4
FZD7 frizzled class receptor 7
GSK3B glycogen synthase kinase 3 beta
HCFC1 host cell factor C1
HDAC4 histone deacetylase 4
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HRAS Harvey rat sarcoma viral oncogene homolog
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
ICK intestinal cell (MAK-like) kinase
IFNB1 interferon, beta 1, fibroblast
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL16 interleukin 16
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL21 interleukin 21
IL24 interleukin 24
IL2RA interleukin 2 receptor, alpha
IL6 interleukin 6
IL6R interleukin 6 receptor
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KDM4C lysine (K)-specific demethylase 4C
KDR kinase insert domain receptor
KMT2A lysine (K)-specific methyltransferase 2A
LCK LCK proto-oncogene, Src family tyrosine kinase
LGALS1 lectin, galactoside-binding, soluble, 1
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MET MET proto-oncogene, receptor tyrosine kinase
MIR205 microRNA 205
MKKS McKusick-Kaufman syndrome
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYD88 myeloid differentiation primary response 88
NAMPT nicotinamide phosphoribosyltransferase
NANOG Nanog homeobox
NDRG1 N-myc downstream regulated 1
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOD1 nucleotide-binding oligomerization domain containing 1
NPC1 Niemann-Pick disease, type C1
NPC2 Niemann-Pick disease, type C2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PHF8 PHD finger protein 8
PLD1 phospholipase D1, phosphatidylcholine-specific
PNPLA3 patatin-like phospholipase domain containing 3
POU2AF1 POU class 2 associating factor 1
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRKCE protein kinase C, epsilon
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PTK2 protein tyrosine kinase 2
RAB5A RAB5A, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD50 RAD50 homolog (S. cerevisiae)
RHOA ras homolog family member A
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK2 receptor-interacting serine-threonine kinase 2
RSAD2 radical S-adenosyl methionine domain containing 2
RXRA retinoid X receptor, alpha
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SFTPB surfactant protein B
SFTPC surfactant protein C
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
STAT5B signal transducer and activator of transcription 5B
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TEK TEK tyrosine kinase, endothelial
TERF2 telomeric repeat binding factor 2
TFRC transferrin receptor
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TP53 tumor protein p53
TP73 tumor protein p73
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VKORC1 vitamin K epoxide reductase complex, subunit 1
VWF von Willebrand factor
ZBP1 Z-DNA binding protein 1