ret Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description ret proto-oncogene|This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5979)
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Genes

98 genes co-occuring with the biological term ret in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADRA2A adrenoceptor alpha 2A
ADRBK1 adrenergic, beta, receptor kinase 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALK anaplastic lymphoma receptor tyrosine kinase
ASCL1 achaete-scute family bHLH transcription factor 1
BBS2 Bardet-Biedl syndrome 2
BIRC5 baculoviral IAP repeat containing 5
BRAF B-Raf proto-oncogene, serine/threonine kinase
CA9 carbonic anhydrase IX
CCDC6 coiled-coil domain containing 6
CD44 CD44 molecule (Indian blood group)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHD4 chromodomain helicase DNA binding protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL8 chemokine (C-X-C motif) ligand 8
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK6 docking protein 6
DPYSL2 dihydropyrimidinase-like 2
EDN3 endothelin 3
EDNRB endothelin receptor type B
EGFR epidermal growth factor receptor
EPHA2 EPH receptor A2
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
FAS Fas cell surface death receptor
FLT4 fms-related tyrosine kinase 4
FRS2 fibroblast growth factor receptor substrate 2
GAB1 GRB2-associated binding protein 1
GAS1 growth arrest-specific 1
GDNF glial cell derived neurotrophic factor
GFRA1 GDNF family receptor alpha 1
GFRA2 GDNF family receptor alpha 2
GFRA4 GDNF family receptor alpha 4
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GRAP2 GRB2-related adaptor protein 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HOOK3 hook microtubule-tethering protein 3
HOXB5 homeobox B5
HRAS Harvey rat sarcoma viral oncogene homolog
IGF1R insulin-like growth factor 1 receptor
JAK2 Janus kinase 2
KAT6A K(lysine) acetyltransferase 6A
KDR kinase insert domain receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRAS Kirsten rat sarcoma viral oncogene homolog
KTN1 kinectin 1 (kinesin receptor)
LGALS1 lectin, galactoside-binding, soluble, 1
MAPK15 mitogen-activated protein kinase 15
MECP2 methyl CpG binding protein 2
MEN1 multiple endocrine neoplasia I
MET MET proto-oncogene, receptor tyrosine kinase
MKI67 marker of proliferation Ki-67
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCOA4 nuclear receptor coactivator 4
NF1 neurofibromin 1
NKX2-1 NK2 homeobox 1
NOX1 NADPH oxidase 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRG1 neuregulin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OTP orthopedia homeobox
PARK7 parkinson protein 7
PDGFB platelet-derived growth factor beta polypeptide
PHOX2B paired-like homeobox 2b
PROK1 prokineticin 1
PROKR1 prokineticin receptor 1
PROKR2 prokineticin receptor 2
PSPN persephin
PTCH1 patched 1
PTK2 protein tyrosine kinase 2
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPRJ protein tyrosine phosphatase, receptor type, J
RET ret proto-oncogene
RFPL4A ret finger protein-like 4A
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
SCN10A sodium channel, voltage gated, type X alpha subunit
SDC3 syndecan 3
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SH2B1 SH2B adaptor protein 1
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SOX10 SRY (sex determining region Y)-box 10
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STK11 serine/threonine kinase 11
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TNC tenascin C
TOP1 topoisomerase (DNA) I
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM27 tripartite motif containing 27
VEGFA vascular endothelial growth factor A
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
ZEB2 zinc finger E-box binding homeobox 2