retinal ganglion cell degeneration Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description degeneration or loss of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain (Mammalian Phenotype Ontology, MP_0008067)
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10 gene mutations causing the retinal ganglion cell degeneration phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
ASIC3 acid sensing (proton gated) ion channel 3
BCL2 B-cell CLL/lymphoma 2
FASLG Fas ligand (TNF superfamily, member 6)
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LRP5 low density lipoprotein receptor-related protein 5
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
POU4F2 POU class 4 homeobox 2
PRSS56 protease, serine, 56
TRIM2 tripartite motif containing 2