retinoblastoma Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A retinal cell cancer and malignant neoplasm of retina and neuroblastoma and neuroendocrine tumors that derives_from the tissues of the retina. (Human Disease Ontology, DOID_768)
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Genes

159 genes co-occuring with the biological term retinoblastoma in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AATF apoptosis antagonizing transcription factor
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
AKAP12 A kinase (PRKA) anchor protein 12
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
AR androgen receptor
ARF1 ADP-ribosylation factor 1
ARHGAP18 Rho GTPase activating protein 18
ATM ATM serine/threonine kinase
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BIRC5 baculoviral IAP repeat containing 5
BMP4 bone morphogenetic protein 4
BMPR1A bone morphogenetic protein receptor, type IA
BMPR1B bone morphogenetic protein receptor, type IB
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
CARM1 coactivator-associated arginine methyltransferase 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASZ1 castor zinc finger 1
CCNA1 cyclin A1
CCNA2 cyclin A2
CCND1 cyclin D1
CCNE1 cyclin E1
CCNE2 cyclin E2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD24 CD24 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK5 cyclin-dependent kinase 5
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CHEK2 checkpoint kinase 2
CHRM3 cholinergic receptor, muscarinic 3
CHRM5 cholinergic receptor, muscarinic 5
CLU clusterin
CRX cone-rod homeobox
DAPK1 death-associated protein kinase 1
DEFB4A defensin, beta 4A
DEGS1 delta(4)-desaturase, sphingolipid 1
DEK DEK proto-oncogene
E2F1 E2F transcription factor 1
E2F3 E2F transcription factor 3
EPCAM epithelial cell adhesion molecule
ERBB2 erb-b2 receptor tyrosine kinase 2
EWSR1 EWS RNA-binding protein 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F3 coagulation factor III (thromboplastin, tissue factor)
FGF7 fibroblast growth factor 7
GATA1 GATA binding protein 1 (globin transcription factor 1)
GPC6 glypican 6
GTF2I general transcription factor IIi
H2AFX H2A histone family, member X
HDAC1 histone deacetylase 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGA2 high mobility group AT-hook 2
HPSE heparanase
HRAS Harvey rat sarcoma viral oncogene homolog
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL1B interleukin 1, beta
IL6 interleukin 6
ILK integrin-linked kinase
IRS1 insulin receptor substrate 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KDM4A lysine (K)-specific demethylase 4A
KDM5A lysine (K)-specific demethylase 5A
KDM5B lysine (K)-specific demethylase 5B
KIF14 kinesin family member 14
KRT8 keratin 8, type II
LIMD1 LIM domains containing 1
LMNA lamin A/C
LRP6 low density lipoprotein receptor-related protein 6
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MGMT O-6-methylguanine-DNA methyltransferase
MIR101-1 microRNA 101-1
MIR101-2 microRNA 101-2
MIR106A microRNA 106a
MIR17 microRNA 17
MIR17HG miR-17-92 cluster host gene
MIR183 microRNA 183
MIR20A microRNA 20a
MIR21 microRNA 21
MIR215 microRNA 215
MIR376A1 microRNA 376a-1
MIR449A microRNA 449a
MIR449B microRNA 449b
MKL1 megakaryoblastic leukemia (translocation) 1
MKL2 MKL/myocardin-like 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NANOS1 nanos homolog 1 (Drosophila)
NBN nibrin
NCOR1 nuclear receptor corepressor 1
NDP Norrie disease (pseudoglioma)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NGFR nerve growth factor receptor
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOS2 nitric oxide synthase 2, inducible
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUMA1 nuclear mitotic apparatus protein 1
PAX6 paired box 6
PCAT4 prostate cancer associated transcript 4 (non-protein coding)
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLK1 polo-like kinase 1
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POU2F1 POU class 2 homeobox 1
POU3F2 POU class 3 homeobox 2
PPP1R10 protein phosphatase 1, regulatory subunit 10
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RBBP4 retinoblastoma binding protein 4
RBL1 retinoblastoma-like 1
RBL2 retinoblastoma-like 2
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RUNX2 runt-related transcription factor 2
SFRP1 secreted frizzled-related protein 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
TACR1 tachykinin receptor 1
TARDBP TAR DNA binding protein
TERT telomerase reverse transcriptase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIAM1 T-cell lymphoma invasion and metastasis 1
TMPO thymopoietin
TP53 tumor protein p53
TP73 tumor protein p73
TYMS thymidylate synthetase
UBR4 ubiquitin protein ligase E3 component n-recognin 4
VEGFA vascular endothelial growth factor A
WNT1 wingless-type MMTV integration site family, member 1
XRCC6P3 X-ray repair complementing defective repair in Chinese hamster cells 6 pseudogene 3
YY1 YY1 transcription factor