rhoc Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description ras homolog family member C|This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 389)
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Genes

47 genes co-occuring with the biological term rhoc in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ARHGAP1 Rho GTPase activating protein 1
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
BGLAP bone gamma-carboxyglutamate (gla) protein
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FMNL2 formin-like 2
FZD4 frizzled class receptor 4
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
HOPX HOP homeobox
HOXD10 homeobox D10
IL6 interleukin 6
IQGAP1 IQ motif containing GTPase activating protein 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGAV integrin, alpha V
JUN jun proto-oncogene
KISS1 KiSS-1 metastasis-suppressor
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase
LUM lumican
MAPK12 mitogen-activated protein kinase 12
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MIR10B microRNA 10b
MIR493 microRNA 493
MKI67 marker of proliferation Ki-67
MYL1 myosin, light chain 1, alkali; skeletal, fast
NOTCH1 notch 1
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PLXNB1 plexin B1
PRDX6 peroxiredoxin 6
PRKCE protein kinase C, epsilon
PTK2B protein tyrosine kinase 2 beta
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1
RHOA ras homolog family member A
RHOB ras homolog family member B
RHOC ras homolog family member C
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
S1PR2 sphingosine-1-phosphate receptor 2
SDC2 syndecan 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
WISP3 WNT1 inducible signaling pathway protein 3
ZAK sterile alpha motif and leucine zipper containing kinase AZK