rilmenidine-3133 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the rilmenidine-3133 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AFF4 AF4/FMR2 family, member 4
AGMAT agmatine ureohydrolase (agmatinase)
ALAD aminolevulinate dehydratase
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
ATP13A2 ATPase type 13A2
BPI bactericidal/permeability-increasing protein
CAPN3 calpain 3, (p94)
CD1D CD1d molecule
CD36 CD36 molecule (thrombospondin receptor)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CLEC4M C-type lectin domain family 4, member M
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
COPE coatomer protein complex, subunit epsilon
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EFNA4 ephrin-A4
EFR3B EFR3 homolog B (S. cerevisiae)
EIF5A2 eukaryotic translation initiation factor 5A2
ENDOD1 endonuclease domain containing 1
FAM49B family with sequence similarity 49, member B
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FN1 fibronectin 1
FOSL2 FOS-like antigen 2
FUBP1 far upstream element (FUSE) binding protein 1
FXYD2 FXYD domain containing ion transport regulator 2
GAL3ST4 galactose-3-O-sulfotransferase 4
GOLGA2P5 golgin A2 pseudogene 5
GPR22 G protein-coupled receptor 22
HAB1 B1 for mucin
HAP1 huntingtin-associated protein 1
HCAR3 hydroxycarboxylic acid receptor 3
HLA-F major histocompatibility complex, class I, F
HSPA2 heat shock 70kDa protein 2
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
IDUA iduronidase, alpha-L-
IFNA4 interferon, alpha 4
IL12RB1 interleukin 12 receptor, beta 1
IL27RA interleukin 27 receptor, alpha
ITPK1 inositol-tetrakisphosphate 1-kinase
IZUMO4 IZUMO family member 4
KCTD13 potassium channel tetramerization domain containing 13
MAPKAPK5-AS1 MAPKAPK5 antisense RNA 1
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
MXD4 MAX dimerization protein 4
MYO15B myosin XVB
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NBL1 neuroblastoma 1, DAN family BMP antagonist
NEURL1 neuralized E3 ubiquitin protein ligase 1
NPEPL1 aminopeptidase-like 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OLFM1 olfactomedin 1
PBRM1 polybromo 1
PCDHGA8 protocadherin gamma subfamily A, 8
PDGFB platelet-derived growth factor beta polypeptide
PER1 period circadian clock 1
PER3 period circadian clock 3
PEX26 peroxisomal biogenesis factor 26
PHLDA1 pleckstrin homology-like domain, family A, member 1
PNRC1 proline-rich nuclear receptor coactivator 1
PRMT8 protein arginine methyltransferase 8
PRR7 proline rich 7 (synaptic)
QSER1 glutamine and serine rich 1
RFTN1 raftlin, lipid raft linker 1
RGS1 regulator of G-protein signaling 1
RGS19 regulator of G-protein signaling 19
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RUNX2 runt-related transcription factor 2
SCAMP5 secretory carrier membrane protein 5
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC17A4 solute carrier family 17, member 4
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1
SLMO1 slowmo homolog 1 (Drosophila)
SOX13 SRY (sex determining region Y)-box 13
SOX4 SRY (sex determining region Y)-box 4
SPATA2L spermatogenesis associated 2-like
SPTB spectrin, beta, erythrocytic
SRR serine racemase
STAG3L4 stromal antigen 3-like 4 (pseudogene)
THBS1 thrombospondin 1
TMEM140 transmembrane protein 140
TMEM63A transmembrane protein 63A
TPCN1 two pore segment channel 1
TPMT thiopurine S-methyltransferase
TRPC2 transient receptor potential cation channel, subfamily C, member 2, pseudogene
TTC38 tetratricopeptide repeat domain 38
TYRO3 TYRO3 protein tyrosine kinase
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
ZFPL1 zinc finger protein-like 1
ZNF460 zinc finger protein 460
ZNF780B zinc finger protein 780B
ZNHIT2 zinc finger, HIT-type containing 2

decreased expression

Symbol Name
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ARRB1 arrestin, beta 1
ATG10 autophagy related 10
AXIN1 axin 1
BMP15 bone morphogenetic protein 15
C6ORF47 chromosome 6 open reading frame 47
C9ORF3 chromosome 9 open reading frame 3
CAMK4 calcium/calmodulin-dependent protein kinase IV
CBR3 carbonyl reductase 3
CCDC106 coiled-coil domain containing 106
CDHR2 cadherin-related family member 2
CHPF chondroitin polymerizing factor
CLCF1 cardiotrophin-like cytokine factor 1
CLEC3B C-type lectin domain family 3, member B
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CORT cortistatin
CTRL chymotrypsin-like
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
EDAR ectodysplasin A receptor
ELSPBP1 epididymal sperm binding protein 1
EPX eosinophil peroxidase
FAM135A family with sequence similarity 135, member A
FAM160B2 family with sequence similarity 160, member B2
FGF22 fibroblast growth factor 22
FLJ21369 uncharacterized protein FLJ21369
FLRT1 fibronectin leucine rich transmembrane protein 1
FOXO4 forkhead box O4
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GLRA1 glycine receptor, alpha 1
GPX2 glutathione peroxidase 2
GRIP2 glutamate receptor interacting protein 2
HAMP hepcidin antimicrobial peptide
HIST1H2AJ histone cluster 1, H2aj
HLA-DMB major histocompatibility complex, class II, DM beta
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
ICK intestinal cell (MAK-like) kinase
IFNA14 interferon, alpha 14
IGHMBP2 immunoglobulin mu binding protein 2
IL12B interleukin 12B
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL2 interleukin 2
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
LOC100131510 uncharacterized LOC100131510
LSP1 lymphocyte-specific protein 1
LTBP2 latent transforming growth factor beta binding protein 2
MAST3 microtubule associated serine/threonine kinase 3
MX1 MX dynamin-like GTPase 1
MYBPH myosin binding protein H
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
NACA2 nascent polypeptide-associated complex alpha subunit 2
NAG18 NAG18 mRNA
NDE1 nudE neurodevelopment protein 1
NECAB3 N-terminal EF-hand calcium binding protein 3
NPDC1 neural proliferation, differentiation and control, 1
NPFFR1 neuropeptide FF receptor 1
NXPH4 neurexophilin 4
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PCDHGA10 protocadherin gamma subfamily A, 10
PDE8B phosphodiesterase 8B
PDGFRL platelet-derived growth factor receptor-like
PIP prolactin-induced protein
PMFBP1 polyamine modulated factor 1 binding protein 1
PODNL1 podocan-like 1
POLH polymerase (DNA directed), eta
POM121L2 POM121 transmembrane nucleoporin-like 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRDM1 PR domain containing 1, with ZNF domain
PRMT7 protein arginine methyltransferase 7
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RANBP17 RAN binding protein 17
RASAL1 RAS protein activator like 1 (GAP1 like)
RCAN3 RCAN family member 3
RNF126P1 ring finger protein 126 pseudogene 1
RWDD3 RWD domain containing 3
SCN10A sodium channel, voltage gated, type X alpha subunit
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SMR3A submaxillary gland androgen regulated protein 3A
SPATA20 spermatogenesis associated 20
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
ST5 suppression of tumorigenicity 5
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TAS2R1 taste receptor, type 2, member 1
TIGD6 tigger transposable element derived 6
TMEM134 transmembrane protein 134
TRAF1 TNF receptor-associated factor 1
TTC30A tetratricopeptide repeat domain 30A
TUBA3C tubulin, alpha 3c
UBTD1 ubiquitin domain containing 1
UNKL unkempt family zinc finger-like
VEGFC vascular endothelial growth factor C
VSIG10 V-set and immunoglobulin domain containing 10
XYLT2 xylosyltransferase II
ZFHX3 zinc finger homeobox 3
ZIM2 zinc finger, imprinted 2
ZNF492 zinc finger protein 492
ZNF528 zinc finger protein 528
ZNF552 zinc finger protein 552