rilmenidine-6512 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the rilmenidine-6512 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ACACB acetyl-CoA carboxylase beta
ACAN aggrecan
ADCK4 aarF domain containing kinase 4
ADRA1A adrenoceptor alpha 1A
ADRBK1 adrenergic, beta, receptor kinase 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AMPH amphiphysin
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AQP3 aquaporin 3 (Gill blood group)
BAX BCL2-associated X protein
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BHMT2 betaine--homocysteine S-methyltransferase 2
BTF3P11 basic transcription factor 3 pseudogene 11
BTN3A3 butyrophilin, subfamily 3, member A3
C19ORF66 chromosome 19 open reading frame 66
C8ORF44 chromosome 8 open reading frame 44
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CAMK4 calcium/calmodulin-dependent protein kinase IV
CAPN9 calpain 9
CASP2 caspase 2, apoptosis-related cysteine peptidase
CC2D1A coiled-coil and C2 domain containing 1A
CCDC71 coiled-coil domain containing 71
CD52 CD52 molecule
CELA2A chymotrypsin-like elastase family, member 2A
CTNS cystinosin, lysosomal cystine transporter
CXCR6 chemokine (C-X-C motif) receptor 6
CYBB cytochrome b-245, beta polypeptide
DCC DCC netrin 1 receptor
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DST dystonin
DTNA dystrobrevin, alpha
EFS embryonal Fyn-associated substrate
EPHX2 epoxide hydrolase 2, cytoplasmic
EXOC7 exocyst complex component 7
GALR2 galanin receptor 2
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GREB1 growth regulation by estrogen in breast cancer 1
GRK5 G protein-coupled receptor kinase 5
HDAC7 histone deacetylase 7
HIRA histone cell cycle regulator
HIST1H2AL histone cluster 1, H2al
HIST1H2BC histone cluster 1, H2bc
HMOX1 heme oxygenase 1
HPR haptoglobin-related protein
ICOSLG inducible T-cell co-stimulator ligand
IGF1R insulin-like growth factor 1 receptor
IL2RG interleukin 2 receptor, gamma
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
ISG20 interferon stimulated exonuclease gene 20kDa
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KIF5A kinesin family member 5A
LY9 lymphocyte antigen 9
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K7 mitogen-activated protein kinase kinase 7
MBD1 methyl-CpG binding domain protein 1
MBD3 methyl-CpG binding domain protein 3
MST1 macrophage stimulating 1
MST1R macrophage stimulating 1 receptor
MTA1 metastasis associated 1
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NCOR2 nuclear receptor corepressor 2
NF2 neurofibromin 2 (merlin)
NPPA natriuretic peptide A
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PDLIM3 PDZ and LIM domain 3
PHF2 PHD finger protein 2
PMFBP1 polyamine modulated factor 1 binding protein 1
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PROZ protein Z, vitamin K-dependent plasma glycoprotein
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPRT protein tyrosine phosphatase, receptor type, T
RAD23B RAD23 homolog B (S. cerevisiae)
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
REM1 RAS (RAD and GEM)-like GTP-binding 1
S100A13 S100 calcium binding protein A13
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SPTBN1 spectrin, beta, non-erythrocytic 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STX7 syntaxin 7
TAPBP TAP binding protein (tapasin)
TM4SF1 transmembrane 4 L six family member 1
UPK1A uroplakin 1A
WFDC2 WAP four-disulfide core domain 2
WHSC1 Wolf-Hirschhorn syndrome candidate 1
WNK1 WNK lysine deficient protein kinase 1
WSB1 WD repeat and SOCS box containing 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZNF277 zinc finger protein 277
ZNF37BP zinc finger protein 37B, pseudogene
ZNF532 zinc finger protein 532

decreased expression

Symbol Name
ACTL8 actin-like 8
AMH anti-Mullerian hormone
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ANXA2P3 annexin A2 pseudogene 3
ARR3 arrestin 3, retinal (X-arrestin)
ATP7B ATPase, Cu++ transporting, beta polypeptide
BCORL1 BCL6 corepressor-like 1
BIRC7 baculoviral IAP repeat containing 7
BMP15 bone morphogenetic protein 15
C8ORF60 chromosome 8 open reading frame 60
CCDC9 coiled-coil domain containing 9
CD82 CD82 molecule
CGA glycoprotein hormones, alpha polypeptide
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
ELP3 elongator acetyltransferase complex subunit 3
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
FAM192A family with sequence similarity 192, member A
FBXO22 F-box protein 22
FGL1 fibrinogen-like 1
FLT4 fms-related tyrosine kinase 4
FRK fyn-related Src family tyrosine kinase
GALK1 galactokinase 1
GALT galactose-1-phosphate uridylyltransferase
GATA4 GATA binding protein 4
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPR3 G protein-coupled receptor 3
GRTP1 growth hormone regulated TBC protein 1
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HCFC2 host cell factor C2
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HOXA4 homeobox A4
HOXB2 homeobox B2
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IDI2-AS1 IDI2 antisense RNA 1
IFT54 intraflagellar transport 54
KCNK12 potassium channel, two pore domain subfamily K, member 12
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDM5C lysine (K)-specific demethylase 5C
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KIAA1456 KIAA1456
KLHL25 kelch-like family member 25
KLK5 kallikrein-related peptidase 5
KREMEN2 kringle containing transmembrane protein 2
LMTK1 lemur tail kinase 1
LOC729164 hCG1732469
LRRC61 leucine rich repeat containing 61
LYPD1 LY6/PLAUR domain containing 1
METTL16 methyltransferase like 16
MMP2 matrix metallopeptidase 2
MTSS1L metastasis suppressor 1-like
MUC3A mucin 3A, cell surface associated
MYO1E myosin IE
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NMU neuromedin U
OLFML2A olfactomedin-like 2A
PADI1 peptidyl arginine deiminase, type I
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PLEKHO2 pleckstrin homology domain containing, family O member 2
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RNF126P1 ring finger protein 126 pseudogene 1
RNF31 ring finger protein 31
RPGRIP1L RPGRIP1-like
RPP14 ribonuclease P/MRP 14kDa subunit
S100A9 S100 calcium binding protein A9
SAYSD1 SAYSVFN motif domain containing 1
SCAI suppressor of cancer cell invasion
SCGB2A2 secretoglobin, family 2A, member 2
SCN10A sodium channel, voltage gated, type X alpha subunit
SECISBP2 SECIS binding protein 2
SECTM1 secreted and transmembrane 1
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SPINK5 serine peptidase inhibitor, Kazal type 5
TAOK1 TAO kinase 1
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TDRD1 tudor domain containing 1
TET3 tet methylcytosine dioxygenase 3
TMEM180 transmembrane protein 180
TMUB2 transmembrane and ubiquitin-like domain containing 2
TPRA1 transmembrane protein, adipocyte asscociated 1
TUBG2 tubulin, gamma 2
UBQLN4 ubiquilin 4
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VIM vimentin
VLDLR very low density lipoprotein receptor
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZMYM3 zinc finger, MYM-type 3
ZNF16 zinc finger protein 16
ZNF442 zinc finger protein 442
ZNF747 zinc finger protein 747
ZNF804A zinc finger protein 804A