riluzole-3666 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the riluzole-3666 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
AAMDC adipogenesis associated, Mth938 domain containing
ACTN2 actinin, alpha 2
ADCK4 aarF domain containing kinase 4
ADGRG1 adhesion G protein-coupled receptor G1
ADRA2C adrenoceptor alpha 2C
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AHSP alpha hemoglobin stabilizing protein
AKR1C1 aldo-keto reductase family 1, member C1
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
AOAH acyloxyacyl hydrolase (neutrophil)
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APP amyloid beta (A4) precursor protein
ARHGAP28 Rho GTPase activating protein 28
B9D1 B9 protein domain 1
BMP7 bone morphogenetic protein 7
BST1 bone marrow stromal cell antigen 1
C10ORF10 chromosome 10 open reading frame 10
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CCDC57 coiled-coil domain containing 57
CD1A CD1a molecule
CD7 CD7 molecule
CDRT1 CMT1A duplicated region transcript 1
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CLDN16 claudin 16
COL7A1 collagen, type VII, alpha 1
CREBZF CREB/ATF bZIP transcription factor
CTNND2 catenin (cadherin-associated protein), delta 2
CTNS cystinosin, lysosomal cystine transporter
CTRC chymotrypsin C (caldecrin)
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7
DEFA4 defensin, alpha 4, corticostatin
DGCR5 DiGeorge syndrome critical region gene 5 (non-protein coding)
DMP1 dentin matrix acidic phosphoprotein 1
DPP4 dipeptidyl-peptidase 4
DUX1 double homeobox 1
EFCAB11 EF-hand calcium binding domain 11
EFCAB6 EF-hand calcium binding domain 6
ETV7 ets variant 7
FAM65B family with sequence similarity 65, member B
FBXO31 F-box protein 31
FKBP10 FK506 binding protein 10, 65 kDa
FOSL2 FOS-like antigen 2
GALR3 galanin receptor 3
GDAP1 ganglioside induced differentiation associated protein 1
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GSPT1 G1 to S phase transition 1
HIST1H2BM histone cluster 1, H2bm
HIST1H3F histone cluster 1, H3f
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
IRF4 interferon regulatory factor 4
ITGA7 integrin, alpha 7
IVL involucrin
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14
KIAA0319L KIAA0319-like
LMO1 LIM domain only 1 (rhombotin 1)
MED27 mediator complex subunit 27
MNMIP1 manchette microtubule inner protein 1
MPL MPL proto-oncogene, thrombopoietin receptor
MUC3B mucin 3B, cell surface associated
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYH14 myosin, heavy chain 14, non-muscle
N4BP1 NEDD4 binding protein 1
NPPB natriuretic peptide B
NPR1 natriuretic peptide receptor 1
NRP1 neuropilin 1
OGFR opioid growth factor receptor
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PALM paralemmin
PCDH7 protocadherin 7
PCDHGA10 protocadherin gamma subfamily A, 10
PDLIM4 PDZ and LIM domain 4
PDZRN3 PDZ domain containing ring finger 3
PLK4 polo-like kinase 4
PML promyelocytic leukemia
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
RAB40AL RAB40A, member RAS oncogene family-like
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RGS17 regulator of G-protein signaling 17
RHCE Rh blood group, CcEe antigens
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SOHLH2 spermatogenesis and oogenesis specific basic helix-loop-helix 2
SPATA6 spermatogenesis associated 6
SPTBN1 spectrin, beta, non-erythrocytic 1
ST18 suppression of tumorigenicity 18, zinc finger
STARD8 StAR-related lipid transfer (START) domain containing 8
T T, brachyury homolog (mouse)
TAS2R1 taste receptor, type 2, member 1
TAT tyrosine aminotransferase
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TXK TXK tyrosine kinase
UBR4 ubiquitin protein ligase E3 component n-recognin 4
XIST X inactive specific transcript (non-protein coding)
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ADAP2 ArfGAP with dual PH domains 2
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
ARHGAP22 Rho GTPase activating protein 22
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARRB2 arrestin, beta 2
ARSB arylsulfatase B
AXIN1 axin 1
BBC3 BCL2 binding component 3
C1R complement component 1, r subcomponent
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CCNJ cyclin J
CCNO cyclin O
CDK3 cyclin-dependent kinase 3
CDON cell adhesion associated, oncogene regulated
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
COBL cordon-bleu WH2 repeat protein
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DIO3 deiodinase, iodothyronine, type III
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DSCAM Down syndrome cell adhesion molecule
DUSP2 dual specificity phosphatase 2
ENOX1 ecto-NOX disulfide-thiol exchanger 1
ERN2 endoplasmic reticulum to nucleus signaling 2
EXOC6B exocyst complex component 6B
FAM102A family with sequence similarity 102, member A
FBXL7 F-box and leucine-rich repeat protein 7
FBXO46 F-box protein 46
FGF1 fibroblast growth factor 1 (acidic)
FSTL3 follistatin-like 3 (secreted glycoprotein)
GAL3ST4 galactose-3-O-sulfotransferase 4
GEMIN8 gem (nuclear organelle) associated protein 8
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPR3 G protein-coupled receptor 3
GRAMD3 GRAM domain containing 3
HIST1H1D histone cluster 1, H1d
HIST1H2AG histone cluster 1, H2ag
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IQSEC2 IQ motif and Sec7 domain 2
IRAK4 interleukin-1 receptor-associated kinase 4
IRF6 interferon regulatory factor 6
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
LAX1 lymphocyte transmembrane adaptor 1
LINS lines homolog (Drosophila)
MAK male germ cell-associated kinase
MAL mal, T-cell differentiation protein
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MBNL3 muscleblind-like splicing regulator 3
MEGF8 multiple EGF-like-domains 8
MMP9 matrix metallopeptidase 9
MOXD1 monooxygenase, DBH-like 1
MRPL44 mitochondrial ribosomal protein L44
NIPAL2 NIPA-like domain containing 2
NKX3-2 NK3 homeobox 2
NR3C2 nuclear receptor subfamily 3, group C, member 2
NT5M 5',3'-nucleotidase, mitochondrial
OLFML2A olfactomedin-like 2A
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PODXL2 podocalyxin-like 2
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RABL6 RAB, member RAS oncogene family-like 6
RNF122 ring finger protein 122
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RPA4 replication protein A4, 30kDa
SAYSD1 SAYSVFN motif domain containing 1
SCAMP5 secretory carrier membrane protein 5
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC22A14 solute carrier family 22, member 14
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC41A3 solute carrier family 41, member 3
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SLITRK5 SLIT and NTRK-like family, member 5
SMO smoothened, frizzled class receptor
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TAGLN3 transgelin 3
THBS3 thrombospondin 3
TMC7 transmembrane channel-like 7
TMEM212 transmembrane protein 212
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TRPV1 transient receptor potential cation channel, subfamily V, member 1
USB1 U6 snRNA biogenesis 1
WT1-AS WT1 antisense RNA
ZNF506 zinc finger protein 506
ZNF639 zinc finger protein 639
ZNF747 zinc finger protein 747
ZNF76 zinc finger protein 76
ZNF768 zinc finger protein 768