riluzole-7365 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the riluzole-7365 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAK1 AP2 associated kinase 1
ANKRD12 ankyrin repeat domain 12
ANKRD6 ankyrin repeat domain 6
AP1M2 adaptor-related protein complex 1, mu 2 subunit
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ARL2BP ADP-ribosylation factor-like 2 binding protein
ASF1A anti-silencing function 1A histone chaperone
ATF7IP activating transcription factor 7 interacting protein
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AURKA aurora kinase A
BTN3A2 butyrophilin, subfamily 3, member A2
C17ORF70 chromosome 17 open reading frame 70
C5 complement component 5
C9ORF156 chromosome 9 open reading frame 156
C9ORF40 chromosome 9 open reading frame 40
CA9 carbonic anhydrase IX
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCP110 centriolar coiled coil protein 110kDa
CLDN15 claudin 15
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
DCAF11 DDB1 and CUL4 associated factor 11
DENND2A DENN/MADD domain containing 2A
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EGFR epidermal growth factor receptor
EIF5B eukaryotic translation initiation factor 5B
EML3 echinoderm microtubule associated protein like 3
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ETV1 ets variant 1
EXOG endo/exonuclease (5'-3'), endonuclease G-like
EZR ezrin
FBXL7 F-box and leucine-rich repeat protein 7
FBXO11 F-box protein 11
FGF1 fibroblast growth factor 1 (acidic)
FGF13 fibroblast growth factor 13
FGFR2 fibroblast growth factor receptor 2
FKBP6 FK506 binding protein 6, 36kDa
FLOT1 flotillin 1
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GGT1 gamma-glutamyltransferase 1
GLI2 GLI family zinc finger 2
GLRB glycine receptor, beta
GLRX3 glutaredoxin 3
GRSF1 G-rich RNA sequence binding factor 1
GUK1 guanylate kinase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IER3IP1 immediate early response 3 interacting protein 1
IL17RA interleukin 17 receptor A
LIN7C lin-7 homolog C (C. elegans)
MDFIC MyoD family inhibitor domain containing
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MST1 macrophage stimulating 1
NCKAP1 NCK-associated protein 1
NDP Norrie disease (pseudoglioma)
NF2 neurofibromin 2 (merlin)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
ORAI2 ORAI calcium release-activated calcium modulator 2
PASK PAS domain containing serine/threonine kinase
PCCA propionyl CoA carboxylase, alpha polypeptide
PGK1 phosphoglycerate kinase 1
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLXNC1 plexin C1
PMCH pro-melanin-concentrating hormone
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PRRC2C proline-rich coiled-coil 2C
PTHLH parathyroid hormone-like hormone
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PVT1 Pvt1 oncogene (non-protein coding)
RAB2A RAB2A, member RAS oncogene family
RAB6A RAB6A, member RAS oncogene family
RPAIN RPA interacting protein
RPL10 ribosomal protein L10
RPL14 ribosomal protein L14
SAP30 Sin3A-associated protein, 30kDa
SCD5 stearoyl-CoA desaturase 5
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SIKE1 suppressor of IKBKE 1
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SREBF2 sterol regulatory element binding transcription factor 2
STX6 syntaxin 6
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TM6SF1 transmembrane 6 superfamily member 1
TMCO6 transmembrane and coiled-coil domains 6
TTC12 tetratricopeptide repeat domain 12
TWF1 twinfilin actin binding protein 1
TXN thioredoxin
TXNRD3 thioredoxin reductase 3
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
VDAC3 voltage-dependent anion channel 3
WSB1 WD repeat and SOCS box containing 1
ZKSCAN5 zinc finger with KRAB and SCAN domains 5
ZNF428 zinc finger protein 428

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ALPK1 alpha-kinase 1
ANKRD36 ankyrin repeat domain 36
ANXA2P1 annexin A2 pseudogene 1
APLP1 amyloid beta (A4) precursor-like protein 1
APOL6 apolipoprotein L, 6
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ASCC2 activating signal cointegrator 1 complex subunit 2
ATAD2B ATPase family, AAA domain containing 2B
BAHD1 bromo adjacent homology domain containing 1
BAK1 BCL2-antagonist/killer 1
BDNF brain-derived neurotrophic factor
BIRC3 baculoviral IAP repeat containing 3
BRAF B-Raf proto-oncogene, serine/threonine kinase
CAPN15 calpain 15
CBX4 chromobox homolog 4
CCDC106 coiled-coil domain containing 106
CCDC68 coiled-coil domain containing 68
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDH7 cadherin 7, type 2
CDON cell adhesion associated, oncogene regulated
CENPO centromere protein O
CLEC10A C-type lectin domain family 10, member A
CLEC2B C-type lectin domain family 2, member B
COG7 component of oligomeric golgi complex 7
CUEDC1 CUE domain containing 1
CXCL2 chemokine (C-X-C motif) ligand 2
DSPP dentin sialophosphoprotein
EHD3 EH-domain containing 3
ELSPBP1 epididymal sperm binding protein 1
EPN3 epsin 3
EPS8L2 EPS8-like 2
EVL Enah/Vasp-like
FAM102A family with sequence similarity 102, member A
FSD1 fibronectin type III and SPRY domain containing 1
GAB2 GRB2-associated binding protein 2
GFOD2 glucose-fructose oxidoreductase domain containing 2
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIST1H2AG histone cluster 1, H2ag
HIST1H2AI histone cluster 1, H2ai
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BJ histone cluster 1, H2bj
HIST1H3A histone cluster 1, H3a
HIST1H3B histone cluster 1, H3b
HOXC8 homeobox C8
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
JMJD4 jumonji domain containing 4
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KRT15 keratin 15, type I
KRT34 keratin 34, type I
MB myoglobin
MDFI MyoD family inhibitor
MED22 mediator complex subunit 22
MNX1 motor neuron and pancreas homeobox 1
MYBBP1A MYB binding protein (P160) 1a
MYO1D myosin ID
NABP2 nucleic acid binding protein 2
NCS1 neuronal calcium sensor 1
NDE1 nudE neurodevelopment protein 1
NECAB3 N-terminal EF-hand calcium binding protein 3
NOL6 nucleolar protein 6 (RNA-associated)
NOTCH1 notch 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB27B RAB27B, member RAS oncogene family
RAP1GAP2 RAP1 GTPase activating protein 2
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RPP25 ribonuclease P/MRP 25kDa subunit
SCEL sciellin
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC12A9 solute carrier family 12, member 9
SLC22A18 solute carrier family 22, member 18
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMAD7 SMAD family member 7
SNTA1 syntrophin, alpha 1
SPATA2L spermatogenesis associated 2-like
STARD5 StAR-related lipid transfer (START) domain containing 5
STIM1 stromal interaction molecule 1
STRN4 striatin, calmodulin binding protein 4
SYNPO synaptopodin
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAGLN transgelin
TIGD6 tigger transposable element derived 6
TLR2 toll-like receptor 2
TNS2 tensin 2
TRABD TraB domain containing
TSC22D4 TSC22 domain family, member 4
WDR91 WD repeat domain 91
ZFHX3 zinc finger homeobox 3
ZNF215 zinc finger protein 215
ZNF354A zinc finger protein 354A
ZNF480 zinc finger protein 480
ZNF580 zinc finger protein 580