rimexolone-5092 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the rimexolone-5092 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ACRV1 acrosomal vesicle protein 1
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
AGER advanced glycosylation end product-specific receptor
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALPK1 alpha-kinase 1
ANK1 ankyrin 1, erythrocytic
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOC4 apolipoprotein C-IV
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARTN artemin
ASTN1 astrotactin 1
ATP9A ATPase, class II, type 9A
C11ORF16 chromosome 11 open reading frame 16
C17ORF53 chromosome 17 open reading frame 53
CABP1 calcium binding protein 1
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CNGB3 cyclic nucleotide gated channel beta 3
COL11A2 collagen, type XI, alpha 2
COL19A1 collagen, type XIX, alpha 1
CRY2 cryptochrome circadian clock 2
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
DCX doublecortin
DMBT1 deleted in malignant brain tumors 1
DUSP1 dual specificity phosphatase 1
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ETV6 ets variant 6
FGFR2 fibroblast growth factor receptor 2
FOXO4 forkhead box O4
GLS2 glutaminase 2 (liver, mitochondrial)
GPC3 glypican 3
GRIK2 glutamate receptor, ionotropic, kainate 2
GRM4 glutamate receptor, metabotropic 4
HBB hemoglobin, beta
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOXB6 homeobox B6
HOXC11 homeobox C11
HPSE2 heparanase 2 (inactive)
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
INO80D INO80 complex subunit D
IRF5 interferon regulatory factor 5
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KIF5A kinesin family member 5A
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LRRN2 leucine rich repeat neuronal 2
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MAPT microtubule-associated protein tau
MGP matrix Gla protein
MINK1 misshapen-like kinase 1
MKL1 megakaryoblastic leukemia (translocation) 1
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MOCS1 molybdenum cofactor synthesis 1
MTMR8 myotubularin related protein 8
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic
NOTCH4 notch 4
NOVA1 neuro-oncological ventral antigen 1
NPR1 natriuretic peptide receptor 1
ONECUT2 one cut homeobox 2
PBOV1 prostate and breast cancer overexpressed 1
PDE4DIP phosphodiesterase 4D interacting protein
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PIAS4 protein inhibitor of activated STAT, 4
PKD1 polycystic kidney disease 1 (autosomal dominant)
PML promyelocytic leukemia
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PRO2964 uncharacterized protein PRO2964
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTH1R parathyroid hormone 1 receptor
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RAB11FIP3 RAB11 family interacting protein 3 (class II)
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGCC regulator of cell cycle
ROM1 retinal outer segment membrane protein 1
RUNX1 runt-related transcription factor 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SFTPD surfactant protein D
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRR2B small proline-rich protein 2B
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
THY1 Thy-1 cell surface antigen
TLX2 T-cell leukemia homeobox 2
TNS4 tensin 4
TRAC T cell receptor alpha constant
UBA6 ubiquitin-like modifier activating enzyme 6
VIPR2 vasoactive intestinal peptide receptor 2
WNT2B wingless-type MMTV integration site family, member 2B
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF223 zinc finger protein 223

decreased expression

Symbol Name
ACSL4 acyl-CoA synthetase long-chain family member 4
ANKFY1 ankyrin repeat and FYVE domain containing 1
APH1B APH1B gamma secretase subunit
ASTE1 asteroid homolog 1 (Drosophila)
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
C19ORF40 chromosome 19 open reading frame 40
CENPQ centromere protein Q
CHML choroideremia-like (Rab escort protein 2)
CNTLN centlein, centrosomal protein
COCH cochlin
CSRNP3 cysteine-serine-rich nuclear protein 3
CXCL6 chemokine (C-X-C motif) ligand 6
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DENND4A DENN/MADD domain containing 4A
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DNAL4 dynein, axonemal, light chain 4
DNMBP dynamin binding protein
DPYD dihydropyrimidine dehydrogenase
EAF2 ELL associated factor 2
ECM1 extracellular matrix protein 1
EDIL3 EGF-like repeats and discoidin I-like domains 3
EFCAB2 EF-hand calcium binding domain 2
ELAVL2 ELAV like neuron-specific RNA binding protein 2
EN2 engrailed homeobox 2
EPHB6 EPH receptor B6
ERCC2 excision repair cross-complementation group 2
ETAA1 Ewing tumor-associated antigen 1
EVPL envoplakin
FAM114A2 family with sequence similarity 114, member A2
FAM127B family with sequence similarity 127, member B
FOXC1 forkhead box C1
GAB2 GRB2-associated binding protein 2
GAREM GRB2 associated, regulator of MAPK1
GATA6 GATA binding protein 6
GID4 GID complex subunit 4
GMEB1 glucocorticoid modulatory element binding protein 1
HIRA histone cell cycle regulator
IFI6 interferon, alpha-inducible protein 6
INCENP inner centromere protein antigens 135/155kDa
IPO8 importin 8
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0556 KIAA0556
KIAA0922 KIAA0922
KIAA1462 KIAA1462
LIMS2 LIM and senescent cell antigen-like domains 2
LRP3 low density lipoprotein receptor-related protein 3
LRP5 low density lipoprotein receptor-related protein 5
LRRK1 leucine-rich repeat kinase 1
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MITF microphthalmia-associated transcription factor
MMP13 matrix metallopeptidase 13
MPP1 membrane protein, palmitoylated 1, 55kDa
MTA2 metastasis associated 1 family, member 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYL12B myosin, light chain 12B, regulatory
NBEAL2 neurobeachin-like 2
NDP Norrie disease (pseudoglioma)
NFE2L3 nuclear factor, erythroid 2-like 3
NR3C2 nuclear receptor subfamily 3, group C, member 2
NT5M 5',3'-nucleotidase, mitochondrial
PARP12 poly (ADP-ribose) polymerase family, member 12
PID1 phosphotyrosine interaction domain containing 1
PLA2G15 phospholipase A2, group XV
PLCD1 phospholipase C, delta 1
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PRKG2 protein kinase, cGMP-dependent, type II
PROSER1 proline and serine rich 1
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RAB33B RAB33B, member RAS oncogene family
RARS arginyl-tRNA synthetase
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RHOBTB2 Rho-related BTB domain containing 2
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIN1 Ras and Rab interactor 1
RPL23AP32 ribosomal protein L23a pseudogene 32
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
S100A3 S100 calcium binding protein A3
SGMS1 sphingomyelin synthase 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC35F6 solute carrier family 35, member F6
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLC46A3 solute carrier family 46, member 3
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SPIN1 spindlin 1
STEAP4 STEAP family member 4
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TASP1 taspase, threonine aspartase, 1
TENM4 teneurin transmembrane protein 4
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TRIM25 tripartite motif containing 25
WDR37 WD repeat domain 37
ZNF286A zinc finger protein 286A
ZNF408 zinc finger protein 408
ZNF813 zinc finger protein 813
ZSCAN26 zinc finger and SCAN domain containing 26