rimexolone-5517 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the rimexolone-5517 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTL8 actin-like 8
ACTR5 ARP5 actin-related protein 5 homolog (yeast)
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ANKRD6 ankyrin repeat domain 6
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
ART1 ADP-ribosyltransferase 1
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
BRD7P3 bromodomain containing 7 pseudogene 3
C11ORF63 chromosome 11 open reading frame 63
C11ORF80 chromosome 11 open reading frame 80
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CALML3 calmodulin-like 3
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CNN3 calponin 3, acidic
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CRP C-reactive protein, pentraxin-related
CST4 cystatin S
CXCL8 chemokine (C-X-C motif) ligand 8
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DEFA6 defensin, alpha 6, Paneth cell-specific
DLL3 delta-like 3 (Drosophila)
E2F4 E2F transcription factor 4, p107/p130-binding
EDRF1 erythroid differentiation regulatory factor 1
EFNB1 ephrin-B1
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
ETV4 ets variant 4
FASLG Fas ligand (TNF superfamily, member 6)
FLJ21369 uncharacterized protein FLJ21369
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPER1 G protein-coupled estrogen receptor 1
GPR85 G protein-coupled receptor 85
HAMP hepcidin antimicrobial peptide
HFE hemochromatosis
HIST1H1E histone cluster 1, H1e
HOXA9 homeobox A9
HOXB2 homeobox B2
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IFITM1 interferon induced transmembrane protein 1
IL22 interleukin 22
INPP1 inositol polyphosphate-1-phosphatase
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KEL Kell blood group, metallo-endopeptidase
KRT6B keratin 6B, type II
MAOA monoamine oxidase A
MAX MYC associated factor X
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MED25 mediator complex subunit 25
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MMP25 matrix metallopeptidase 25
MTMR7 myotubularin related protein 7
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NEURL1 neuralized E3 ubiquitin protein ligase 1
NF1 neurofibromin 1
NXF2 nuclear RNA export factor 2
PAIP2B poly(A) binding protein interacting protein 2B
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PHF7 PHD finger protein 7
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLXNB1 plexin B1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRB1 proline-rich protein BstNI subfamily 1
PRR5L proline rich 5 like
RGS5 regulator of G-protein signaling 5
RPL7 ribosomal protein L7
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPRR1A small proline-rich protein 1A
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
TAOK2 TAO kinase 2
TBCD tubulin folding cofactor D
THSD4 thrombospondin, type I, domain containing 4
TMPRSS4 transmembrane protease, serine 4
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TTC9 tetratricopeptide repeat domain 9
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UNC13A unc-13 homolog A (C. elegans)
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
UTS2 urotensin 2
VEGFB vascular endothelial growth factor B
VRTN vertebrae development associated
WIZ widely interspaced zinc finger motifs
WSCD1 WSC domain containing 1
ZC3H13 zinc finger CCCH-type containing 13
ZNF440 zinc finger protein 440
ZNF81 zinc finger protein 81
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
APH1B APH1B gamma secretase subunit
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BPGM 2,3-bisphosphoglycerate mutase
C11ORF95 chromosome 11 open reading frame 95
C22ORF29 chromosome 22 open reading frame 29
C5ORF28 chromosome 5 open reading frame 28
C8ORF33 chromosome 8 open reading frame 33
C9ORF40 chromosome 9 open reading frame 40
CAMTA1 calmodulin binding transcription activator 1
CES3 carboxylesterase 3
CFAP44 cilia and flagella associated protein 44
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
COBL cordon-bleu WH2 repeat protein
COMMD10 COMM domain containing 10
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DNMBP dynamin binding protein
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
ECI2 enoyl-CoA delta isomerase 2
ELSPBP1 epididymal sperm binding protein 1
FAM222B family with sequence similarity 222, member B
FAM53B family with sequence similarity 53, member B
FEM1C fem-1 homolog c (C. elegans)
GAA glucosidase, alpha; acid
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
HOXC10 homeobox C10
INTS9 integrator complex subunit 9
ITPKB inositol-trisphosphate 3-kinase B
KIFAP3 kinesin-associated protein 3
KPNA4 karyopherin alpha 4 (importin alpha 3)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LHX6 LIM homeobox 6
LIN7B lin-7 homolog B (C. elegans)
MCOLN3 mucolipin 3
MECR mitochondrial trans-2-enoyl-CoA reductase
METTL2B methyltransferase like 2B
MGC12488
MPI mannose phosphate isomerase
MUM1 melanoma associated antigen (mutated) 1
NCK2 NCK adaptor protein 2
NES nestin
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
ONECUT2 one cut homeobox 2
ORAI3 ORAI calcium release-activated calcium modulator 3
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PARD6A par-6 family cell polarity regulator alpha
PARP16 poly (ADP-ribose) polymerase family, member 16
PGP phosphoglycolate phosphatase
PMP22 peripheral myelin protein 22
POMZP3 POM121 and ZP3 fusion
PPT2 palmitoyl-protein thioesterase 2
PTTG3P pituitary tumor-transforming 3, pseudogene
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
PYCRL pyrroline-5-carboxylate reductase-like
RAB4B RAB4B, member RAS oncogene family
RBL1 retinoblastoma-like 1
RNF121 ring finger protein 121
RNF219 ring finger protein 219
RNF38 ring finger protein 38
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae)
SGMS1 sphingomyelin synthase 1
SH2D4A SH2 domain containing 4A
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMIM14 small integral membrane protein 14
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)
SPATS2 spermatogenesis associated, serine-rich 2
STK25 serine/threonine kinase 25
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
TARBP1 TAR (HIV-1) RNA binding protein 1
TGFBR3 transforming growth factor, beta receptor III
TMEM180 transmembrane protein 180
TMEM2 transmembrane protein 2
TMEM38B transmembrane protein 38B
TMSB15B thymosin beta 15B
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TSPYL2 TSPY-like 2
WDR19 WD repeat domain 19
WDR62 WD repeat domain 62
WWC2 WW and C2 domain containing 2
XYLT2 xylosyltransferase II
ZNF141 zinc finger protein 141
ZNF219 zinc finger protein 219
ZNF254 zinc finger protein 254
ZNF480 zinc finger protein 480
ZNF573 zinc finger protein 573
ZNF816 zinc finger protein 816
ZNF83 zinc finger protein 83
ZNHIT2 zinc finger, HIT-type containing 2