Presence of abnormal vacuoles (membrane-bound organelles) in the sarcolemma. On histological staining with hematoxylin and eosin, rimmed vacuoles are popcorn-like clear vacuoles with a densely blue rim. The vacuoles are often associated with cytoplasmic and occasionally intranuclear eosinophilic inclusions. (Human Phenotype Ontology, HP_0003805)
11 genes associated with the rimmed vacuoles phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.
