ripoptosome Gene Set

Dataset GO Cellular Component Annotations 2015
Category structural or functional annotations
Type cellular component
Description A protein complex whose core components are the receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (also called RIP1 and RIP3). Formation of the ripoptosome can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more. (Gene Ontology, GO_0097342)
External Link http://amigo.geneontology.org/amigo/term/GO:0097342
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Genes

7 proteins localized to the ripoptosome cellular component from the curated GO Cellular Component Annotations 2015 dataset.

Symbol Name
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CFLAR CASP8 and FADD-like apoptosis regulator
FADD Fas (TNFRSF6)-associated via death domain
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK3 receptor-interacting serine-threonine kinase 3
TICAM1 toll-like receptor adaptor molecule 1