risc complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation. (Gene Ontology, GO_0016442)
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Genes

120 proteins co-occuring with the risc complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
AGO2 argonaute RISC catalytic component 2 3.61737
DICER1 dicer 1, ribonuclease type III 3.29017
AGO1 argonaute RISC catalytic component 1 2.45115
DROSHA drosha, ribonuclease type III 1.89039
PIWIL1 piwi-like RNA-mediated gene silencing 1 1.83203
SND1 staphylococcal nuclease and tudor domain containing 1 1.49323
AGO3 argonaute RISC catalytic component 3 1.39239
DGCR8 DGCR8 microprocessor complex subunit 1.13983
MOV10 Mov10 RISC complex RNA helicase 1.13369
GRAMD1B GRAM domain containing 1B 1.10103
ZNF281 zinc finger protein 281 1.10103
XPO5 exportin 5 1.07714
TARBP2 TAR (HIV-1) RNA binding protein 2 1.05892
TNRC6A trinucleotide repeat containing 6A 1.05791
TSN translin 1.0418
TSNAX translin-associated factor X 1.0413
MIR17 microRNA 17 1.00202
MIR210 microRNA 210 0.99956
TRIM71 tripartite motif containing 71, E3 ubiquitin protein ligase 0.992204
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.980501
TNRC6B trinucleotide repeat containing 6B 0.928892
AGO4 argonaute RISC catalytic component 4 0.917177
TJAP1 tight junction associated protein 1 (peripheral) 0.852502
RBM4B RNA binding motif protein 4B 0.847451
LSM1 LSM1, U6 small nuclear RNA associated 0.818534
MIR21 microRNA 21 0.775928
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 0.756345
XRN1 5'-3' exoribonuclease 1 0.754076
MIR181C microRNA 181c 0.745929
EIF6 eukaryotic translation initiation factor 6 0.729732
HMP19 HMP19 protein 0.698223
DCP2 decapping mRNA 2 0.697344
TARBP1 TAR (HIV-1) RNA binding protein 1 0.683771
MTDH metadherin 0.676803
TNRC6C trinucleotide repeat containing 6C 0.672026
MIR184 microRNA 184 0.65905
GIPC2 GIPC PDZ domain containing family, member 2 0.656464
N4BP1 NEDD4 binding protein 1 0.65001
CLP1 cleavage and polyadenylation factor I subunit 1 0.635013
RBM4 RNA binding motif protein 4 0.631171
RNASEH2A ribonuclease H2, subunit A 0.609509
MRI1 methylthioribose-1-phosphate isomerase 1 0.592652
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 0.583431
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.579251
MIR185 microRNA 185 0.550186
MIR191 microRNA 191 0.533719
MIR133B microRNA 133b 0.52225
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 0.50879
GPD1L glycerol-3-phosphate dehydrogenase 1-like 0.505944
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) 0.484886
DBR1 debranching RNA lariats 1 0.48287
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.48005
TSPAN2 tetraspanin 2 0.476027
ELAVL1 ELAV like RNA binding protein 1 0.47442
CYTL1 cytokine-like 1 0.464798
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.463198
MIR107 microRNA 107 0.4608
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.459602
NKX3-1 NK3 homeobox 1 0.454019
PTBP3 polypyrimidine tract binding protein 3 0.45004
EDC4 enhancer of mRNA decapping 4 0.448848
HABP4 hyaluronan binding protein 4 0.437751
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6 0.437356
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 0.421997
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.419252
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25 0.414164
PDCD10 programmed cell death 10 0.412992
SYT11 synaptotagmin XI 0.393936
LIN28B lin-28 homolog B (C. elegans) 0.392388
MIR10B microRNA 10b 0.386208
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 0.381584
PAPD4 PAP associated domain containing 4 0.37045
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.368536
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 0.365095
SMG6 SMG6 nonsense mediated mRNA decay factor 0.363567
PABPC1 poly(A) binding protein, cytoplasmic 1 0.355183
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 0.352142
XRN2 5'-3' exoribonuclease 2 0.343799
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.332848
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 0.322325
EIF4A2 eukaryotic translation initiation factor 4A2 0.319328
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 0.304399
PARN poly(A)-specific ribonuclease 0.292157
QKI QKI, KH domain containing, RNA binding 0.292157
C6ORF25 chromosome 6 open reading frame 25 0.291417
RBM14 RNA binding motif protein 14 0.291417
FZD5 frizzled class receptor 5 0.28846
FXR1 fragile X mental retardation, autosomal homolog 1 0.285138
CCNE2 cyclin E2 0.279245
HPS4 Hermansky-Pudlak syndrome 4 0.271167
JDP2 Jun dimerization protein 2 0.253291
SOX4 SRY (sex determining region Y)-box 4 0.237042
RNMT RNA (guanine-7-) methyltransferase 0.232386
HOXA1 homeobox A1 0.229532
KHSRP KH-type splicing regulatory protein 0.227397
IL22 interleukin 22 0.214017
FKBP4 FK506 binding protein 4, 59kDa 0.206766
BIRC5 baculoviral IAP repeat containing 5 0.206423
MAPRE2 microtubule-associated protein, RP/EB family, member 2 0.202009
CNOT8 CCR4-NOT transcription complex, subunit 8 0.199659
YBX3 Y box binding protein 3 0.199325
MIR145 microRNA 145 0.19733
EOMES eomesodermin 0.196339
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.188905
PTEN phosphatase and tensin homolog 0.184241
CDC37 cell division cycle 37 0.177439
PPID peptidylprolyl isomerase D 0.176587
RECK reversion-inducing-cysteine-rich protein with kazal motifs 0.176024
EIF4E eukaryotic translation initiation factor 4E 0.174635
LATS2 large tumor suppressor kinase 2 0.174635
ATXN2 ataxin 2 0.169859
KDM6A lysine (K)-specific demethylase 6A 0.166167
DCP1A decapping mRNA 1A 0.165697
PITX1 paired-like homeodomain 1 0.163865
TOP2A topoisomerase (DNA) II alpha 170kDa 0.161905
DPYD dihydropyrimidine dehydrogenase 0.161275
SRP19 signal recognition particle 19kDa 0.161275
DDIT4 DNA-damage-inducible transcript 4 0.161275
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G 0.160053
ISCU iron-sulfur cluster assembly enzyme 0.157039