risc-loading complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A trimeric ribonucleoprotein complex that and is required for the formation of a mature RNA induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1) and TRBP (TARBP2) in association with the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. (Gene Ontology, GO_0070578)
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22 proteins co-occuring with the risc-loading complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
AGO2 argonaute RISC catalytic component 2 2.26356
DICER1 dicer 1, ribonuclease type III 1.97486
AGO1 argonaute RISC catalytic component 1 1.31358
TAAR8 trace amine associated receptor 8 1.21894
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 1.2055
PIWIL1 piwi-like RNA-mediated gene silencing 1 1.10562
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 0.916243
MOV10 Mov10 RISC complex RNA helicase 0.894868
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.841482
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 0.789649
MRI1 methylthioribose-1-phosphate isomerase 1 0.772275
XPO5 exportin 5 0.684207
CDC37 cell division cycle 37 0.659913
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.595593
GPR176 G protein-coupled receptor 176 0.534951
TP63 tumor protein p63 0.506757
C6ORF25 chromosome 6 open reading frame 25 0.448848
FKBP4 FK506 binding protein 4, 59kDa 0.386979
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.30626
CDK9 cyclin-dependent kinase 9 0.196669
ADA adenosine deaminase 0.183328
HSPA8 heat shock 70kDa protein 8 0.165932