| Dataset | GO Cellular Component Annotations 2015 |
| Category | structural or functional annotations |
| Type | cellular component |
| Description | A trimeric ribonucleoprotein complex that and is required for the formation of a mature RNA induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1) and TRBP (TARBP2) in association with the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. (Gene Ontology, GO_0070578) |
| External Link | http://amigo.geneontology.org/amigo/term/GO:0070578 |
| Similar Terms | |
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6 proteins localized to the risc-loading complex cellular component from the curated GO Cellular Component Annotations 2015 dataset.
