rnf8 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description ring finger protein 8, E3 ubiquitin protein ligase|The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] (NCBI Entrez Gene Database, 9025)
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Genes

23 genes co-occuring with the biological term rnf8 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
BRCA1 breast cancer 1, early onset
C1ORF86 chromosome 1 open reading frame 86
FANCD2 Fanconi anemia, complementation group D2
H2AFX H2A histone family, member X
HIST2H2AA3 histone cluster 2, H2aa3
MDC1 mediator of DNA-damage checkpoint 1
NBN nibrin
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PALB2 partner and localizer of BRCA2
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RPSA ribosomal protein SA
RXRA retinoid X receptor, alpha
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TP53BP1 tumor protein p53 binding protein 1
UBE2N ubiquitin-conjugating enzyme E2N
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2
UIMC1 ubiquitin interaction motif containing 1
USP17L2 ubiquitin specific peptidase 17-like family member 2
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)