rolitetracycline-5331 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the rolitetracycline-5331 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ACVR2B activin A receptor, type IIB
ADCY1 adenylate cyclase 1 (brain)
ADCY6 adenylate cyclase 6
AK1 adenylate kinase 1
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
BAIAP2 BAI1-associated protein 2
BAIAP3 BAI1-associated protein 3
C22ORF46 chromosome 22 open reading frame 46
CASP8 caspase 8, apoptosis-related cysteine peptidase
CC2D1A coiled-coil and C2 domain containing 1A
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CEP152 centrosomal protein 152kDa
CERK ceramide kinase
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
DCTN1 dynactin 1
DOK4 docking protein 4
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FER fer (fps/fes related) tyrosine kinase
FH fumarate hydratase
GAP43 growth associated protein 43
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GPX2 glutathione peroxidase 2
GSTM1 glutathione S-transferase mu 1
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HPS1 Hermansky-Pudlak syndrome 1
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
IFT27 intraflagellar transport 27
IRF1 interferon regulatory factor 1
JAK3 Janus kinase 3
KDM4B lysine (K)-specific demethylase 4B
KIF3C kinesin family member 3C
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
LAMC2 laminin, gamma 2
LMNA lamin A/C
LRRC20 leucine rich repeat containing 20
LRRC37BP1 leucine rich repeat containing 37B pseudogene 1
LYRM9 LYR motif containing 9
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAP4 microtubule-associated protein 4
MAPK13 mitogen-activated protein kinase 13
MARK4 MAP/microtubule affinity-regulating kinase 4
MAST3 microtubule associated serine/threonine kinase 3
MAST4 microtubule associated serine/threonine kinase family member 4
MECP2 methyl CpG binding protein 2
METTL7A methyltransferase like 7A
MPPE1 metallophosphoesterase 1
MSL3 male-specific lethal 3 homolog (Drosophila)
MZF1 myeloid zinc finger 1
NF1 neurofibromin 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NMT1 N-myristoyltransferase 1
NR2E3 nuclear receptor subfamily 2, group E, member 3
NR2F6 nuclear receptor subfamily 2, group F, member 6
NRF1 nuclear respiratory factor 1
ONECUT2 one cut homeobox 2
PCDHB3 protocadherin beta 3
PDCD6 programmed cell death 6
PDE3B phosphodiesterase 3B, cGMP-inhibited
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PNMAL1 paraneoplastic Ma antigen family-like 1
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
QKI QKI, KH domain containing, RNA binding
RGS12 regulator of G-protein signaling 12
RPH3A rabphilin 3A
SFXN3 sideroflexin 3
SH2D3A SH2 domain containing 3A
SH3BP2 SH3-domain binding protein 2
SIGLEC6 sialic acid binding Ig-like lectin 6
SIK1 salt-inducible kinase 1
SIVA1 SIVA1, apoptosis-inducing factor
SLC12A8 solute carrier family 12, member 8
SLC48A1 solute carrier family 48 (heme transporter), member 1
SMC1A structural maintenance of chromosomes 1A
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SOCS1 suppressor of cytokine signaling 1
STIM1 stromal interaction molecule 1
STK11 serine/threonine kinase 11
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TK2 thymidine kinase 2, mitochondrial
TMEM104 transmembrane protein 104
TMEM120B transmembrane protein 120B
UBOX5 U-box domain containing 5
USP20 ubiquitin specific peptidase 20
VAV2 vav 2 guanine nucleotide exchange factor
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
ZNF276 zinc finger protein 276
ZNF592 zinc finger protein 592
ZNF747 zinc finger protein 747
ZNF821 zinc finger protein 821

decreased expression

Symbol Name
AAR2 AAR2 splicing factor homolog (S. cerevisiae)
ABHD14A abhydrolase domain containing 14A
ABLIM3 actin binding LIM protein family, member 3
ADGRE5 adhesion G protein-coupled receptor E5
AEN apoptosis enhancing nuclease
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ARRB2 arrestin, beta 2
ATG4A autophagy related 4A, cysteine peptidase
C16ORF59 chromosome 16 open reading frame 59
C16ORF62 chromosome 16 open reading frame 62
CEP72 centrosomal protein 72kDa
CHML choroideremia-like (Rab escort protein 2)
CLDN15 claudin 15
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
DET1 de-etiolated homolog 1 (Arabidopsis)
DHRS1 dehydrogenase/reductase (SDR family) member 1
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7
DNM1 dynamin 1
DPF2 D4, zinc and double PHD fingers family 2
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
ECHDC3 enoyl CoA hydratase domain containing 3
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EFHD2 EF-hand domain family, member D2
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ERO1L ERO1-like (S. cerevisiae)
FAM160B2 family with sequence similarity 160, member B2
FBXO3 F-box protein 3
FKBP2 FK506 binding protein 2, 13kDa
FOXJ2 forkhead box J2
FOXM1 forkhead box M1
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
GAREM GRB2 associated, regulator of MAPK1
GLCE glucuronic acid epimerase
GMIP GEM interacting protein
GYS1 glycogen synthase 1 (muscle)
HHLA3 HERV-H LTR-associating 3
HIRA histone cell cycle regulator
HIST1H2BI histone cluster 1, H2bi
HIST2H2AA3 histone cluster 2, H2aa3
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
KIF18A kinesin family member 18A
KNTC1 kinetochore associated 1
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LMNB1 lamin B1
LOXL1 lysyl oxidase-like 1
MED24 mediator complex subunit 24
MRPL52 mitochondrial ribosomal protein L52
MTG1 mitochondrial ribosome-associated GTPase 1
MXRA7 matrix-remodelling associated 7
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
NAP1L4 nucleosome assembly protein 1-like 4
NDEL1 nudE neurodevelopment protein 1-like 1
NPM3 nucleophosmin/nucleoplasmin 3
NRBF2 nuclear receptor binding factor 2
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
ORC1 origin recognition complex, subunit 1
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PILRB paired immunoglobin-like type 2 receptor beta
PISD phosphatidylserine decarboxylase
PKN1 protein kinase N1
PODXL podocalyxin-like
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PRR7 proline rich 7 (synaptic)
PSPC1 paraspeckle component 1
RAB33B RAB33B, member RAS oncogene family
RNF121 ring finger protein 121
RNF146 ring finger protein 146
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRP1 ribosomal RNA processing 1
SCML2 sex comb on midleg-like 2 (Drosophila)
SETD8 SET domain containing (lysine methyltransferase) 8
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SKA1 spindle and kinetochore associated complex subunit 1
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC22A18 solute carrier family 22, member 18
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SQRDL sulfide quinone reductase-like (yeast)
STAG3 stromal antigen 3
SYNGR3 synaptogyrin 3
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TESK1 testis-specific kinase 1
TMEM115 transmembrane protein 115
TMEM184C transmembrane protein 184C
TMEM57 transmembrane protein 57
TMSB15A thymosin beta 15a
TOLLIP toll interacting protein
TRABD TraB domain containing
TRIP10 thyroid hormone receptor interactor 10
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TTF2 transcription termination factor, RNA polymerase II
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1
URGCP upregulator of cell proliferation
VAV1 vav 1 guanine nucleotide exchange factor
XKR8 XK, Kell blood group complex subunit-related family, member 8
ZNF408 zinc finger protein 408
ZNF668 zinc finger protein 668
ZSCAN9 zinc finger and SCAN domain containing 9