rotenone-5920 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the rotenone-5920 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM22 ADAM metallopeptidase domain 22
AGMAT agmatine ureohydrolase (agmatinase)
AIM1L absent in melanoma 1-like
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDOB aldolase B, fructose-bisphosphate
ALPK3 alpha-kinase 3
APOLD1 apolipoprotein L domain containing 1
ARTN artemin
ATP9B ATPase, class II, type 9B
BCL6 B-cell CLL/lymphoma 6
BGN biglycan
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C10ORF10 chromosome 10 open reading frame 10
C5ORF45 chromosome 5 open reading frame 45
CACYBP calcyclin binding protein
CDC14A cell division cycle 14A
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
CNOT8 CCR4-NOT transcription complex, subunit 8
CNTD2 cyclin N-terminal domain containing 2
CSF1R colony stimulating factor 1 receptor
CT55 cancer/testis antigen 55
CXCR4 chemokine (C-X-C motif) receptor 4
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DCAF15 DDB1 and CUL4 associated factor 15
DKFZP434C153 DKFZP434C153 protein
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
EN2 engrailed homeobox 2
EPB41L1 erythrocyte membrane protein band 4.1-like 1
FBLN1 fibulin 1
FGL2 fibrinogen-like 2
FKBP10 FK506 binding protein 10, 65 kDa
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GAN gigaxonin
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPR85 G protein-coupled receptor 85
GSK3A glycogen synthase kinase 3 alpha
GYG2 glycogenin 2
HABP4 hyaluronan binding protein 4
HAPLN1 hyaluronan and proteoglycan link protein 1
HEATR6 HEAT repeat containing 6
HIC2 hypermethylated in cancer 2
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
ICOSLG inducible T-cell co-stimulator ligand
IFNAR1 interferon (alpha, beta and omega) receptor 1
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
LOC100287590 uncharacterized LOC100287590
LRP4 low density lipoprotein receptor-related protein 4
LRRK1 leucine-rich repeat kinase 1
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAGEF1 melanoma antigen family F1
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MFAP3L microfibrillar-associated protein 3-like
MORN1 MORN repeat containing 1
MRC2 mannose receptor, C type 2
NOX1 NADPH oxidase 1
NPAS3 neuronal PAS domain protein 3
NPC1 Niemann-Pick disease, type C1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDH7 protocadherin 7
PDE4DIP phosphodiesterase 4D interacting protein
PIP prolactin-induced protein
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLXNB3 plexin B3
PRB3 proline-rich protein BstNI subfamily 3
PRM1 protamine 1
PTPRR protein tyrosine phosphatase, receptor type, R
QSER1 glutamine and serine rich 1
RAD50 RAD50 homolog (S. cerevisiae)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RETN resistin
RGS4 regulator of G-protein signaling 4
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RPS3A ribosomal protein S3A
SENP6 SUMO1/sentrin specific peptidase 6
SGK2 serum/glucocorticoid regulated kinase 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLN sarcolipin
SOGA1 suppressor of glucose, autophagy associated 1
SOS2 son of sevenless homolog 2 (Drosophila)
SSH3 slingshot protein phosphatase 3
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
STC1 stanniocalcin 1
STOML1 stomatin (EPB72)-like 1
SYNGR3 synaptogyrin 3
TCEAL2 transcription elongation factor A (SII)-like 2
TRIM14 tripartite motif containing 14
TRIM25 tripartite motif containing 25
TSC22D2 TSC22 domain family, member 2
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
ULK2 unc-51 like autophagy activating kinase 2
UNC45A unc-45 homolog A (C. elegans)
VIPR1 vasoactive intestinal peptide receptor 1
ZFP64 ZFP64 zinc finger protein
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
AGBL3 ATP/GTP binding protein-like 3
AK5 adenylate kinase 5
AP4M1 adaptor-related protein complex 4, mu 1 subunit
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
APOL6 apolipoprotein L, 6
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARID5A AT rich interactive domain 5A (MRF1-like)
ASIC3 acid sensing (proton gated) ion channel 3
ATAT1 alpha tubulin acetyltransferase 1
ATG10 autophagy related 10
BAAT bile acid CoA:amino acid N-acyltransferase
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
BTF3P11 basic transcription factor 3 pseudogene 11
C17ORF80 chromosome 17 open reading frame 80
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C22ORF46 chromosome 22 open reading frame 46
C5ORF42 chromosome 5 open reading frame 42
C8ORF44 chromosome 8 open reading frame 44
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CDKL3 cyclin-dependent kinase-like 3
CISH cytokine inducible SH2-containing protein
CLCN2 chloride channel, voltage-sensitive 2
CLDN8 claudin 8
CRLF1 cytokine receptor-like factor 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
DES desmin
DOC2A double C2-like domains, alpha
DOCK3 dedicator of cytokinesis 3
ECM1 extracellular matrix protein 1
EXD3 exonuclease 3'-5' domain containing 3
EXO5 exonuclease 5
FAM50B family with sequence similarity 50, member B
GDF5 growth differentiation factor 5
GEMIN8 gem (nuclear organelle) associated protein 8
GJA8 gap junction protein, alpha 8, 50kDa
GPR68 G protein-coupled receptor 68
GRTP1 growth hormone regulated TBC protein 1
HIST1H2AI histone cluster 1, H2ai
HIST1H3G histone cluster 1, H3g
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HPS5 Hermansky-Pudlak syndrome 5
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IL17RB interleukin 17 receptor B
IL32 interleukin 32
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KCTD20 potassium channel tetramerization domain containing 20
KERA keratocan
KL klotho
KLF3 Kruppel-like factor 3 (basic)
LRRC75B leucine rich repeat containing 75B
MAGEA10 melanoma antigen family A10
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MCTP1 multiple C2 domains, transmembrane 1
MRPL41 mitochondrial ribosomal protein L41
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MX1 MX dynamin-like GTPase 1
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NDNF neuron-derived neurotrophic factor
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PTCH2 patched 2
RNF39 ring finger protein 39
S100A3 S100 calcium binding protein A3
S100B S100 calcium binding protein B
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SDC3 syndecan 3
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
SETD8 SET domain containing (lysine methyltransferase) 8
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLMO1 slowmo homolog 1 (Drosophila)
SNRPN small nuclear ribonucleoprotein polypeptide N
SOX30 SRY (sex determining region Y)-box 30
SPATA2L spermatogenesis associated 2-like
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
STK32B serine/threonine kinase 32B
SYNGR4 synaptogyrin 4
TCP10L t-complex 10-like
TMEM180 transmembrane protein 180
TMEM212 transmembrane protein 212
TNN tenascin N
TSPAN2 tetraspanin 2
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
USP20 ubiquitin specific peptidase 20
VGF VGF nerve growth factor inducible
XYLT2 xylosyltransferase II
ZFP30 ZFP30 zinc finger protein
ZNF197 zinc finger protein 197
ZNF222 zinc finger protein 222
ZNF234 zinc finger protein 234
ZNF37BP zinc finger protein 37B, pseudogene
ZNF385D zinc finger protein 385D
ZNF428 zinc finger protein 428
ZNF667 zinc finger protein 667