rottlerin Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A chromenol that is 2,2-dimethyl-2H-chromene substituted by hydroxy groups at positions 5 and 7, a 3-acetyl-2,4,6-trihydroxy-5-methylbenzyl group at position 6 and a (1E)-3-oxo-1-phenylprop-1-en-3-yl group at position 8. A potassium channel opener, it is isolated from Mallotus philippensis. (Chemical Entities of Biological Interest Ontology, CHEBI_8899)
External Link http://ctdbase.org/detail.go?type=chem&acc=C085746
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Genes

82 genes/proteins interacting with the chemical rottlerin from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKT1 v-akt murine thymoma viral oncogene homolog 1
APP amyloid beta (A4) precursor protein
ATG7 autophagy related 7
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BECN1 beclin 1, autophagy related
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CCND3 cyclin D3
CD38 CD38 molecule
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
COL1A1 collagen, type I, alpha 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
EEF2 eukaryotic translation elongation factor 2
EGFR epidermal growth factor receptor
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELAVL1 ELAV like RNA binding protein 1
FGF1 fibroblast growth factor 1 (acidic)
FGF2 fibroblast growth factor 2 (basic)
FOS FBJ murine osteosarcoma viral oncogene homolog
GCLC glutamate-cysteine ligase, catalytic subunit
GDF15 growth differentiation factor 15
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
HMOX1 heme oxygenase 1
HNRNPK heterogeneous nuclear ribonucleoprotein K
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IFNA2 interferon, alpha 2
IL12B interleukin 12B
IL2 interleukin 2
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
LDLR low density lipoprotein receptor
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MARCKS myristoylated alanine-rich protein kinase C substrate
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MMP2 matrix metallopeptidase 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NCF2 neutrophil cytosolic factor 2
NFE2L2 nuclear factor, erythroid 2-like 2
NOX1 NADPH oxidase 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NTS neurotensin
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PARP1 poly (ADP-ribose) polymerase 1
PLD1 phospholipase D1, phosphatidylcholine-specific
PLSCR1 phospholipid scramblase 1
PPARG peroxisome proliferator-activated receptor gamma
PRDX1 peroxiredoxin 1
PRKCD protein kinase C, delta
PRKCQ protein kinase C, theta
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RB1 retinoblastoma 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RUNX2 runt-related transcription factor 2
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SOD2 superoxide dismutase 2, mitochondrial
STS steroid sulfatase (microsomal), isozyme S
TGFA transforming growth factor, alpha
TH tyrosine hydroxylase
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TYR tyrosinase
VEGFA vascular endothelial growth factor A
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase