ruffle Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. (Gene Ontology, GO_0001726)
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Genes

125 proteins localized to the ruffle cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
SH3YL1 SH3 and SYLF domain containing 1 0.663342
MACF1 microtubule-actin crosslinking factor 1 0.663342
NME1-NME2 NME1-NME2 readthrough 0.663342
NME1 NME/NM23 nucleoside diphosphate kinase 1 0.663342
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.663342
NF2 neurofibromin 2 (merlin) 0.663342
SNX9 sorting nexin 9 0.663342
PPP1R9B protein phosphatase 1, regulatory subunit 9B 0.663342
PLCG1 phospholipase C, gamma 1 0.663342
ADGRE2 adhesion G protein-coupled receptor E2 0.663342
SNX5 sorting nexin 5 0.663342
C2CD5 C2 calcium-dependent domain containing 5 0.663342
CLASP2 cytoplasmic linker associated protein 2 0.663342
SNTG1 syntrophin, gamma 1 0.663342
ITGB1BP1 integrin beta 1 binding protein 1 0.663342
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.663342
PTK6 protein tyrosine kinase 6 0.663342
PARD6A par-6 family cell polarity regulator alpha 0.663342
WWC1 WW and C2 domain containing 1 0.663342
S100A6 S100 calcium binding protein A6 0.663342
FERMT1 fermitin family member 1 0.663342
BCAR1 breast cancer anti-estrogen resistance 1 0.663342
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 0.663342
MTMR14 myotubularin related protein 14 0.663342
PALLD palladin, cytoskeletal associated protein 0.663342
AMOT angiomotin 0.663342
RPS3 ribosomal protein S3 0.663342
MYH9 myosin, heavy chain 9, non-muscle 0.663342
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma 0.663342
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.663342
MYO5A myosin VA (heavy chain 12, myoxin) 0.663342
PDE4A phosphodiesterase 4A, cAMP-specific 0.663342
S100B S100 calcium binding protein B 0.663342
MTSS1 metastasis suppressor 1 0.663342
PDE9A phosphodiesterase 9A 0.663342
ARF6 ADP-ribosylation factor 6 0.663342
CLIP1 CAP-GLY domain containing linker protein 1 0.663342
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.663342
CDK6 cyclin-dependent kinase 6 0.663342
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.663342
PODXL podocalyxin-like 0.663342
FAP fibroblast activation protein, alpha 0.663342
MYO6 myosin VI 0.663342
CD2AP CD2-associated protein 0.663342
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.663342
BMX BMX non-receptor tyrosine kinase 0.663342
KANK1 KN motif and ankyrin repeat domains 1 0.663342
EPHA2 EPH receptor A2 0.663342
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.663342
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.663342
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 0.663342
BAIAP2 BAI1-associated protein 2 0.663342
DIAPH1 diaphanous-related formin 1 0.663342
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 0.663342
MEFV Mediterranean fever 0.663342
VIL1 villin 1 0.663342
APC adenomatous polyposis coli 0.663342
S100A11 S100 calcium binding protein A11 0.663342
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.663342
AIF1 allograft inflammatory factor 1 0.663342
ITGAV integrin, alpha V 0.663342
MTM1 myotubularin 1 0.663342
SPATA13 spermatogenesis associated 13 0.663342
INPP5K inositol polyphosphate-5-phosphatase K 0.663342
INPP5J inositol polyphosphate-5-phosphatase J 0.663342
KIF18A kinesin family member 18A 0.663342
EZR ezrin 0.663342
CIB1 calcium and integrin binding 1 (calmyrin) 0.663342
TESC tescalcin 0.237908
FGD2 FYVE, RhoGEF and PH domain containing 2 0.237908
FGD3 FYVE, RhoGEF and PH domain containing 3 0.237908
PDPN podoplanin 0.237908
FGD1 FYVE, RhoGEF and PH domain containing 1 0.237908
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.237908
CYFIP1 cytoplasmic FMR1 interacting protein 1 0.237908
PLEK pleckstrin 0.237908
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 0.237908
TPM1 tropomyosin 1 (alpha) 0.237908
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 0.237908
ARFIP2 ADP-ribosylation factor interacting protein 2 0.237908
MYADM myeloid-associated differentiation marker 0.237908
ARF4 ADP-ribosylation factor 4 0.237908
FGD4 FYVE, RhoGEF and PH domain containing 4 0.237908
FGD5 FYVE, RhoGEF and PH domain containing 5 0.237908
EPS8 epidermal growth factor receptor pathway substrate 8 0.237908
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.237908
ALS2 amyotrophic lateral sclerosis 2 (juvenile) 0.237908
RINL Ras and Rab interactor-like 0.237908
DBNL drebrin-like 0.237908
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.237908
FGD6 FYVE, RhoGEF and PH domain containing 6 0.237908
EPS8L1 EPS8-like 1 0.237908
EPS8L2 EPS8-like 2 0.237908
CTTN cortactin 0.237908
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 0.098109
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 0.098109
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.098109
TLN1 talin 1 0.098109
TRPV4 transient receptor potential cation channel, subfamily V, member 4 0.098109
COBL cordon-bleu WH2 repeat protein 0.098109
LAYN layilin 0.098109
GAS7 growth arrest-specific 7 0.03318
MYO9B myosin IXB 0.03318
CDKL5 cyclin-dependent kinase-like 5 0.03318
FRMD4B FERM domain containing 4B 0.03318
TLN2 talin 2 0.03318
CIT citron rho-interacting serine/threonine kinase 0.03318
RHOA ras homolog family member A 0.03318
CDC37 cell division cycle 37 0.03318
EPB41L5 erythrocyte membrane protein band 4.1 like 5 0.03318
ANXA2 annexin A2 0.03318
PDLIM7 PDZ and LIM domain 7 (enigma) 0.03318
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 0.03318
ARHGAP1 Rho GTPase activating protein 1 0.03318
PLA2G4F phospholipase A2, group IVF 0.03318
FGR FGR proto-oncogene, Src family tyrosine kinase 0.03318
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.03318
RAB5A RAB5A, member RAS oncogene family 0.03318
TWF1 twinfilin actin binding protein 1 0.03318
CYTH3 cytohesin 3 0.03318
RDX radixin 0.03318
GSN gelsolin 0.03318
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.03318
SH2B2 SH2B adaptor protein 2 0.03318
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.03318