ruffle Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. (Gene Ontology, GO_0001726)
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Genes

253 proteins co-occuring with the ruffle cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 1.90355
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.90008
CDC42 cell division cycle 42 1.69706
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.61471
PLEK pleckstrin 1.32113
CTTN cortactin 1.31304
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.30389
ARF6 ADP-ribosylation factor 6 1.22568
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 1.2148
VAV2 vav 2 guanine nucleotide exchange factor 1.10002
MCF2 MCF.2 cell line derived transforming sequence 1.05842
PKN1 protein kinase N1 1.02082
CRK v-crk avian sarcoma virus CT10 oncogene homolog 1.00991
EZR ezrin 0.996123
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 0.941162
FN1 fibronectin 1 0.875948
LAYN layilin 0.864447
GRB2 growth factor receptor-bound protein 2 0.862149
VCL vinculin 0.860311
ELMO3 engulfment and cell motility 3 0.85342
CYTH1 cytohesin 1 0.839187
SPRY2 sprouty homolog 2 (Drosophila) 0.822664
PXN paxillin 0.821288
MSN moesin 0.820829
PLCD1 phospholipase C, delta 1 0.819452
SH3YL1 SH3 and SYLF domain containing 1 0.818075
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) 0.8089
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.804772
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.774101
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.770451
TIAM1 T-cell lymphoma invasion and metastasis 1 0.768171
NCKIPSD NCK interacting protein with SH3 domain 0.749546
PLEK2 pleckstrin 2 0.736014
ARF1 ADP-ribosylation factor 1 0.727494
ARF5 ADP-ribosylation factor 5 0.724365
ARHGAP1 Rho GTPase activating protein 1 0.720797
DOCK1 dedicator of cytokinesis 1 0.708808
NEXN nexilin (F actin binding protein) 0.70439
FLNA filamin A, alpha 0.699983
RAB34 RAB34, member RAS oncogene family 0.696465
EPS8L3 EPS8-like 3 0.689451
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.687264
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.673762
FSCN1 fascin actin-bundling protein 1 0.664664
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.662503
RDX radixin 0.655172
EPS8 epidermal growth factor receptor pathway substrate 8 0.655172
LIMA1 LIM domain and actin binding 1 0.65388
ABHD12B abhydrolase domain containing 12B 0.641001
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.639717
SPATA13 spermatogenesis associated 13 0.627761
CSF1 colony stimulating factor 1 (macrophage) 0.61883
PARVB parvin, beta 0.613318
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 0.60444
PTPN20 protein tyrosine phosphatase, non-receptor type 20 0.601909
IQGAP1 IQ motif containing GTPase activating protein 1 0.595173
WAS Wiskott-Aldrich syndrome 0.594753
TPM1 tropomyosin 1 (alpha) 0.58678
EGFR epidermal growth factor receptor 0.580922
SASH1 SAM and SH3 domain containing 1 0.579251
VAV1 vav 1 guanine nucleotide exchange factor 0.567169
CDKN2A cyclin-dependent kinase inhibitor 2A 0.551838
WASF2 WAS protein family, member 2 0.550599
EPS8L2 EPS8-like 2 0.540294
BCAR1 breast cancer anti-estrogen resistance 1 0.535772
ITGB1BP1 integrin beta 1 binding protein 1 0.535361
OCRL oculocerebrorenal syndrome of Lowe 0.532898
CYTH4 cytohesin 4 0.532488
EPS8L1 EPS8-like 1 0.530847
PLD2 phospholipase D2 0.530028
AMPH amphiphysin 0.524704
MTMR9 myotubularin related protein 9 0.524704
DLC1 DLC1 Rho GTPase activating protein 0.523476
RHOQ ras homolog family member Q 0.520615
FGD5 FYVE, RhoGEF and PH domain containing 5 0.518165
ARHGAP35 Rho GTPase activating protein 35 0.513677
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2 0.505537
NGF nerve growth factor (beta polypeptide) 0.505537
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 0.503912
DNM2 dynamin 2 0.491752
PLCG1 phospholipase C, gamma 1 0.489327
ARHGAP18 Rho GTPase activating protein 18 0.48005
STARD13 StAR-related lipid transfer (START) domain containing 13 0.478038
CALD1 caldesmon 1 0.477233
PLS1 plastin 1 0.471208
MYO6 myosin VI 0.469604
MYO18A myosin XVIIIA 0.45641
ILK integrin-linked kinase 0.454816
SNX9 sorting nexin 9 0.452427
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.452029
GBP5 guanylate binding protein 5 0.442896
LMBR1 limb development membrane protein 1 0.440916
AP3B2 adaptor-related protein complex 3, beta 2 subunit 0.438937
HRAS Harvey rat sarcoma viral oncogene homolog 0.437751
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.43538
ARHGAP24 Rho GTPase activating protein 24 0.431435
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26 0.428284
ELMO2 engulfment and cell motility 2 0.427891
IQGAP2 IQ motif containing GTPase activating protein 2 0.417294
JUN jun proto-oncogene 0.412992
PARD3B par-3 family cell polarity regulator beta 0.41221
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5 0.41143
ZNF675 zinc finger protein 675 0.409479
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.401304
PARVG parvin, gamma 0.400527
RAP2B RAP2B, member of RAS oncogene family 0.397423
INPP5B inositol polyphosphate-5-phosphatase, 75kDa 0.397035
EPB41 erythrocyte membrane protein band 4.1 0.39626
PALLD palladin, cytoskeletal associated protein 0.39471
NRG4 neuregulin 4 0.393549
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 0.391615
RIC8A RIC8 guanine nucleotide exchange factor A 0.390455
SAR1A secretion associated, Ras related GTPase 1A 0.390455
ARF3 ADP-ribosylation factor 3 0.390068
RAB1B RAB1B, member RAS oncogene family 0.387365
INPP5K inositol polyphosphate-5-phosphatase K 0.386979
GMFG glia maturation factor, gamma 0.378122
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.377354
MCF2L MCF.2 cell line derived transforming sequence-like 0.376202
PFN1 profilin 1 0.376202
TESC tescalcin 0.375818
BTK Bruton agammaglobulinemia tyrosine kinase 0.374666
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.373899
TF transferrin 0.370833
MTMR6 myotubularin related protein 6 0.366241
AIF1 allograft inflammatory factor 1 0.362804
ALS2 amyotrophic lateral sclerosis 2 (juvenile) 0.352901
VASP vasodilator-stimulated phosphoprotein 0.351762
DGKG diacylglycerol kinase, gamma 90kDa 0.350243
MAP3K12 mitogen-activated protein kinase kinase kinase 12 0.349863
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.347587
CPVL carboxypeptidase, vitellogenic-like 0.347208
FHOD1 formin homology 2 domain containing 1 0.343421
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.343421
FMN1 formin 1 0.338506
PODXL podocalyxin-like 0.337751
RHOB ras homolog family member B 0.337751
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 0.337373
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.335864
SPRR1A small proline-rich protein 1A 0.334733
NCK2 NCK adaptor protein 2 0.334356
PFN4 profilin family, member 4 0.332472
MARCKS myristoylated alanine-rich protein kinase C substrate 0.331342
TEK TEK tyrosine kinase, endothelial 0.326078
PSD pleckstrin and Sec7 domain containing 0.324951
MTMR3 myotubularin related protein 3 0.324576
CYTIP cytohesin 1 interacting protein 0.32345
GRB10 growth factor receptor-bound protein 10 0.321201
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.321201
ACTN4 actinin, alpha 4 0.320826
CDC42EP5 CDC42 effector protein (Rho GTPase binding) 5 0.319328
INS insulin 0.318579
PFN2 profilin 2 0.318579
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.318579
RECK reversion-inducing-cysteine-rich protein with kazal motifs 0.31783
GAS7 growth arrest-specific 7 0.316708
DGKA diacylglycerol kinase, alpha 80kDa 0.316334
PLS3 plastin 3 0.315586
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.314465
VAV3 vav 3 guanine nucleotide exchange factor 0.312224
NOX3 NADPH oxidase 3 0.312224
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.312224
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.311851
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.311478
AKAP11 A kinase (PRKA) anchor protein 11 0.309613
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.302912
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.297713
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6 0.294007
CD2AP CD2-associated protein 0.292897
ARHGAP22 Rho GTPase activating protein 22 0.288829
GRAP2 GRB2-related adaptor protein 2 0.282926
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) 0.282926
DGKB diacylglycerol kinase, beta 90kDa 0.27998
INPPL1 inositol polyphosphate phosphatase-like 1 0.276304
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.274835
MAP3K10 mitogen-activated protein kinase kinase kinase 10 0.273367
RAB5A RAB5A, member RAS oncogene family 0.2719
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 0.271533
ANK1 ankyrin 1, erythrocytic 0.268237
SPHK1 sphingosine kinase 1 0.267505
EPHB4 EPH receptor B4 0.267505
INPP5A inositol polyphosphate-5-phosphatase, 40kDa 0.266042
SOS1 son of sevenless homolog 1 (Drosophila) 0.265677
TYRO3 TYRO3 protein tyrosine kinase 0.264581
INSR insulin receptor 0.262025
SNX18 sorting nexin 18 0.258745
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 0.258381
RAB20 RAB20, member RAS oncogene family 0.25547
RUFY1 RUN and FYVE domain containing 1 0.255107
SNX33 sorting nexin 33 0.252927
PPP3R2 protein phosphatase 3, regulatory subunit B, beta 0.251839
ADGRG6 adhesion G protein-coupled receptor G6 0.249302
CRIP1 cysteine-rich protein 1 (intestinal) 0.244601
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.244601
TWF2 twinfilin actin binding protein 2 0.242437
TESK1 testis-specific kinase 1 0.240276
DAB2IP DAB2 interacting protein 0.236683
INPP5J inositol polyphosphate-5-phosphatase J 0.234533
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa 0.228108
ASB2 ankyrin repeat and SOCS box containing 2 0.225976
ARHGAP31 Rho GTPase activating protein 31 0.225622
THBS1 thrombospondin 1 0.223143
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain 0.223143
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.223143
SEBOX SEBOX homeobox 0.219265
WASH7P WAS protein family homolog 7 pseudogene 0.21716
FLNC filamin C, gamma 0.214714
RRAS related RAS viral (r-ras) oncogene homolog 0.214366
WASH6P WAS protein family homolog 6 pseudogene 0.214017
FSCN3 fascin actin-bundling protein 3, testicular 0.214017
TJP1 tight junction protein 1 0.212627
TUFT1 tuftelin 1 0.211587
WASH1 WAS protein family homolog 1 0.211587
BCAR3 breast cancer anti-estrogen resistance 3 0.209513
PDE4A phosphodiesterase 4A, cAMP-specific 0.207451
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.205399
SORBS2 sorbin and SH3 domain containing 2 0.203699
ADGRE1 adhesion G protein-coupled receptor E1 0.201672
FSCN2 fascin actin-bundling protein 2, retinal 0.201672
SNTG1 syntrophin, gamma 1 0.201335
KPTN kaptin (actin binding protein) 0.200999
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.200328
BAIAP2 BAI1-associated protein 2 0.198658
RET ret proto-oncogene 0.194045
CCL3 chemokine (C-C motif) ligand 3 0.191135
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.189222
LYN LYN proto-oncogene, Src family tyrosine kinase 0.18859
RAB10 RAB10, member RAS oncogene family 0.18796
MYO10 myosin X 0.18702
NBPF10 neuroblastoma breakpoint family, member 10 0.186708
SLA Src-like-adaptor 0.184853
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.181823
MICALL2 MICAL-like 2 0.18093
ADGRE2 adhesion G protein-coupled receptor E2 0.178011
SYNJ2 synaptojanin 2 0.177439
NISCH nischarin 0.177154
MAP2K3 mitogen-activated protein kinase kinase 3 0.176305
MYO1B myosin IB 0.175745
ADAP1 ArfGAP with dual PH domains 1 0.175188
CYTH2 cytohesin 2 0.174911
TMOD3 tropomodulin 3 (ubiquitous) 0.173814
CD44 CD44 molecule (Indian blood group) 0.171673
WIBG within bgcn homolog (Drosophila) 0.171673
MAPK8 mitogen-activated protein kinase 8 0.170888
RAB5C RAB5C, member RAS oncogene family 0.170114
PTK6 protein tyrosine kinase 6 0.167366
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3 0.164315
PDE9A phosphodiesterase 9A 0.160658
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 0.159268
BCR breakpoint cluster region 0.158692
WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 0.158502
SH3KBP1 SH3-domain kinase binding protein 1 0.157578
SKAP2 src kinase associated phosphoprotein 2 0.157397