ruffle Gene Set

Dataset GO Cellular Component Annotations 2015
Category structural or functional annotations
Type cellular component
Description Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. (Gene Ontology, GO_0001726)
External Link http://amigo.geneontology.org/amigo/term/GO:0001726
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Genes

87 proteins localized to the ruffle cellular component from the curated GO Cellular Component Annotations 2015 dataset.

Symbol Name
ACTN1 actinin, alpha 1
ALS2 amyotrophic lateral sclerosis 2 (juvenile)
AMOT angiomotin
ANXA2 annexin A2
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARF6 ADP-ribosylation factor 6
ARFIP2 ADP-ribosylation factor interacting protein 2
ARHGAP1 Rho GTPase activating protein 1
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
BAIAP2 BAI1-associated protein 2
BCAR1 breast cancer anti-estrogen resistance 1
CD2AP CD2-associated protein
CDK6 cyclin-dependent kinase 6
CIT citron rho-interacting serine/threonine kinase
CLIP1 CAP-GLY domain containing linker protein 1
COBL cordon-bleu WH2 repeat protein
CTTN cortactin
CYFIP1 cytoplasmic FMR1 interacting protein 1
CYTH3 cytohesin 3
DBNL drebrin-like
EZR ezrin
FGD1 FYVE, RhoGEF and PH domain containing 1
FGD2 FYVE, RhoGEF and PH domain containing 2
FGD3 FYVE, RhoGEF and PH domain containing 3
FGD4 FYVE, RhoGEF and PH domain containing 4
FGD5 FYVE, RhoGEF and PH domain containing 5
FGD6 FYVE, RhoGEF and PH domain containing 6
FRMD4B FERM domain containing 4B
GAS7 growth arrest-specific 7
GSN gelsolin
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
INPP5J inositol polyphosphate-5-phosphatase J
INPP5K inositol polyphosphate-5-phosphatase K
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB1BP1 integrin beta 1 binding protein 1
KIF18A kinesin family member 18A
KLHL2 kelch-like family member 2
KLHL41 kelch-like family member 41
LAYN layilin
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
MEFV Mediterranean fever
MKLN1 muskelin 1, intracellular mediator containing kelch motifs
MTM1 myotubularin 1
MTMR14 myotubularin related protein 14
MTSS1 metastasis suppressor 1
MYADM myeloid-associated differentiation marker
MYH9 myosin, heavy chain 9, non-muscle
MYO10 myosin X
MYO1C myosin IC
MYO5A myosin VA (heavy chain 12, myoxin)
MYO6 myosin VI
MYO9B myosin IXB
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PALLD palladin, cytoskeletal associated protein
PARD6A par-6 family cell polarity regulator alpha
PDLIM7 PDZ and LIM domain 7 (enigma)
PDPN podoplanin
PLCG1 phospholipase C, gamma 1
PODXL podocalyxin-like
PSD pleckstrin and Sec7 domain containing
PTK6 protein tyrosine kinase 6
RAB22A RAB22A, member RAS oncogene family
RAB5A RAB5A, member RAS oncogene family
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RDX radixin
RINL Ras and Rab interactor-like
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
S100A11 S100 calcium binding protein A11
S100A6 S100 calcium binding protein A6
S100B S100 calcium binding protein B
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SH2B2 SH2B adaptor protein 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNX5 sorting nexin 5
SNX9 sorting nexin 9
TESC tescalcin
TLN1 talin 1
TLN2 talin 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRPM7 transient receptor potential cation channel, subfamily M, member 7
VIL1 villin 1
WASF2 WAS protein family, member 2
WIPF1 WAS/WASL interacting protein family, member 1