runx1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description runt-related transcription factor 1|Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 861)
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Genes

88 genes co-occuring with the biological term runx1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALOX12 arachidonate 12-lipoxygenase
ASXL1 additional sex combs like transcriptional regulator 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BLK BLK proto-oncogene, Src family tyrosine kinase
BLNK B-cell linker
CARM1 coactivator-associated arginine methyltransferase 1
CBFB core-binding factor, beta subunit
CCL3 chemokine (C-C motif) ligand 3
CD34 CD34 molecule
CD4 CD4 molecule
CDK1 cyclin-dependent kinase 1
CDK6 cyclin-dependent kinase 6
CSF3R colony stimulating factor 3 receptor (granulocyte)
ELK1 ELK1, member of ETS oncogene family
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV6 ets variant 6
EVI5 ecotropic viral integration site 5
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FLT3 fms-related tyrosine kinase 3
FOXO3 forkhead box O3
FOXP3 forkhead box P3
GATA1 GATA binding protein 1 (globin transcription factor 1)
H19 H19, imprinted maternally expressed transcript (non-protein coding)
HDAC1 histone deacetylase 1
HDAC3 histone deacetylase 3
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIST3H3 histone cluster 3, H3
IL2 interleukin 2
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGAV integrin, alpha V
KDM6A lysine (K)-specific demethylase 6A
KMT2A lysine (K)-specific methyltransferase 2A
KRTAP5-1 keratin associated protein 5-1
LGALS3 lectin, galactoside-binding, soluble, 3
LPXN leupaxin
MACROD1 MACRO domain containing 1
MEF2A myocyte enhancer factor 2A
MIR27A microRNA 27a
MIR675 microRNA 675
MYH10 myosin, heavy chain 10, non-muscle
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAM1 neural cell adhesion molecule 1
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NF1 neurofibromin 1
NFE2 nuclear factor, erythroid 2
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR4A3 nuclear receptor subfamily 4, group A, member 3
PF4 platelet factor 4
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PITHD1 PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1
PLAU plasminogen activator, urokinase
PRDM16 PR domain containing 16
PRKCB protein kinase C, beta
PRKCQ protein kinase C, theta
PRMT1 protein arginine methyltransferase 1
PRMT6 protein arginine methyltransferase 6
RAG1 recombination activating gene 1
RUNX1 runt-related transcription factor 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
RUNX2 runt-related transcription factor 2
RUNX3 runt-related transcription factor 3
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SIN3A SIN3 transcription regulator family member A
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMAD6 SMAD family member 6
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SPI1 Spi-1 proto-oncogene
SRSF2 serine/arginine-rich splicing factor 2
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAL1 T-cell acute lymphocytic leukemia 1
TET2 tet methylcytosine dioxygenase 2
TGFB1 transforming growth factor, beta 1
THADA thyroid adenoma associated
TIMP1 TIMP metallopeptidase inhibitor 1
TLX1 T-cell leukemia homeobox 1
TLX3 T-cell leukemia homeobox 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TP63 tumor protein p63
TRD T cell receptor delta locus