runx1_18671852_e8dot5_lof_mouse_gpl1261_gds1511 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations
Category transcriptomics
Type transcription factor perturbation
Description transcription factor perturbation identified as [TF gene symbol]_[publication PMID]_[cell or tissue]_[perturbation]_[organism]_[GEO platform]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GDS1511
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Genes

231 genes differentially expressed following the runx1_18671852_e8dot5_lof_mouse_gpl1261_gds1511 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.

increased expression

Symbol Name Standardized Value
ERAP1 endoplasmic reticulum aminopeptidase 1 0.21348
KLRK1 killer cell lectin-like receptor subfamily K, member 1 0.209556
LRRK2 leucine-rich repeat kinase 2 0.209015
VSNL1 visinin-like 1 0.206902
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 0.204615
SRSF3 serine/arginine-rich splicing factor 3 0.197587
BCLAF1 BCL2-associated transcription factor 1 0.195244
KBTBD7 kelch repeat and BTB (POZ) domain containing 7 0.194516
GMPS guanine monphosphate synthase 0.192961
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 0.190268
MYF6 myogenic factor 6 (herculin) 0.183262
SIX3 SIX homeobox 3 0.180995
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant 0.174786
ZEB1 zinc finger E-box binding homeobox 1 0.168632
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.164186
CRB3 crumbs family member 3 0.162345
SNURF SNRPN upstream reading frame 0.159081
RTN4 reticulon 4 0.158172
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 0.141883
SSNA1 Sjogren syndrome nuclear autoantigen 1 0.140401
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 0.138971
HRSP12 heat-responsive protein 12 0.136684
LOC100505841 zinc finger protein 474-like 0.134609
DTWD1 DTW domain containing 1 0.134578
RP1 retinitis pigmentosa 1 (autosomal dominant) 0.132236
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 0.130871
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.128518
CDCA4 cell division cycle associated 4 0.120447
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa 0.119312
QPRT quinolinate phosphoribosyltransferase 0.118504
HAUS7 HAUS augmin-like complex, subunit 7 0.118023
CYB5R3 cytochrome b5 reductase 3 0.117542
SRBD1 S1 RNA binding domain 1 0.112245
GXYLT2 glucoside xylosyltransferase 2 0.105947
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 0.104592
DNAI1 dynein, axonemal, intermediate chain 1 0.104181
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 0.096782
ISPD isoprenoid synthase domain containing 0.096452
ACADSB acyl-CoA dehydrogenase, short/branched chain 0.095375
TSPAN13 tetraspanin 13 0.092349
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 0.091265
SOX5 SRY (sex determining region Y)-box 5 0.089387
UBQLNL ubiquilin-like 0.088531
PPIC peptidylprolyl isomerase C (cyclophilin C) 0.086914
GLIS3 GLIS family zinc finger 3 0.084732
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa 0.084178
AGFG1 ArfGAP with FG repeats 1 0.083493
MMD monocyte to macrophage differentiation-associated 0.079523
RWDD2A RWD domain containing 2A 0.079004
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4 0.072073
AGMO alkylglycerol monooxygenase 0.070031
SMIM19 small integral membrane protein 19 0.068126
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.063797
TEX38 testis expressed 38 0.062791
RGS5 regulator of G-protein signaling 5 0.062448
RCOR3 REST corepressor 3 0.060833
PTPN5 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) 0.058018
KLC4 kinesin light chain 4 0.045778
FAM8A1 family with sequence similarity 8, member A1 0.039916
QKI QKI, KH domain containing, RNA binding 0.036655
HID1 HID1 domain containing 0.034737
ATRNL1 attractin-like 1 0.033795
RBM18 RNA binding motif protein 18 0.030777
EMCN endomucin 0.030614
U2SURP U2 snRNP-associated SURP domain containing 0.028796
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.022791
STIM2 stromal interaction molecule 2 0.018928
RSPH3 radial spoke 3 homolog (Chlamydomonas) 0.016946
LYRM5 LYR motif containing 5 0.015589
PMP2 peripheral myelin protein 2 0.009768
ELOVL7 ELOVL fatty acid elongase 7 0.007309
DCTPP1 dCTP pyrophosphatase 1 0.006701
TDO2 tryptophan 2,3-dioxygenase 0.006094
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma 0.002489

decreased expression

Symbol Name Standardized Value
PRRC2A proline-rich coiled-coil 2A -1.35072
FICD FIC domain containing -1.31238
EIF4E2 eukaryotic translation initiation factor 4E family member 2 -1.30016
WDFY4 WDFY family member 4 -1.27641
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) -1.26468
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B -1.25528
TRPC3 transient receptor potential cation channel, subfamily C, member 3 -1.24758
KCTD6 potassium channel tetramerization domain containing 6 -1.21822
IAH1 isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae) -1.1951
TRIP11 thyroid hormone receptor interactor 11 -1.16991
ZCCHC6 zinc finger, CCHC domain containing 6 -1.13663
GRN granulin -1.13219
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme -1.0935
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 -1.0922
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 -1.08962
AGMAT agmatine ureohydrolase (agmatinase) -1.08309
WISP2 WNT1 inducible signaling pathway protein 2 -1.02245
EDRF1 erythroid differentiation regulatory factor 1 -1.00098
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit -0.993985
BSDC1 BSD domain containing 1 -0.991078
NFXL1 nuclear transcription factor, X-box binding-like 1 -0.989471
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2 -0.985132
KLHDC3 kelch domain containing 3 -0.96802
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase -0.951045
DMWD dystrophia myotonica, WD repeat containing -0.944332
TCF25 transcription factor 25 (basic helix-loop-helix) -0.942699
MAP7 microtubule-associated protein 7 -0.942027
AAR2 AAR2 splicing factor homolog (S. cerevisiae) -0.924159
RBL2 retinoblastoma-like 2 -0.924159
DNM2 dynamin 2 -0.908549
MCPH1 microcephalin 1 -0.886139
LEMD3 LEM domain containing 3 -0.883519
PTPRS protein tyrosine phosphatase, receptor type, S -0.880023
WWTR1 WW domain containing transcription regulator 1 -0.860101
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae) -0.850089
FOXS1 forkhead box S1 -0.837787
GIPR gastric inhibitory polypeptide receptor -0.834465
TLN1 talin 1 -0.822254
TRIM62 tripartite motif containing 62 -0.820563
LYZL6 lysozyme-like 6 -0.819567
MAP3K6 mitogen-activated protein kinase kinase kinase 6 -0.817879
DSP desmoplakin -0.794992
CD2BP2 CD2 (cytoplasmic tail) binding protein 2 -0.793621
RHBDD2 rhomboid domain containing 2 -0.793007
RPSA ribosomal protein SA -0.787851
CSRP2BP CSRP2 binding protein -0.769189
FGFR3 fibroblast growth factor receptor 3 -0.768785
SLC38A10 solute carrier family 38, member 10 -0.758723
WDR13 WD repeat domain 13 -0.751416
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 -0.75133
PLAC8L1 PLAC8-like 1 -0.747292
N6AMT2 N-6 adenine-specific DNA methyltransferase 2 (putative) -0.746694
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.745287
SETDB2 SET domain, bifurcated 2 -0.74499
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 -0.714536
IL36G interleukin 36, gamma -0.712837
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 -0.706811
OTUD5 OTU deubiquitinase 5 -0.691084
TRIM8 tripartite motif containing 8 -0.686005
PTPRK protein tyrosine phosphatase, receptor type, K -0.683799
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal -0.681756
FNDC7 fibronectin type III domain containing 7 -0.675756
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) -0.675111
SEZ6L seizure related 6 homolog (mouse)-like -0.670881
PLB1 phospholipase B1 -0.663111
AUTS2 autism susceptibility candidate 2 -0.660028
OPCML opioid binding protein/cell adhesion molecule-like -0.654988
OMP olfactory marker protein -0.646147
ATG4D autophagy related 4D, cysteine peptidase -0.643126
ADAP2 ArfGAP with dual PH domains 2 -0.642613
KDM6A lysine (K)-specific demethylase 6A -0.641223
TMED5 transmembrane emp24 protein transport domain containing 5 -0.639193
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 -0.63394
CDC34 cell division cycle 34 -0.624588
SUSD3 sushi domain containing 3 -0.621832
NANS N-acetylneuraminic acid synthase -0.619843
RILPL2 Rab interacting lysosomal protein-like 2 -0.619364
MAGED2 melanoma antigen family D2 -0.618475
NMRK1 nicotinamide riboside kinase 1 -0.61483
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 -0.612483
BCL2 B-cell CLL/lymphoma 2 -0.610552
GPR85 G protein-coupled receptor 85 -0.605296
EXT1 exostosin glycosyltransferase 1 -0.603732
PVR poliovirus receptor -0.602699
TMEM259 transmembrane protein 259 -0.59738
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.593413
CBX7 chromobox homolog 7 -0.580493
WDR62 WD repeat domain 62 -0.577867
WDFY1 WD repeat and FYVE domain containing 1 -0.575975
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A -0.575622
MMP11 matrix metallopeptidase 11 -0.570147
NUP214 nucleoporin 214kDa -0.563489
KLRB1 killer cell lectin-like receptor subfamily B, member 1 -0.56293
SUSD4 sushi domain containing 4 -0.555852
STIM1 stromal interaction molecule 1 -0.554712
UCN urocortin -0.552058
MAPKBP1 mitogen-activated protein kinase binding protein 1 -0.551845
CTSB cathepsin B -0.542221
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.531444
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast) -0.530263
MX1 MX dynamin-like GTPase 1 -0.526387
VMAC vimentin-type intermediate filament associated coiled-coil protein -0.525043
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -0.522764
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha -0.518506
ADAM15 ADAM metallopeptidase domain 15 -0.515343
TFRC transferrin receptor -0.514337
PISD phosphatidylserine decarboxylase -0.514248
MC3R melanocortin 3 receptor -0.511466
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -0.50544
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -0.500828
CACNB3 calcium channel, voltage-dependent, beta 3 subunit -0.498939
CCDC7 coiled-coil domain containing 7 -0.496787
PKN3 protein kinase N3 -0.495715
POFUT1 protein O-fucosyltransferase 1 -0.494573
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) -0.493522
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.48757
ZBTB40 zinc finger and BTB domain containing 40 -0.487217
SYNC syncoilin, intermediate filament protein -0.479418
LETM1 leucine zipper-EF-hand containing transmembrane protein 1 -0.476642
NR2F2 nuclear receptor subfamily 2, group F, member 2 -0.473491
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) -0.469318
USP43 ubiquitin specific peptidase 43 -0.461749
IRF3 interferon regulatory factor 3 -0.456588
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2 -0.448711
PEG10 paternally expressed 10 -0.445643
PODXL podocalyxin-like -0.444253
ZPBP zona pellucida binding protein -0.444036
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -0.442415
GCSAM germinal center-associated, signaling and motility -0.441679
LHX8 LIM homeobox 8 -0.060317
MEX3B mex-3 RNA binding family member B -0.059551
MYL12B myosin, light chain 12B, regulatory -0.058552
MMP17 matrix metallopeptidase 17 (membrane-inserted) -0.055558
IFI44L interferon-induced protein 44-like -0.050787
HELLS helicase, lymphoid-specific -0.04657
ATXN1L ataxin 1-like -0.043915
KLHL24 kelch-like family member 24 -0.036361
SYNPO2 synaptopodin 2 -0.035955
MYOC myocilin, trabecular meshwork inducible glucocorticoid response -0.034271
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 -0.033816
IDI1 isopentenyl-diphosphate delta isomerase 1 -0.032907
NOV nephroblastoma overexpressed -0.028564
MDM1 Mdm1 nuclear protein homolog (mouse) -0.028214
E2F5 E2F transcription factor 5, p130-binding -0.026059
CFAP36 cilia and flagella associated protein 36 -0.021958
PCNA proliferating cell nuclear antigen -0.021958
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) -0.019834
CYB5R4 cytochrome b5 reductase 4 -0.019291
KLK7 kallikrein-related peptidase 7 -0.019064
TBR1 T-box, brain, 1 -0.017403
ACOT2 acyl-CoA thioesterase 2 -0.016196
SPO11 SPO11 meiotic protein covalently bound to DSB -0.015258
HOXA10 homeobox A10 -0.008415
TNRC6C trinucleotide repeat containing 6C -0.008137
TNNI3 troponin I type 3 (cardiac) -0.006253
RASIP1 Ras interacting protein 1 -0.002709
PCDHB17P protocadherin beta 17 pseudogene -0.002662