runx2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description runt-related transcription factor 2|This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 860)
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Genes

113 genes co-occuring with the biological term runx2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALPL alkaline phosphatase, liver/bone/kidney
AR androgen receptor
ATF4 activating transcription factor 4
BGLAP bone gamma-carboxyglutamate (gla) protein
BIRC3 baculoviral IAP repeat containing 3
BIRC5 baculoviral IAP repeat containing 5
BMP2 bone morphogenetic protein 2
CBFB core-binding factor, beta subunit
CD44 CD44 molecule (Indian blood group)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK1 cyclin-dependent kinase 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
COL10A1 collagen, type X, alpha 1
COL1A1 collagen, type I, alpha 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DCLK1 doublecortin-like kinase 1
DDR2 discoidin domain receptor tyrosine kinase 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLX5 distal-less homeobox 5
EHMT2 euchromatic histone-lysine N-methyltransferase 2
EPAS1 endothelial PAS domain protein 1
ESR1 estrogen receptor 1
EWSR1 EWS RNA-binding protein 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FGF2 fibroblast growth factor 2 (basic)
FGF23 fibroblast growth factor 23
FGFR2 fibroblast growth factor receptor 2
FHL2 four and a half LIM domains 2
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FOXO1 forkhead box O1
GDF2 growth differentiation factor 2
GH1 growth hormone 1
GNAS GNAS complex locus
GPX3 glutathione peroxidase 3
GTF2I general transcription factor IIi
HDAC1 histone deacetylase 1
HDAC3 histone deacetylase 3
HDAC4 histone deacetylase 4
HDAC6 histone deacetylase 6
HDAC7 histone deacetylase 7
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HHIP hedgehog interacting protein
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
IBSP integrin-binding sialoprotein
IFITM1 interferon induced transmembrane protein 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IHH indian hedgehog
IL1B interleukin 1, beta
IP6K1 inositol hexakisphosphate kinase 1
IP6K2 inositol hexakisphosphate kinase 2
ITGAV integrin, alpha V
KDR kinase insert domain receptor
KLF10 Kruppel-like factor 10
LEP leptin
LGALS3 lectin, galactoside-binding, soluble, 3
LRP5 low density lipoprotein receptor-related protein 5
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK14 mitogen-activated protein kinase 14
MEF2C myocyte enhancer factor 2C
MIR106A microRNA 106a
MIR146A microRNA 146a
MIR17 microRNA 17
MIR30A microRNA 30a
MIR30B microRNA 30b
MIR31 microRNA 31
MIR338 microRNA 338
MMP13 matrix metallopeptidase 13
MMP2 matrix metallopeptidase 2
MSX2 msh homeobox 2
NELL1 NEL-like 1 (chicken)
NFIL3 nuclear factor, interleukin 3 regulated
NOTCH1 notch 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PCIF1 PDX1 C-terminal inhibiting factor 1
PDLIM7 PDZ and LIM domain 7 (enigma)
PIP prolactin-induced protein
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PPARG peroxisome proliferator-activated receptor gamma
PTHLH parathyroid hormone-like hormone
RB1 retinoblastoma 1
RBM14 RNA binding motif protein 14
RUNX1 runt-related transcription factor 1
RUNX2 runt-related transcription factor 2
SMAD5 SMAD family member 5
SMAD6 SMAD family member 6
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SOX9 SRY (sex determining region Y)-box 9
SP7 Sp7 transcription factor
SPP1 secreted phosphoprotein 1
SRA1 steroid receptor RNA activator 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TGFB1 transforming growth factor, beta 1
TIMP1 TIMP metallopeptidase inhibitor 1
TNF tumor necrosis factor
TP63 tumor protein p63
TSSC1 tumor suppressing subtransferable candidate 1
TWIST1 twist family bHLH transcription factor 1
TWIST2 twist family bHLH transcription factor 2
UBTF upstream binding transcription factor, RNA polymerase I
VEGFA vascular endothelial growth factor A
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WWOX WW domain containing oxidoreductase
WWP1 WW domain containing E3 ubiquitin protein ligase 1
WWTR1 WW domain containing transcription regulator 1
YAP1 Yes-associated protein 1
ZBTB16 zinc finger and BTB domain containing 16