runx3 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description runt-related transcription factor 3|This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 864)
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Genes

64 genes co-occuring with the biological term runx3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BIRC5 baculoviral IAP repeat containing 5
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CASZ1 castor zinc finger 1
CCND1 cyclin D1
CD36 CD36 molecule (thrombospondin receptor)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
CLDN1 claudin 1
CLU clusterin
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DAPK1 death-associated protein kinase 1
DMBT1 deleted in malignant brain tumors 1
DNMT1 DNA (cytosine-5-)-methyltransferase 1
EGFR epidermal growth factor receptor
EHMT2 euchromatic histone-lysine N-methyltransferase 2
EP300 E1A binding protein p300
ESR1 estrogen receptor 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FOXO3 forkhead box O3
FOXP3 forkhead box P3
GSDMA gasdermin A
HDAC1 histone deacetylase 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
ICAM3 intercellular adhesion molecule 3
IFNG interferon, gamma
IGF2 insulin-like growth factor 2
JAG1 jagged 1
KRAS Kirsten rat sarcoma viral oncogene homolog
LMO1 LIM domain only 1 (rhombotin 1)
MAP3K10 mitogen-activated protein kinase kinase kinase 10
MGMT O-6-methylguanine-DNA methyltransferase
MIR106A microRNA 106a
MIR106B microRNA 106b
MIR130A microRNA 130a
MIR148A microRNA 148a
MIR30A microRNA 30a
MLH1 mutL homolog 1
MMP9 matrix metallopeptidase 9
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NCR1 natural cytotoxicity triggering receptor 1
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NGFR nerve growth factor receptor
NOTCH1 notch 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
RUNX1 runt-related transcription factor 1
RUNX3 runt-related transcription factor 3
SLURP1 secreted LY6/PLAUR domain containing 1
SP7 Sp7 transcription factor
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP1 TIMP metallopeptidase inhibitor 1
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2
TP53 tumor protein p53
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VIM vimentin
ZBTB7B zinc finger and BTB domain containing 7B
ZFHX3 zinc finger homeobox 3