sarcoidosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A hypersensitivity reaction type IV disease characterized by the growth of collections of inflammatory cells (granulomas) in multiple organs. (Human Disease Ontology, DOID_11335)
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Genes

272 genes co-occuring with the disease sarcoidosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
ACE angiotensin I converting enzyme 2.68557
BTNL2 butyrophilin-like 2 1.95018
CD4 CD4 molecule 1.89731
LYZ lysozyme 1.88851
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 1.56844
TNF tumor necrosis factor 1.4149
IL2RA interleukin 2 receptor, alpha 1.40876
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 1.38472
ANXA11 annexin A11 1.37817
HLA-C major histocompatibility complex, class I, C 1.24819
NOD2 nucleotide-binding oligomerization domain containing 2 1.24515
IL2 interleukin 2 1.16606
PTH parathyroid hormone 1.13924
CHIT1 chitinase 1 (chitotriosidase) 1.11099
CD79A CD79a molecule, immunoglobulin-associated alpha 1.08873
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 1.08244
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.07992
ALB albumin 1.06606
C10ORF67 chromosome 10 open reading frame 67 1.0606
NELFCD negative elongation factor complex member C/D 1.0463
CD68 CD68 molecule 1.0265
IL1B interleukin 1, beta 0.997392
IL18 interleukin 18 0.913492
RBM12B RNA binding motif protein 12B 0.909376
NOD1 nucleotide-binding oligomerization domain containing 1 0.892538
BEND6 BEN domain containing 6 0.887208
KIAA1586 KIAA1586 0.887208
ALPP alkaline phosphatase, placental 0.878195
HLA-DQB3 major histocompatibility complex, class II, DQ beta 3 0.874919
ALPPL2 alkaline phosphatase, placental-like 2 0.868777
ALPL alkaline phosphatase, liver/bone/kidney 0.867959
CCL16 chemokine (C-C motif) ligand 16 0.838066
CXCL10 chemokine (C-X-C motif) ligand 10 0.822488
GNG8 guanine nucleotide binding protein (G protein), gamma 8 0.820026
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 0.813873
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.802795
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.797052
CXCR3 chemokine (C-X-C motif) receptor 3 0.794591
ICAM1 intercellular adhesion molecule 1 0.779023
OAT ornithine aminotransferase 0.775341
MUC1 mucin 1, cell surface associated 0.770844
CCL3 chemokine (C-C motif) ligand 3 0.761862
FN1 fibronectin 1 0.753713
IFNA1 interferon, alpha 1 0.753306
HLA-A major histocompatibility complex, class I, A 0.743547
DCXR dicarbonyl/L-xylulose reductase 0.742735
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.735838
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 0.728143
ADA adenosine deaminase 0.724098
B2M beta-2-microglobulin 0.708767
MRAP melanocortin 2 receptor accessory protein 0.707559
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.705144
TGFB1 transforming growth factor, beta 1 0.699116
OTUD1 OTU deubiquitinase 1 0.691896
CXCL9 chemokine (C-X-C motif) ligand 9 0.6791
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.668742
BTNL8 butyrophilin-like 8 0.667152
BTNL3 butyrophilin-like 3 0.667152
CRP C-reactive protein, pentraxin-related 0.659611
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.659215
CCL13 chemokine (C-C motif) ligand 13 0.651694
CCDC88B coiled-coil domain containing 88B 0.62885
POMC proopiomelanocortin 0.623359
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.621008
B3GAT1 beta-1,3-glucuronyltransferase 1 0.610448
CCL2 chemokine (C-C motif) ligand 2 0.609276
IL6 interleukin 6 0.604201
ACPP acid phosphatase, prostate 0.6003
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.59991
IL1A interleukin 1, alpha 0.591727
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.589779
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 0.588612
SST somatostatin 0.585887
CD69 CD69 molecule 0.585497
CD80 CD80 molecule 0.573828
ORM1 orosomucoid 1 0.565277
CD276 CD276 molecule 0.5645
PTPN23 protein tyrosine phosphatase, non-receptor type 23 0.560227
IL12RB2 interleukin 12 receptor, beta 2 0.558285
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 0.555568
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.548971
LTA lymphotoxin alpha 0.547419
IFNA10 interferon, alpha 10 0.542379
PCDHGC3 protocadherin gamma subfamily C, 3 0.533088
CXCL8 chemokine (C-X-C motif) ligand 8 0.532314
BBS2 Bardet-Biedl syndrome 2 0.528449
IL10 interleukin 10 0.526518
ZNF451 zinc finger protein 451 0.524588
SFTPD surfactant protein D 0.517265
CCR2 chemokine (C-C motif) receptor 2 0.513802
TLR2 toll-like receptor 2 0.50459
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.476393
CXCL11 chemokine (C-X-C motif) ligand 11 0.476014
IL1RN interleukin 1 receptor antagonist 0.473361
S100A9 S100 calcium binding protein A9 0.470711
AVP arginine vasopressin 0.466172
CCL17 chemokine (C-C motif) ligand 17 0.455978
PLA2R1 phospholipase A2 receptor 1, 180kDa 0.454847
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.442418
PTHLH parathyroid hormone-like hormone 0.442042
RIPK2 receptor-interacting serine-threonine kinase 2 0.441666
FOXP3 forkhead box P3 0.441666
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.436402
TLR4 toll-like receptor 4 0.436402
SPP1 secreted phosphoprotein 1 0.434899
BTNL9 butyrophilin-like 9 0.434899
SELL selectin L 0.434524
STAB1 stabilin 1 0.434524
CD86 CD86 molecule 0.430017
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 0.427765
HP haptoglobin 0.427765
HPR haptoglobin-related protein 0.421765
TFRC transferrin receptor 0.416896
IFNG interferon, gamma 0.416147
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.416147
HLA-DMA major histocompatibility complex, class II, DM alpha 0.415024
KNG1 kininogen 1 0.41465
ANKRD42 ankyrin repeat domain 42 0.414276
MCEE methylmalonyl CoA epimerase 0.413527
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.404184
IFNA2 interferon, alpha 2 0.403438
CCL4 chemokine (C-C motif) ligand 4 0.403438
FKBP1C FK506 binding protein 1C 0.392629
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.391885
PRTN3 proteinase 3 0.388909
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.384822
CD27 CD27 molecule 0.376661
IL12RB1 interleukin 12 receptor, beta 1 0.36704
ADAMDEC1 ADAM-like, decysin 1 0.364454
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit 0.364085
CTSK cathepsin K 0.363716
CD163 CD163 molecule 0.362609
SAA2 serum amyloid A2 0.358551
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.357814
YIPF4 Yip1 domain family, member 4 0.357446
MRC1 mannose receptor, C type 1 0.354868
CXCR6 chemokine (C-X-C motif) receptor 6 0.354499
ACTB actin, beta 0.348614
CEND1 cell cycle exit and neuronal differentiation 1 0.33651
HSPA1L heat shock 70kDa protein 1-like 0.33651
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase) 0.334681
HLA-B major histocompatibility complex, class I, B 0.332121
MMP7 matrix metallopeptidase 7 0.33066
CXCL5 chemokine (C-X-C motif) ligand 5 0.320817
NCAM1 neural cell adhesion molecule 1 0.320454
ACTG1 actin gamma 1 0.319363
DHODH dihydroorotate dehydrogenase (quinone) 0.318272
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.312102
HDAC11 histone deacetylase 11 0.312102
CD19 CD19 molecule 0.30631
TLR9 toll-like receptor 9 0.304864
TMSB15A thymosin beta 15a 0.301254
MKI67 marker of proliferation Ki-67 0.300533
IL7R interleukin 7 receptor 0.299452
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.297651
NCF4 neutrophil cytosolic factor 4, 40kDa 0.28151
MST1 macrophage stimulating 1 0.280439
MMP1 matrix metallopeptidase 1 0.280439
VTCN1 V-set domain containing T cell activation inhibitor 1 0.27794
TNC tenascin C 0.27687
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 0.274732
TF transferrin 0.267267
SLC35B4 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 0.26514
IL15 interleukin 15 0.264431
IGF1 insulin-like growth factor 1 (somatomedin C) 0.262306
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.255594
SAG S-antigen; retina and pineal gland (arrestin) 0.255241
STAT1 signal transducer and activator of transcription 1, 91kDa 0.254536
RPL32 ribosomal protein L32 0.253479
MPO myeloperoxidase 0.251015
CD83 CD83 molecule 0.250663
CCL15 chemokine (C-C motif) ligand 15 0.243645
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.241546
CXCL16 chemokine (C-X-C motif) ligand 16 0.240148
PRDX1 peroxiredoxin 1 0.238752
LCK LCK proto-oncogene, Src family tyrosine kinase 0.238403
IL1R1 interleukin 1 receptor, type I 0.233878
TCHH trichohyalin 0.23353
IL22RA2 interleukin 22 receptor, alpha 2 0.230755
GRP gastrin-releasing peptide 0.230409
FSCN3 fascin actin-bundling protein 3, testicular 0.22937
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.225573
CCL19 chemokine (C-C motif) ligand 19 0.22454
PDGFB platelet-derived growth factor beta polypeptide 0.223853
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 0.223165
CP ceruloplasmin (ferroxidase) 0.219057
CCL20 chemokine (C-C motif) ligand 20 0.212271
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 0.207912
FSCN2 fascin actin-bundling protein 2, retinal 0.205585
PPT1 palmitoyl-protein thioesterase 1 0.19742
CCL5 chemokine (C-C motif) ligand 5 0.193285
FABP4 fatty acid binding protein 4, adipocyte 0.192971
CD22 CD22 molecule 0.189551
LEFTY1 left-right determination factor 1 0.188632
CALCA calcitonin-related polypeptide alpha 0.187113
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 0.186811
C9 complement component 9 0.18591
BAG2 BCL2-associated athanogene 2 0.182957
LRRC32 leucine rich repeat containing 32 0.179802
CDSN corneodesmosin 0.17896
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 0.178682
ORM2 orosomucoid 2 0.173832
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 0.171286
LPP LIM domain containing preferred translocation partner in lipoma 0.170789
CCR8 chemokine (C-C motif) receptor 8 0.170054
HYLS1 hydrolethalus syndrome 1 0.167915
ATN1 atrophin 1 0.167915
PRDX5 peroxiredoxin 5 0.165435
GPS1 G protein pathway suppressor 1 0.164786
IL4 interleukin 4 0.164786
HSPA4 heat shock 70kDa protein 4 0.162306
CASR calcium-sensing receptor 0.161523
SHOX2 short stature homeobox 2 0.160948
CD1C CD1c molecule 0.15948
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 0.15948
ANPEP alanyl (membrane) aminopeptidase 0.159302
IL12B interleukin 12B 0.158097
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 0.139485
AURKC aurora kinase C 0.139397
FEV FEV (ETS oncogene family) 0.137354
LAMP3 lysosomal-associated membrane protein 3 0.137152
CMA1 chymase 1, mast cell 0.136436
DCD dermcidin 0.136267
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) 0.135218
GYPA glycophorin A (MNS blood group) 0.134792
CA5B carbonic anhydrase VB, mitochondrial 0.134324
ADK adenosine kinase 0.133811
AQP5 aquaporin 5 0.133506
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 0.132518
JUP junction plakoglobin 0.13218
TLR8 toll-like receptor 8 0.131941
EFS embryonal Fyn-associated substrate 0.131519
TNNT2 troponin T type 2 (cardiac) 0.131392
TREM1 triggering receptor expressed on myeloid cells 1 0.130444
SLAMF6 SLAM family member 6 0.129574
ADIPOR2 adiponectin receptor 2 0.129437
KLF10 Kruppel-like factor 10 0.128321
XCL1 chemokine (C motif) ligand 1 0.127845
FSCN1 fascin actin-bundling protein 1 0.127758
MECOM MDS1 and EVI1 complex locus 0.126949
GLS glutaminase 0.125814
OPTN optineurin 0.125447
OLFM4 olfactomedin 4 0.125345
CCR6 chemokine (C-C motif) receptor 6 0.12445
C3 complement component 3 0.12414
CD1A CD1a molecule 0.123247
CD28 CD28 molecule 0.123154
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.122427
CD14 CD14 molecule 0.122402
ALYREF Aly/REF export factor 0.1218
FASLG Fas ligand (TNF superfamily, member 6) 0.121414
SLAMF1 signaling lymphocytic activation molecule family member 1 0.121098
GLI1 GLI family zinc finger 1 0.120425
HECA headcase homolog (Drosophila) 0.119417
GREM1 gremlin 1, DAN family BMP antagonist 0.117154
CCL25 chemokine (C-C motif) ligand 25 0.116016
GLS2 glutaminase 2 (liver, mitochondrial) 0.11565
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 0.113878
DDR1 discoidin domain receptor tyrosine kinase 1 0.111409
CABIN1 calcineurin binding protein 1 0.110662
RORC RAR-related orphan receptor C 0.110343
LGALS3 lectin, galactoside-binding, soluble, 3 0.10994
CCL4L2 chemokine (C-C motif) ligand 4-like 2 0.109366
ADAM9 ADAM metallopeptidase domain 9 0.108656
CCL4L1 chemokine (C-C motif) ligand 4-like 1 0.108572
CCL24 chemokine (C-C motif) ligand 24 0.108319
CCR3 chemokine (C-C motif) receptor 3 0.107763
ELANE elastase, neutrophil expressed 0.105913
DEFB1 defensin, beta 1 0.105822
CD48 CD48 molecule 0.105228
RGMA repulsive guidance molecule family member a 0.105045
IL16 interleukin 16 0.102828