sarcoma Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A usually aggressive malignant mesenchymal cell tumor most commonly arising from muscle, fat, fibrous tissue, bone, cartilage, and blood vessels. Sarcomas occur in both children and adults. The prognosis depends largely on the degree of differentiation (grade) of the tumor. Representative subtypes are liposarcoma, leiomyosarcoma, osteosarcoma, and chondrosarcoma.|A malignant mesenchymal neoplasm arising exclusively from the soft tissues. Representative examples include soft tissue sarcoma, extraosseous Ewing sarcoma/peripheral primitive neuroectodermal tumor, and malignant hemangiopericytoma.|Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.|A cancer that affects connective tissue resulting in mesoderm proliferation.|A malignant mesenchymal neoplasm arising from muscle tissue, adipose tissue, blood vessels, fibrous tissue, or other supportive tissues excluding the bones.|Type of cancer of the bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. (Experimental Factor Ontology, EFO_0000691)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0100242
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Genes

14 genes associated with the sarcoma phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
EGR2 early growth response 2 1.27072
GRM4 glutamate receptor, metabotropic 4 0.584959
C1ORF127 chromosome 1 open reading frame 127 0.498124
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.443208
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 0.424122
FAM208B family with sequence similarity 208, member B 0.403073
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.396167
CREB5 cAMP responsive element binding protein 5 0.377055
ZC3H3 zinc finger CCCH-type containing 3 0.374594
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.373835
MTSS1 metastasis suppressor 1 0.364711
GPR149 G protein-coupled receptor 149 0.359095
TRAPPC9 trafficking protein particle complex 9 0.34796
RAD50 RAD50 homolog (S. cerevisiae) 0.346149